Biomedical subjects

Hongwei Shen

Publications and source records attributed to Hongwei Shen.

3 recordsLinked to original sources

PubMed2006

A practical scoring system based upon ROC analysis for evaluating potential lymph nodes metastasis during gastric surgery.

BACKGROUND AND OBJECTIVES: Current preoperative N staging does not offer an accurate estimation of lymph node involvement. We establish a new scoring system for predicting N stages to guide a rational lymphadenectomy for gastric cancer. METHODS: Variables correlated with N stages were selected by multivariate stepwise logistic regression analysis. Variables granted the different scores according to the odds ratio (OR). Receiver operating characteristic (ROC) analysis was used to generate scoring ranges from N0 to N3. The agreement between predicted N staging and actual pN classification was analyzed using kappa statistics. RESULTS: Tumor size, depth of invasion, and histological types were selected to establish the scoring system. Scores 0-4, 5-7, 8-9, and 10-13 were postulated to predict N0-3, respectively. The predicted N stage has good agreement with the actual pN classifications. The negative predictive values for N0-3 were 87.0, 86.4, 90.4, and 90.2%; the positive predictive values were 74.7, 62.8, 57.3, and 69.6%, respectively. The accuracy is 82% for N0-1, and 83.7% for N2-3. CONCLUSIONS: The new scoring system can predict the N stage of gastric cancer. With its good negative predictive value, it is possible to minimize the potential hazards of applying a more extensive lymph node dissection than necessary.

Adult↗

PubMed2003

Expression and role of adrenomedullin and its receptor in patients with chronic obstructive pulmonary disease.

OBJECTIVE: To investigate the expression and role of adrenomedullin (ADM) and adrenomedullin receptor (ADMR) in patients with chronic obstructive pulmonary disease (COPD). METHODS: Small pulmonary artery remodeling was observed using morphometric analysis. The expression of ADM and ADMR mRNA in lung tissue was calculated by in situ hybridization in 9 COPD cases. Cardiac catheterization was performed in 22 COPD cases to monitor changes of hemodynamic parameters and patients were divided into two groups based on mean pulmonary artery pressure (mPAP). The cases without pulmonary hypertension (PH) were placed in Group A (n = 12) and those with PH were placed in Group B (n = 10). The levels of pulmonary arterial plasma ADM were measured by radioimmunoassay. Blood gas analysis was also conducted. RESULTS: The ratio of vascular wall thickness to external diameter (MT%) and the ratio of vascular wall area to total area (MA%) were higher in patients with COPD (P < 0.01). In situ hybridization showed that ADM mRNA and ADMR mRNA were expressed in the pulmonary artery walls of control subjects. The expression levels were significantly higher in those of COPD sufferers (P < 0.01). Statistically positive relationships were visible between ADM and ADMR, and the plasma ADM level of Group B was significantly higher than that of Group A (P < 0.05). The plasma ADM level had a significantly positive correlation to mPAP and pulmonary vascular resistance (PVR), while being negatively correlated to levels of PaO(2). CONCLUSION: ADM may play an extremely protective role as a local autocrine/paracrine factor in COPD.

Adrenomedullin↗

PubMed2002

[Binding pancreaticojejunostomy: clinical report of 150 cases].

OBJECTIVE: To study the safety and feasibility of a new operative procedure called binding pancreaticojejunostomy (BPJ) used to prevent anastomotic leakage following pancreatoduodenectomy (PD). METHODS: From 1996 to 2001, a newly developed operative procedure, binding pancreaticojejunostomy, was performed upon 150 cases undergoing PD. The remnant of pancreas was sutured with and invaginated into the jejunum, with the suture needle only penetrating the mucosa and not the seromuscular layer. The mucosa of jejunum near the pancreatic remnant was destroyed by electric coagulation or phenol. The pancreas and jejunum were bound together so that they were pressed close to each other. The clinical data were reviewed and analysed. RESULTS: The operation of BPJ was performed smoothly on all 150 patients. No pancreatic leakage occurred. CONCLUSION: The BPJ procedure is effective in avoiding anastomotic leakage following PD.

Adult↗