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Biomedical subjects

I A Chekmareva

Publications and source records attributed to I A Chekmareva.

12 recordsLinked to original sources
PubMed2006

Morphological changes in the implantation zone of Prolen and Esfil reticular endoprostheses.

Comparative histological and electron microscopic study of tissues in the zone of implantation of polypropylene endoprostheses Prolen and Esfil was carried out in mice. Implantation of a reticular endoprosthesis Esfil was associated with a more pronounced infiltration with neutrophilic granulocytes, macrophages, and lymphocytes. Both nets were characterized by pronounced integration in the adjacent tissues in the implantation zone and can be recommended for clinical use.

Animals↗
PubMed2004

[Development of new biologically active dressings and methodology of their use].

Results of development of new biologically active dressings and up-to-date methodology of local treatment of wounds (based on their differential application according to phase and features of wound process) are demonstrated. Data about main properties and specific activity of new biologically active dressings based on natural and synthetic polymers with immobilized drugs are presented. Future trends and efficacy of their appliance in complex treatment of purulent and necrotic wounds are demonstrated.

Acrylates↗
PubMed2002

Experimental study of reparative regeneration processes in the wound treated with bioactive dressings.

Quantitative and structural functional analysis of granulation tissue cells during treatment with protein-polysaccharide dressing Collahit F was carried out. The preparation effectively cleansed the wound from detritus, prevented secondary infection due to stimulation of the functional activity of macrophages and due to the effect of its antiseptic component (furagin), and stimulated proliferative activity of fibroblasts and granulation tissue microvessels on day 5 of treatment, thus promoting repair processes in the wound.

Animals↗
PubMed2000

Specific effect of epidermal growth factor immobilized on wound coating with soluble collagen on healing of experimental wounds.

Electron-microscopy and autoradiography of granulation tissue in wounds showed that bioactive coating with epidermal growth factor activates functional and proliferative processes in vascular cells (endotheliocytes and pericytes) and fibroblasts and increases the number of cell-to-cell contacts on days 2-3 of therapy. Pronounced activation of proliferative processes resulted in early differentiation of fibroblast cells (on days 3-4) and rapid epithelialization of the wound.

Animals↗
PubMed1993

[Electron-autoradiographic study of burn wound healing while treated with levosin ointment].

Electron-microscopic radioautography was employed to study the crust and granulation tissue from patients with thermal burn injuries degree II-IV, before treatment, 10 and 20 days after application of levosin ointment. Local introduction of the ointment promoted the burn healing as shown by an increase in the number of fibroblasts and vessels of the granulation tissue, by activation of fibroblast function and proliferation, by destruction of bacteria and reduction in their number.

Anti-Bacterial Agents↗
PubMedDate not supplied

[The tissue survival problem in using current methods of morphological study].

Time course of ultrastructural changes and RNA production in human brain and myocardial cells during the period between clinical and biological death is studied. Changes in the cytoplasm of brain neurons develop 4 hours after death, and 8 h post mortem the destructive changes in the cytoplasm and nuclei progress. During the period of 4-13 h post mortem the endotheliocyte nuclei are capable of producing RNA. Active production of RNA is on-going in the myocyte nuclei 4 h after death; the synthetic activity decreases by 8 h and by 13 h the synthetic activity in autopsy material is over.

Adolescent↗
PubMedDate not supplied

[The survivability time of central nervous system cells].

Our investigations show that vital functions of some neurons and glial cells may survive for 4-8 hours after death and disappear in parallel with destructive changes in cells. Up-to-date morphological techniques demonstrate that neurons and other cells of the CNS preserve biological activity not for several minutes as believed so far but up to 4-8 hours. It is too early to judge about functional importance of this phenomenon and further investigations into this problem are necessary. Temporal parameters of RNA synthesis in the brain cells give additional knowledge about CNS cells survival and this may be of interest for reanimatology and transplantology.

Autopsy↗
PubMedDate not supplied

[Pathological basis for clinical stages of the proliferative process in diabetic retinopathy].

In order to elucidate the relationships between posterior ocular structures, 48 samples of epiretinal membranes were examined, which were obtained during transcilliary vitrectomy for proliferative diabetic retinopathy of different stages (29 patients with type I diabetes mellitus and 19 with type 2). The findings of morphological analysis and preoperative ophthalmoscopy (color photographs) demonstrated clinical and morphological correlations of stages of proliferative diabetic retinopathy. Impossibility of differential diagnosis between posterohyaloid membrane and newly formed tissue by clinical methods and impossibility of their mechanical intraoperative separation allow us to regard the stages of proliferative process as stages in changes of the posterohyaloid membrane proper. The posterohyaloid membrane is detected clinically and morphologically only in the presence of pathological changes, including diabetic retinopathy. We detected the following clinical histological correlations of proliferative process stages in diabetic retinopathy: 1) glial; 2) glio-vascular; 3) glio-vascular-fibrous; 4) fibrovascular; 5) fibrous (cicatricial). The histology of stages of proliferative diabetic retinopathy and correlation of histological findings with the clinical (ophthalmoscopic) picture of the process are described in detail. Recommendations on the treatment of each of these stages are offered.

Adolescent↗
PubMedDate not supplied

[Effect of serotonin-adipinate on the ultrastructure and synthetic activity of endotheliocytes of microhemocirculatory bed of human brain (autopsy material, early autopsies)].

Electron-microscopic and radioautographic investigation showed the ability of brain capillary endotheliocytes for retaining functional activity in total ishemia. Administration of serotonin adipinate in an early postoperative period supports intracellular processes and plays a protective role.

Adipates↗
PubMedDate not supplied

[Electron-radioautographic study of differential influence of biologically active wound covering on the process of regeneration].

It is established that local wound treatment with coverings is directed to both suppression of microflora and inflammatory process and stimulation of regeneration at early periods of wound healing, this favouring granulation tissues growth and wound epithelization. Mechanism of biologically active covering influence on the reparative regeneration lies in stimulation of fibroblast, endotheliocyte and pericyte proliferation and stimulation of granulation tissue cells functional activity.

Animals↗
PubMedDate not supplied

[The specificity of the ultrastructural pattern of neoplastic vessels of the retina in diabetic retinopathy].

The electron microscopy of 14 samples of epiretinal membranes obtained in the course of transciliary vitrectomy performed in proliferative diabetic retinopathy (PDR) showed a majority of neovascularized vessels to be represented by those of the venular type or capillaries. It can be concluded on the basis of examination results that the structures of neovascularized vessels can be highly diverse in diabetic retinopathy, which depends on a variety of factors: 1) proliferation stage; 2) division of the microcirculation bed; and 3) end of the epiretinal membrane where a given vessel is located as to the growth epicenter. Finally, described are both neo-vessels with a virtually normal structure of the vascular wall and atrophying vessels. The signs of vascular reduction grow to be more pronounced at later stages.

Diabetic Retinopathy↗