[A novel strategy of immno-modulation in sepsis].
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Adjuvants, Immunologic↗
Biomedical subjects
Hong-Yuan Lin
Publications and source records attributed to Hong-Yuan Lin.
[Dynamic change in interleukin-18 and its relationships with multiple organ dysfunction syndrome].
OBJECTIVE: To determine interleukin-18 (IL-18) in plasma after trauma, and evaluate its relationship with multiple organ dysfunction syndromes. METHODS: A total of 54 patients were enrolled and divided into low injury seriousness score (L-ISS) and high injury seriousness score (H-ISS) groups. Blood IL-18 levels were determined on admission, day 4, day 7 and day 14 after trauma using enzyme-linked immunoadsorbent assay (ELISA), and the relationship between its level and organ dysfunction was analyzed. RESULTS: Plasma IL-18 concentration was significantly increased on posttrauma day 4 and day 7. Also, plasma IL-18 concentration was significantly higher in patients with organ dysfunction. CONCLUSION: This study suggests that major trauma can lead to a marked elevation of IL-18, which might be associated with organ dysfunction.
Adult↗
[Current understanding in definitions and diagnosis of sepsis].
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China↗
[Sepsis: challenge and intervention strategy].
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Humans↗