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Biomedical subjects

Hisashi Ohtsuka

Publications and source records attributed to Hisashi Ohtsuka.

9 recordsLinked to original sources
PubMed2006

Chondrolipoma of the popliteal fossa and Japanese reports.

A rare case of chondrolipoma of the right popliteal fossa in a 24-year-old female was reported with review of the Japanese published work. Eleven patients with chondrolipoma including lipoma with cartilaginous metaplasia, including my case, have been reported in Japan. The patients ranged in age from 7-79 years. All cases occurred in adults except for one. Six patients were male and five were female. Two lesions each arose on the tongue, upper back and popliteal fossa, and one each on the buccal submucosa, shoulder, breast, lateral chest and sole. The duration of the lesions ranged from 1 month to 20 years. The lesions ranged 1-10 cm in greatest dimension. The presented tumor was an early one because of the shortest duration and the smallest size in Japan. Recent criteria for a benign mesenchymoma including a chondrolipoma were also described.

Adult↗
PubMed2005

Synchronous microcystic adnexal carcinoma and gastric cancer with review of the literature.

A microcystic adnexal carcinoma (MAC) on the left lateral chest was synchronously accompanied by both an adenocarcinoma and a granular cell tumor of the stomach in a 70-year-old Japanese male. The MAC lesion had first appeared approximately 20 years earlier and had slowly increased without symptoms. After a definitive diagnosis was made by an excisional biopsy, a second operation was performed with wider excision, followed by split thickness skin grafting. Meanwhile, a punch biopsy from an erosive lesion, which was performed three days before the second operation, demonstrated gastric cancer. Consequently, a gastrectomy was undertaken 20 days later. The patient had since been followed for 2 years and 3 months without any sign of recurrence nor metastasis. Subsequently, soft lymph nodes in two regions of the left axilla were noticed. Three lymph nodes were excised for diagnostic purposes and found to be reactive hyperplasia without metastasis of skin tumor cells. To our knowledge, in the literature, 11 patients have been reported with MAC associated with double or multiple cancers which developed syn- or meta-chronously; ours is the 12th patient.

Aged↗
PubMed2005

Changing trends in the number of deaths from nonmelanoma skin cancer in Japan, 1955-2000.

BACKGROUND: The incidence and number of deaths from nonmelanoma skin cancer (NMSC) have been reported to increase in many countries. However, those in Japan over a long time span have not been analyzed yet. OBJECTIVE: To analyze the changing trends in the numbers of deaths from NMSC in Japan. METHODS: We analyzed the annual trends in numbers of deaths from NMSC from 1955 to 2000 in Japan on the basis of the data from the Vital Statistics of Japan, Statistics and Information Department, Minister's Secretariat, Ministry of Health, Labor and Welfare. RESULTS: The general trends in numbers of deaths from NMSC were downward between 1979 and 1994, but upward after 1995. The recent annual increased proportion of deaths from NMSC was 3.8% (95% confidence interval: 1.3-6.3%). The general trends in age-standardized death rates were roughly downward, although the death rates plateaued after 1995. The number and proportion of deaths among the elderly were increasing. In recent years, more than 50% of the deaths among females occurred at or after 85 years of age, and the corresponding age for males was 75 years or after. CONCLUSION: Elderly individuals should be a focus of health promotion activities.

Age Distribution↗
PubMed2004

Metastatic microcystic adnexal carcinoma: an autopsy case.

BACKGROUND: Microcystic adnexal carcinoma is a clinically aggressive, local destructive sweat gland carcinoma with a high rate of recurrence, but regional or distant metastasis is quite rare. OBJECTIVE: The objective was to describe an autopsy case of microcystic adnexal carcinoma with hematogenous metastasis and perineural intracranial spreads. METHODS: This is an autopsy case of a 73-year-old woman with hematogenous metastasis of microcystic adnexal carcinoma followed for more than 20 years. RESULT: The autopsy study revealed that the metastatic lesions were located in the perineural intracranial spread, left clavicle bone, bilateral 12th ribs, and liver. CONCLUSION: Physicians should be aware that microcystic adnexal carcinoma is capable of metastasis to the liver and bones with intracranial spread along the optic nerve into the cranium.

Adenoma↗
PubMed2003

Nerve conduction and microanatomy in the rabbit sciatic nerve after gradual limb lengthening-distraction neurogenesis.

