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Biomedical subjects

I A Egorov

Publications and source records attributed to I A Egorov.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

[Formation of alcohols during sucrose heating with amino acids].

The formation of alcohols during sucrose heating with amino acids was investigated. The sucrose heating to 180-190 degrees C resulted in the formation of methanol and ethanol and its heating with alanine--propanol and isobutanol. The sucrose heating with phenylalanine led to the formation of beta-phenylethanol as well. Alcohols were identified as benzoates by paper chromatography. They were also identified by infrared spectra.

1-Propanol↗
PubMedDate not supplied

[Decrease in the radiation effect in the lymphoid organs of animals adapting to altitude].

Adaptation to altitude hypoxia exerts a positive effect on the cell density of lymph organs of gamma-irradiated animals. It also reduces radiation degradation of DNA, its availability to DNase in the nuclear chromatin and disorders in the activity of DNA polymerases. The role of inhibition of radiation-induced degradation of chromatin DNA in the protective effect of altitude adaptation on the cell density of lymph organs is discussed.

Adaptation, Physiological↗
PubMedDate not supplied

[Nucleic acids of the lymphoid cells of the pregnant rat subjected to space flight and its progeny].

The space flight effect on the synthesis of nucleic acids in spleen lymphocytes in pregnant rats and their offspring was investigated. In addition to the inhibition of the DNA replicative function previously detected in males, activation of RNA synthesis was seen in the pregnant females. Such changes did not develop in the synchronous mockup controls. The 30-day and 100-day old pups of the rats flown in space during the last third of their pregnancy showed no changes in the DNA replicative function. The 100-day old animals displayed only a slight, when compared to the vivarium controls, decline of RNA synthesis which was produced by concomitant factors rather than by microgravity per se. It is supposed that microgravity-induced activation of RNA synthesis in spleen lymphocytes of pregnant rats is associated with the involvement of these cells in adaptive trophic processes that are to maintain plastic homeostasis of the fetus in an unusual environment.

Animals↗
PubMedDate not supplied

[The role of carbonyl-amine reaction in biological systems and food technology (review of the literature)].

Modern ideas about the role of the carbonyl-amine reaction in biochemical systems are reviewed. Some details recently found of the mechanisms of the initial steps of the reactions are considered. The pathways of the formation of numerous by-products are discussed which are very important for taste and aroma of some foodstuffs. Data are presented on nonenzymatic glycosylation of proteins in living organisms, which causes disturbances in their vital functions, diseases and aging. Possible chemical structures of "links" between sugars and protein polypeptide chains, as well as nucleic acids derived from glycosylation are considered. References concerning properties of melanoidins are presented.

Aging↗
PubMedDate not supplied

[Low molecular weight metabolites produced by various Penicillium species].

Low-molecular weight volatile metabolites produced by Penicillium farinosum, P. citrinum, P. camemberti and P. chrysogenum were investigated. During first 40 days of cultivation the fungi produced mainly C-8 compounds, and later mainly 2-hexenal was synthesized. Addition of 0.1% linoleic acid significantly stimulated the secretion of volatile metabolites. P. citrinum and P. farenosum produced large quantities of geosmin.

Aldehydes↗
PubMedDate not supplied

Interpretation of the results of investigating molecular fossils.

The difficulties and possible errors in interpreting the results of investigating molecular fossils within the scope of the problem of chemical evolution and origin of life on the earth are examined. These difficulties can be largely overcome on the basis of modeling processes of the transformation of organic matter under different geological conditions.

Amino Acids↗