Biomedical subjects
Publications and source records attributed to I A Dukes.
The concomitant occurrence of pregnancy and chronic myeloid leukemia is uncommon. The use of hydroxyurea in chronic myeloid leukemia during pregnancy is unknown. We report on a patient with chronic myeloid leukemia in whom hydroxyurea was used during pregnancy with a successful outcome for both mother and fetus.
Protein C is a vitamin K-dependent anticoagulant that functions by inhibiting the activity of factors Va and VIIIa. An inherited deficiency of this protein may enhance the risk of thrombosis. The first kindred with levels of protein C that averaged 50% of normal in association with recurrent thrombotic events were described in 1981. A black South African family with an inherited deficiency of this protein is reported.
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Among the rare acute mixed-lineage leukaemias, a myeloid T-cell phenotype has recently been recognised. An additional case characterised by myeloid cytochemistry, development of Auer rods in culture and Tdt, WT1 and T11 phenotypes on cell-marker analysis is reported. The patient died from disseminated non-reactive tuberculosis after chemotherapy.