To clarify how the peripheral nerve adapts to elongation during gradual limb lengthening, electrophysiological and histomorphometric examinations were performed on the sciatic nerves in 18 rabbits. External fixators were used to lengthen the right femora by 30 mm (30%), at a daily rate of 0.5 mm (Group 1) or 2.0 mm (Group 2). Examinations were performed immediately after the limb lengthening procedure. Electrophysiologically, mild conduction slowing was observed in Group 1; a conduction block was evident in Group 2. Histologically, the mean diameter of myelinated fibers was unchanged in Group 1, but a significantly decreased diameter was observed in Group 2. Electron microscopy revealed that mild degenerative change of unmyelinated axons occurred sporadically in two cases in Group 2, but neither group showed evidence of thinning of myelin sheath of myelinated fibers. The mean internodal length (between nodes of Ranvier) of teased fibers was 1216+/-295 microm in the control contralateral side, 1484+/-347 microm in Group 1, and 1467+/-322 microm in Group 2. Thus the internodes were lengthened by 22.1% (Group 1) and 20.7% (Group 2) in comparison with those of the controls. Straightening of the geometry of paranodal myelin sheath was significantly correlated with the rate of distraction. These results indicate that myelinated nerve fibers adapt to gradual elongation by lengthening each Schwann cell body, not by proliferation of Schwann cells.

Adaptation, Physiological↗
PubMed2003

Changing trends in numbers of deaths from malignant melanoma in Japan, 1955-2000.

BACKGROUND: The incidence and number of deaths from cutaneous malignant melanoma have been reported to increase in many countries. However, those in Japan have not been analyzed yet. OBJECTIVE: To analyze the changing trends in the number of deaths from melanoma in Japan. METHODS: We analyzed the annual trends in numbers of deaths from melanoma from 1955 to 2000 in Japan on the basis of the data from the Vital Statistics of Japan, Statistics and Information Department, Minister's Secretariat, Ministry of Health, Labor and Welfare. RESULTS: The general trends in numbers of deaths from melanoma were upward. The annual increased ratio of deaths from melanoma was 6.3% (95% confidence interval: 4.6-8.1%). There was no gender difference in the annual increase in mortality (p < 0.05). The general trends in age-standardized death rates were also upward, although the death rates slowed between 1977 and 2000. The number and proportion of deaths among the elderly were increasing. The peak age group of deaths was roughly the fifties in 1955-1960, the sixties in 1961-1977 and the seventies after 1978. More than 50% of deaths occurred at or after 60 years of age after 1975 in both sexes, increasing to over 70% in 2000. CONCLUSION: Elderly individuals should be a focus of health promotion activities.

Aged↗
PubMed2002

Microcystic adnexal carcinoma: review of 51 Japanese patients.

BACKGROUND: Microcystic adnexal carcinoma (MAC) has been reported to occur predominantly in Caucasians. However, the number of cases in Japanese subjects seems to have recently been increasing. OBJECTIVE: To review the Japanese cases of MAC. METHODS: We collected and analyzed the data of 51 Japanese patients recorded in case reports or abstracts over a number of years. RESULTS: Twenty-five of the cases were reported between 1987 and 1996, and the remaining 26 cases between 1997 and 2000. Forty-three lesions were located on the face, 2 on the scalp, 2 on the chest, 1 on the axilla, 1 on the buttock, 1 on the palm and 1 on the toe. One of the above occurred at the site of previous radiotherapy. Fifteen tumors were initially misdiagnosed histopathologically. CONCLUSION: Our review shows that MAC also occurs in the Japanese, in whom it may be more common than previously observed.

Adult↗
PubMed2002

Multiple eccrine spiradenomas on the hand, forearm and head.

The first case of multifocal eccrine spiradenomas on the hand, forearm and scalp is described. This case is unusual in that the tumors located on the little finger included the nail matrix and occurred in a linear/zosteriform distribution, resulting in a nail deformity. The nodules on the forearm and scalp were in a random distribution. Histologically, each tumor was highly cellular and composed of two cell types: small darkly staining basaloid cells and larger, pale cells. Ultrastructural observations often showed an intracellular lumen with numerous microvilli in larger pale-staining cells.

Adenoma, Sweat Gland↗