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Howard Minkoff

Publications and source records attributed to Howard Minkoff.

65 records · Page 4Linked to original sources
PubMed2002

Prevalence and predictors of Toxoplasma seropositivity in women with and at risk for human immunodeficiency virus infection.

We assessed the prevalence and predictors of latent Toxoplasma infection in a large group of human immunodeficiency virus (HIV)-infected and HIV-uninfected at-risk US women. The prevalence of latent Toxoplasma infection was 15% (380 of 2525 persons) and did not differ by HIV infection status. HIV-infected women aged > or =50 years and those born outside of the United States were more likely to have latent Toxoplasma infection, with prevalences of 32% and 41%, respectively.

AIDS-Related Opportunistic Infections↗
PubMed2002

Causes of death among women with human immunodeficiency virus infection in the era of combination antiretroviral therapy.

PURPOSE: To examine changes in the causes of death and mortality in women with human immunodeficiency virus (HIV) infection in the era of combination antiretroviral therapy. METHODS: Among women with, or at risk of, HIV infection, who were enrolled in a national study from 1994 to 1995, we used an algorithm that classified cause of death as due to acquired immunodeficiency syndrome (AIDS) or non-AIDS causes based on data from death certificates and the CD4 count. Poisson regression models were used to estimate death rates and to determine the risk factors for AIDS and non-AIDS deaths. RESULTS: Of 2059 HIV-infected women and 569 who were at risk of HIV infection, 468 (18%) had died by April 2000 (451 HIV-infected and 17 not infected). Causes of death were available for 428 participants (414 HIV-infected and 14 not infected). Among HIV-infected women, deaths were classified as AIDS (n = 294), non-AIDS (n = 91), or indeterminate (n = 29). The non-AIDS causes included liver failure (n = 19), drug overdose (n = 16), non-AIDS malignancies (n = 12), cardiac disease (n = 10), and murder, suicide, or accident (n = 10). All-cause mortality declined an average of 26% per year (P = 0.03) and AIDS-related mortality declined by 39% per year (P = 0.01), whereas non-AIDS-related mortality remained stable (10% average annual decrease, P = 0.73). Factors that were independently associated with non-AIDS-related mortality included depression, history of injection drug use with hepatitis C infection, cigarette smoking, and age. CONCLUSION: A substantial minority (20%) of deaths among women with HIV was due to causes other than AIDS. Our data suggest that to decrease mortality further among HIV-infected women, attention must be paid to treatable conditions, such as hepatitis C, depression, and drug and tobacco use.

Acquired Immunodeficiency Syndrome↗
PubMed2002

Prevalence and correlates of highly active antiretroviral therapy switching in the Women's Interagency HIV Study.

OBJECTIVE: The purpose of this study was to describe the variability in highly active antiretroviral therapy (HAART) regimens over time, the extent to which individuals switch, and the characteristics of those who are switching. METHODS: We evaluated data collected between 1994 and 2000 from 1056 HIV-positive women enrolled in the Women's Interagency HIV Study (WIHS) who reported initiating HAART. We described the variability and prevalence of changes in HAART regimens between semiannual visits, estimated time to switch using Kaplan-Meier methods, investigated factors associated with a first switch using Cox proportional hazards models, and compared disease markers among women switching or remaining on unchanged HAART regimens. RESULTS: We demonstrated a 13-fold increase in the number of unique HAART regimens reported since mid-1996 and showed that the amount of time spent on the first, second, or third regimen is similar, with an 8-month median time to switching or discontinuing the initial HAART regimen. Women who switched had a lower mean CD4 cell count and were more likely to have HIV RNA levels greater than 400 copies/mL. Overall, the percentage of women switching decreased over the course of follow-up (to 37% in September 2000), although the percentage discontinuing therapy altogether increased 2-fold. CONCLUSION: Our findings on the relatively high rate of HAART switching emphasize the complexity of managing and evaluating these therapies.

Adolescent↗
PubMed2002

Lymphoid follicles are generated in high-grade cervical dysplasia and have differing characteristics depending on HIV status.

The exact role of the mucosal immune response in the pathogenesis of human papillomavirus (HPV)-related premalignant and malignant diseases of the genital tract is poorly understood. We used immunohistochemical analysis to characterize immune cells in normal cervix (N = 21), HIV-negative high-grade dysplasia (N = 21), and HIV-positive high-grade dysplasia (N = 30). Classical germinal centers were present in 4.7% of normal cervix, 33% of high-grade lesions from HIV-negative women, and 3.3% of high-grade lesions from HIV-positive women (P = 0.003). HPV16 E7 antigen was detected in a subset of germinal centers, indicating that the secondary immune response was directed in part against HPV. Lymphoid follicles were present in 9.5% of normal cervix, 57% of HIV-negative high-grade dysplasia, and 50% of HIV-positive high-grade dysplasia (P = 0.001 normal versus high-grade). A novel type of lymphoid aggregate, consisting predominantly of CD8(+) T cells, was detected in 4.8% of normal cervix, 0% of HIV-negative high-grade dysplasia, and 40% of HIV-positive high-grade dysplasia (P < 0.001). The recurrence rate of high-grade dysplasia within one year was significantly higher in women with such CD8(+) T cell-dominant aggregates (P = 0.02). In summary, the types of lymphoid follicle in lesions from HIV-positive women were significantly different from those from HIV-negative women, and these differences are associated with the worse clinical outcome in HIV-positive women.

Adult↗
PubMed2002

Changes in cervical length and the risk of preterm labor.

