Biomedical subjects

Huban Atilla

Publications and source records attributed to Huban Atilla.

6 recordsLinked to original sources

PubMed2006

Pattern electroretinography and visual evoked potentials in optic nerve diseases.

BACKGROUND: To evaluate transient pattern electroretinography (PERG) and pattern visual evoked potential (VEP) for the diagnosis, differential diagnosis and follow-up of optic nerve diseases. METHODS: Twenty-nine consecutive patients (14 female, 15 male) with the diagnosis of ischaemic optic neuropathy (n=14) and optic neuritis (n=15) were included in this study. Mean age of the patients with ischaemic optic neuropathy was 63.3+/-3.3 (60-78) years and the mean age of the patients with optic neuritis was 28.3+/-8.4 (19-43) years. In each patient ophthalmological examination and systemic evaluation were done and VEP and PERG were recorded. As a control group, VEP recordings of 35 healthy subjects were included. RESULTS: In the ischaemic optic neuropathy group (group 1), mean VEP amplitude (+/-SD) (1.96+/-0.95 microV) was found to be decreased significantly in the affected eyes in comparison to the control group and the unaffected eyes. The delay in latency (116.3+/-20.14 msec in the affected eyes compared with 101.31+/-6.19 msec in unaffected eyes) was statistically significant when compared with the healthy subjects. In the optic neuritis group (group 2), VEP amplitude was decreased (4.13+/-4.04 microV vs 6.97+/-3.35 microV and 6.97+/-4.43 microV) and latency was increased (122.59+/-20.09 msec vs 101.31+/-6.19 msec and 108.76+/-13.57 msec) in affected eyes significantly in comparison to the unaffected eyes and control group, respectively. Even though there were no significant differences for P50 latency and N95/P50 ratios between affected and unaffected eyes in both groups, N95 amplitude decreased significantly in the affected eyes of the ischaemic optic neuropathy patients and N95 latency was found to be decreased in optic neuritis patients. There was no correlation between VEP and PERG findings in both groups. CONCLUSION: VEP amplitude decreased significantly in ischaemic optic neuropathies while latency delay was more significant in patients with optic neuritis. PERG findings showed decreased N95 amplitude in ischemic optic neuropathy without associated latency changes.

Adult↗

PubMed2005

Retinal nerve fiber analysis in subjects with hyperopia and anisometropic amblyopia.

PURPOSE: To determine the changes in retinal nerve fiber layer thickness in subjects with high hyperopia and anisometropic amblyopia. METHODS: Retinal nerve fiber layer thickness was measured with scanning laser polarimetry and confocal scanning laser tomography in subjects with hyperopia (n=18) with a mean age of 16.6 +/-3.1 years and anisometropic amblyopia (n=14) with a mean age of 17.4 +/-3.8 years. A control group consisted of 25 healthy emmetropic subjects with a mean age of 25.7 +/-11.8 years. In all subjects 3 measurements with 2 different techniques were obtained and the average values for each parameter were analyzed and compared between the groups. RESULTS: Heidelberg Retinal Tomography revealed a smaller disc area and cup/disc ratio (C/D) in the hyperopic and amblyopic subjects in comparison to the control group, however there was no statistically significant difference between the hyperopia and amblyopia groups. Increased nerve fiber layer thickness in these groups had no statistical significance. There was also no statistically significant difference in various parameters in the measurements taken with scanning laser polarimetry. CONCLUSION: Refractive errors may change the quantitative assessment of optic nerve head topography and retinal nerve fiber layer thickness. There is no associated nerve fiber layer changes in anisometropic amblyopic subjects in comparison to the control group and the subjects with high hyperopia.

Adolescent↗

PubMed2004

Best's vitelliform macular dystrophy with pseudohypopyon: an optical coherence tomography study.

PURPOSE: To report optical coherence tomography (OCT) changes in Best's vitelliform macular dystrophy (BVMD) with pseudohypopyon. DESIGN: Observational case report. METHODS: Both eyes of a patient with BVMD showing pseudohypopyon were examined with OCT. RESULTS: OCT demonstrated the presence of serous retinal elevation with normal appearing retinal pigment epithelium (RPE) superiorly, and broadening of the outer-retina-choroid-complex signal under retinal elevation, inferiorly. CONCLUSIONS: OCT findings in our study suggest the accumulation of material under neurosensory retina in BVMD with pseudohypopyon.

Electrooculography↗

PubMed2003

Effects of intracameral lidocaine on ocular tissues.

PURPOSE: To investigate the ultrastructural changes in iris and corneal tissue induced by intracameral 1% lidocaine infusion applied during lens extraction in a rabbit model. METHODS: The study was conducted using New Zealand rabbits. Eight rabbits received 0.2 mL 1% lidocaine hydrochloride intracamerally and lens extraction was performed, keeping the posterior capsule intact. After lens extraction, cornea and iris tissue samples were obtained for electron microscopy. Eight eyes were included as a control group. RESULTS: Electron microscopy revealed morphological abnor-malities in both cornea and iris of the lidocaine injected eyes, different from the control group. Cytoplasmic vacuolization, phagosomes and residual bodies were observed in epithelial cells. Corneal fibroblasts contained fluid-filled vacuoles, which could be due to the influx of water into the cells as a result of corneal endothelial damage. Mitochondrial swelling and residual bodies were also seen in the cytoplasm of fibroblasts. Blood vessels in the iris contained fluid material composed of fibrin and proteinaceous material and many vacuoles showed vascular endothelial injury. CONCLUSION: Even a short period of exposure of intra-cameral lidocaine to the ocular tissues can induce histo-logical changes that may result in functional defects.

Anesthetics, Local↗

PubMed2003

Chiasmal high signal on magnetic resonance imaging in the atrophic phase of leber hereditary optic neuropathy.

A 30-year-old man with Leber hereditary optic neuropathy mutation 11778 displayed no magnetic resonance imaging abnormalities during the acute phase of visual loss in the right eye. Three months later, during the acute phase of visual loss in the left eye, magnetic resonance imaging showed T2 hyperintense signal changes on the right half of the optic chiasm. Six months later, magnetic resonance imaging revealed T2 hyperintense signal changes on both sides of the optic chiasm. This is the first reported case of optic chiasmal involvement on magnetic resonance imaging in the atrophic phase of Leber hereditary optic neuropathy.

Adult↗

PubMed2002

Pediatric alacrima, achalasia, and mental retardation.

Absence or deficiency of tear volume (alacrima) is rarely seen in pediatric ophthalmology. It is often a part of the multiple systemic anomalies like Riley-Day syndrome and anhidrotic ectodermal dysplasia, or it may be associated with adrenal gland insufficiency, achalasia, and neurologic disorders like Allgrove's syndrome. We report on a 7-year-old girl presenting alacrima, achalasia, and mental retardation with normal adrenocortical function.

Child↗