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Hongrui Zhang

Publications and source records attributed to Hongrui Zhang.

2 recordsLinked to original sources
PubMed2026

Identification of the R2R3-MYB gene family in wild jujube (Ziziphus jujuba var. spinosa) and analysis of its expression under drought stress.

BACKGROUND: R2R3-MYB gene family serves as a pivotal regulatory factor in plant growth, development, and responses to environmental stresses. To investigate its function in the drought stress response of wild jujube (Ziziphus jujuba Mill. var. spinosa), a typical eco-economic forest species, this study performed genome-wide identification and relevant analyses of R2R3-MYB genes. RESULTS: A total of 91 R2R3-MYB genes (designated as ZjMYB1 to ZjMYB91) were identified, which were unevenly distributed across 12 chromosomes. These genes mainly encode hydrophilic and unstable proteins, 97.8% of which are localized in the nucleus. Phylogenetic analysis classified these genes into 25 clades, showing evolutionary conservation and species-specific divergence with the R2R3-MYB protein family. The expansion of the ZjMYB family is mainly characterized by segmental duplication, and all duplicated gene pairs have undergone purifying selection. ZjMYBs are widely involved in plant growth and development as well as abiotic stress responses, with the highest expression level particularly in leaf tissues; a total of 13 genes were specifically annotated as water deficit response-related genes in drought stress and abscisic acid (ABA) signaling pathways. Integrating the above analyses together with transcriptome data and qRT-PCR validation results revealed that ZjMYB5, ZjMYB53, ZjMYB57 and ZjMYB85 function as core drought-responsive genes, which display both tissue-specific and time-dependent expression patterns under drought stress. CONCLUSIONS: This study systematically elucidated the functional characteristics and regulatory network of the R2R3-MYB gene family in wild jujube, providing critical genetic resources and a theoretical basis for dissecting the molecular mechanisms underlying drought tolerance in wild jujube and breeding drought-resistant cultivars.

Ziziphus↗
PubMed2026

Tranexamic acid in spontaneous intracerebral hemorrhage: an updated systematic review and meta-analysis of randomized controlled trials.

BACKGROUND: Tranexamic acid (TXA) is a well-established antifibrinolytic medication in the general population. However, its efficacy and safety for patients with spontaneous intracerebral hemorrhage (ICH) remain inconclusive. Consequently, we conducted a systematic review and meta-analysis to assess the effectiveness and safety of TXA for spontaneous ICH. METHODS: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) following established methodological standards. Our search encompassed eight electronic databases from inception to April 25, 2024. The primary outcome was a reduction in all-cause mortality. The secondary outcomes included improvements in functional independence, neurological impairment, activities of daily living, and reduction in hematoma expansion (HE). Fixed-effects or random-effects model were performed for pooled data where eligible. RESULTS: A total of 9 RCTs that initially enrolled 3,124 patients were included. There were no significant differences observed concerning all-cause mortality (RR, 1.03; 95% CI [0.89-1.18]), hematoma expansion (RR, 0.90; 95% CI [0.80-1.00]), improvement of functional independence (RR, 1.02; 95% CI [0.92-1.12], neurological impairment (MD, -0.88 [95% CI, -2.22-0.45]), or activities in daily living (MD, -0.83 [95% CI, -29.25-12.59]). The pooled data indicated that TXA for ICH was associated with a decrease in hematoma volume from baseline (MD, -1.74; 95% CI [-2.47 to -1.02]). No significant difference in adverse events was observed between the TXA group and the control group. CONCLUSIONS: In summary, TXA does not affect all-cause mortality, functional outcomes, or neurological impairment, nor does it reduce HE, despite reducing hematoma volulume. TXA use for ICH requires careful clinical consideration.

Humans↗