OBJECTIVE: The purpose of this study was to assess the value of cervical length change as a predictor of preterm labor. STUDY DESIGN: We used an historic cohort of 154 women to compare change in cervical length and preterm birth. Independent variables included cervical length at the first sonogram, absolute change of cervical length, and change per unit time. Covariates included age, parity, and history of preterm birth. Eligible patients had 2 or more sonograms that included cervical length. RESULTS: The risk of preterm delivery increased as the length of the cervix declined, after an adjustment was made for the initial cervical length (P <.05). There were no significant interactions between initial length and the change of length; however, the highest rate of preterm deliveries occurred among women with a cervical length <3 cm at the first sonogram (23%). If the change in cervical length was expressed as a unit equal to a decline of 1 cm per month, the odds of giving birth to a preterm baby were 6.8-fold greater per unit change (P <.05). CONCLUSION: A cervical length of <3 cm before 16 weeks of gestation is associated strongly with preterm birth; independently of baseline length, more rapid shortening of the cervix increases the risk of preterm birth.

Cervix Uteri↗
PubMed2002

Determinants of women's choice of obstetrician/gynecologist.

INTRODUCTION: There has been a reported increase in women's desires to have female medical providers. It is unclear if this finding extends to obstetrician/gynecologists or how important gender is relative to other factors in choosing a provider. This study seeks to address these issues. METHODS AND MATERIALS: In community locations in Brooklyn, New York, 537 women completed a questionnaire regarding demographics, gender of their current provider, and whether they considered age, gender, experience, location, or cost to be the most important factor in choosing an obstetrician/gynecologist. They rated their current experience and the importance of gender using a 10-point Likert scale. RESULTS: Overall, 61% of participants preferred a female provider. The proportion did not vary with gender of the interviewer or participants' age. A female provider was preferred by 56% of Protestants, 58% of Catholics, and 58% of Jews and by 74% of Hindus and 89% of Muslims (p = 0.02). Regardless of whether a woman preferred a male or a female provider, 38% of participants felt strongly (7-10 on Likert scale) that gender was important. There was no difference in satisfaction with current provider between women who preferred a male or female provider. Gender was as important in choosing an obstetrician as experience or cost. Almost as many women with a female provider indicated a preference for a male (46%) as women with a male provider who preferred a female provider (54%). CONCLUSIONS: A slight majority of these women, particularly those who are Hindu or Moslem or currently use a female, prefer female providers. Only a minority of these women feel strongly about their preference, and women with male providers are as satisfied as are women with female providers. Gender of provider was about as important as a physician's experience in choice of clinician.

Adult↗
PubMed2002

The impact of HIV infection and immunodeficiency on human papillomavirus type 6 or 11 infection and on genital warts.

BACKGROUND: HIV infection and associated immunodeficiency are known to alter the course of human papillomavirus (HPV) infections and of associated diseases. GOAL: This study investigated the association between HIV and HPV and genital warts. STUDY DESIGN: HPV testing and physical examinations were performed in two large prospective studies: the Women's Interagency HIV Study (WIHS) and the HIV Epidemiology Research Study (HERS). Statistical methods incorporating dependencies of longitudinal data were used to examine the relationship between HIV and HPV and genital warts. RESULTS: A total of 1008 HIV-seronegative and 2930 HIV-seropositive women were enrolled in the two studies. The prevalence of HPV 6 or 11 was 5.6 times higher in HIV-seropositive women in the WIHS and 3.6 times higher in the HERS. Genital wart prevalence increased by a factor of 3.2 in the WIHS and 2.7 in the HERS in HIV-seropositive women. In the WIHS, infection with HPV type 6 or 11, in comparison with no HPV infection, was associated with odds of genital wart prevalence of 5.1 (95% CI: 2.9-8.8), 8.8 (95% CI: 6.1-12.8), and 12.8 (95% CI: 8.8-18.8) in HIV-seronegative women, HIV-seropositive women with > or =201 CD4 cells/microl, and HIV-seropositive women with < or =200 CD4 cells/microl, respectively. In the HERS, infection with HPV type 6 or 11 was associated with odds of 2.7 (95% CI: 1.6-4.6), 4.9 (95% CI: 3.2-7.7), and 5.3 (95% CI: 3.3-8.5) in these same groups. Other HPV types showed a similar dose-response relation, but of substantially lower magnitude and statistical significance. CONCLUSIONS: HIV infection and immunodeficiency synergistically modified the relation between HPV 6 or 11 infection and genital wart prevalence.

AIDS-Related Opportunistic Infections↗
PubMed2002

Maternal mortality in America: lessons from the developing world.

In separate but related articles, Drs. Tsu and Goodburn outline strategies for confronting the staggering number of maternal deaths in the developing world: monitoring process indicators and elucidating technologically feasible interventions. American providers face a maternal mortality rate that is only a fraction of that seen in the developing world, but they are challenged by large disparities in perinatal outcomes between African Americans and whites. Strategies similar to those advanced by Tsu and Goodburn might be applicable in the United States. American perinatal health care providers need to look beyond the details of individual adverse events to the structure of care in settings where adverse outcomes are common. Inadequate staffing levels, overcrowded neonatal intensive care units, and provider fatigue are examples of structural problems that have been linked to poor outcomes. Ultimately, improved quality may be achieved only after the relationship between poor-quality health care (medical errors) and inequality is recognized and acted on. Providers should take an active role in identifying and reporting near misses and in developing the skills and technologies with which to implement systems that prevent recurrences.

Black or African American↗