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Biomedical subjects

Hongwei Xu

Publications and source records attributed to Hongwei Xu.

6 recordsLinked to original sources
PubMed2003

[The relationship of apolipoprotein H G1025C (Try316Ser) polymorphism with stroke and its effect on plasma lipid levels in Changsha Hans].

OBJECTIVE: To investigate the relationship between G1025C (Try316Ser) polymorphism in exon 8 of apolipoprotein H (apoH) gene and stroke and to evaluate the effect of G1025C(Try316Ser) polymorphism on plasma lipid levels in Changsha Hans. METHODS: G1025C (Try316Ser) polymorphism in apoH gene was determined by PCR-single strand conformation polymorphism analysis and DNA sequencing in 100 healthy controls, 260 patients with stroke, and 20 stroke pedigrees. Serum antiphospholipid antibody (APA) levels were tested by enzyme linked immunosorbent assay (ELISA). Plasma lipid levels were measured by routine methods. RESULTS: No statistically significant differences were found in frequencies of genotypes and alleles of G1025C (Try316Ser) polymorphism between the controls and stroke patients. The serum levels of TG in the GC genotype of cerebral infarction patients and controls were markedly higher than those in GG genotype. CONCLUSION: There was no association betweenG1025C (Try316Ser) polymorphism and stroke in Changsha Hans. G1025C (Try316Ser) polymorphism was associated with plasma lipid metabolism in Changsha Hans.

Adult↗
PubMed2002

Parallel analysis with optically gated sample introduction on a multichannel microchip.

As an alternative to the T-type injection on microchips, optically gated sample introduction previously has been demonstrated to provide fast, serial, and reproducible injections on a single-channel microchip. Here, the ability to perform high throughput, multichannel analysis with optically gated sample introduction is described using a voice coil actuator. The microchip is fixed on a stage, which moves back and forth via the voice coil actuator, scanning two laser beams across the channels on the microchip. For parallel analysis on a multichannel microchip, both the gating beam and the probe beam are scanned at 10 Hz to perform multiple injections and parallel detection. Simultaneous, fast separations of 4-choloro-7-nitrobenzofurazan (NBD)-labeled amino acids are demonstrated in multiple channels on a microchip. Serial separations of different samples in multiple channels are also reported. Optically gated sample introduction on multiple, parallel channels shows the potential for high-speed, high-throughput separations that are easily automated by using a single electronic shutter.

4-Chloro-7-nitrobenzofurazan↗
PubMed2002

[Relationship between apolipoprotein H and lipid in stroke patients].

OBJECTIVE: To study the correlation of serum apolipoprotein H (ApoH) with blood lipids and the relationship between ApoH and stroke. METHODS: The serum levels of ApoH of 33 patients with acute cerebral infarction (ACI), 18 patients with acute cerebral hemorrhage (ACH), 17 patients with cerebral apoplexy and family history, and 33 healthy control were measured by radioimmunoassay. The blood lipids of the above mentioned subjects were measured by enzymological methods. RESULTS: The serum ApoH levels in acute cerebral infarction (ACI) patients, acute cerebral hemorrhage (ACH) patients, and healthy controls were 288 +/- 85 mg/L, 248 +/- 68 mg/L, and 256 +/- 71 mg/L respectively. There was a significant correlation between serum ApoH and total CHO and between ApoH and LDL in ACI patients (r = 0.394, P < 0.05; r = 0.394, P < 0.05). However, no correlation between ApoH and triglyceride was found. In 17 cases of cerebral apoplexy with familial history, the serum ApoH was correlated with HDL. CONCLUSION: Serum ApoH is correlated with CHO and LDL in ACI patients. No such correlation can be found in healthy persons and ACH patients.

Aged↗
PubMed2002

[Distribution characteristics of types of stroke in three urban area in China].

OBJECTIVE: To analyze the distribution characteristics of types of stroke in china. METHODS: A prospective study and comprehensive prevention were conducted in urban communities with 300 000 people in Changsha, Beijing and Shanghai, and 2 570 case of stroke at their first occurance were selected with established typing diagnosis (r). RESULTS: Hemmorrhagic, ischemic, and unclassified stroke accounted for 37.1%, 62.3%, and 0.6% respectively. The proportion of hemmorrhagic stroke was more than 50 percent among persons under 50. The average yearly incidence of stroke was 142.3/100 thousand in the intervention areas and was 187.0/100 thousand in the control areas. CONCLUSION: Prevention should be focused on hemorrhagic stroke for those aged over 50 and on ischemic stroke for those aged less than 50. The average incidence rates of hemmorrhagic and of ischemic stroke were lower in the intervention area than in the control area.

Adolescent↗