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Biomedical subjects

I A Egorova

Publications and source records attributed to I A Egorova.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

[The social hygiene aspects of monitoring and assessing the efficacy of the activities of treatment and prevention institutions].

The proposed system for evaluating the quality and efficiency of medical care, including universal parameters with quantitative expression, allows the comparison, evaluation, and mathematical processing of these parameters. The method helps detect violations of medical technologies, irrational utilization of resources, directly compare the results and use them for preliminary testing of validity of the managing decisions.

Efficiency, Organizational↗
PubMedDate not supplied

[Excretion of aldosterone in the urine, renin activity in the plasma and some indices of the metabolism of potassium and sodium in patients with the iodiopathic edema syndrome].

It appeared that urinary aldosterone excretion was increased in 23 of 35 patients with a syndrome of idiopathic edema. The plasma renin activity failed to differ from the norm; consequently it can be supposed that the renin-angiotensin system played no significant role in the mechanism of hyperaldosteronism development in this form of pathology. A negative sodium balance was revealed in some of the patients with an edema syndrome and hyperaldosteronism.

Adult↗
PubMedDate not supplied

[The contractility of the lower portion of the esophagus as a criterion of the adequacy of anesthesia].

It has been found that narcotic analgesics (morphine, fentanyl and dipidolor), inhalation anesthetics (phthorothan and frilen) and an intravenous anesthetic calypsol suppress lower esophageal contractility. Comparison of lower esophageal contractility with hemodynamic parameters and ACTH and cortisol blood plasma content have revealed a direct correlation. It is concluded that the method of dynamic control over lower esophageal contractility may be an objective test controlling the adequacy of anesthesia during various surgical interventions.

Anesthesia↗
PubMedDate not supplied

[The prostacyclin-thromboxane system and platelet hemostasis following aortocoronary bypass with an uncomplicated postoperative course].

Prostacyclin-thromboxane system and platelet hemostasis have been studied in 56 patients upon aortocoronary bypass surgery with uncomplicated early postoperative period. It has been established that cardiopulmonary bypass surgery leads to a considerable increase in 6-keto-PGF1 alpha and TXB2 levels per platelet, as compared to preoperative values. By hour 18 postoperatively 6-keto-PGF1 alpha to platelet number ratio returns to baseline, while TXB2 to platelet number ratio remains higher than preoperative values, which determines a shift in 6-keto-PGF1 alpha to TXB2 ratio towards TXB2, thus ensuring, probably, enhanced platelet aggregation properties. Thrombocytopenia, a decrease in platelet aggregation properties and elevated blood plasma level of beta-thromboglobulin were observed upon aortocoronary bypass surgery. By hour 18 postoperatively the number of platelets increased significantly, their aggregation properties were enhanced, beta-thromboglobulin blood plasma level was reduced, however, the parameters under study did not reach normal values at that time. Increased levels of 6-keto-PGF1 alpha and TXB2 per platelet in the early postoperative period are considered an important component of compensatory-adaptive body reactions directed to normalization of the damaged body functions, namely hemostasis and microcirculation.

6-Ketoprostaglandin F1 alpha↗
PubMedDate not supplied

[The prostacyclin-thromboxane system and thrombocytic-vascular hemostasis in patients with ischemic heart disease in the preoperative period].

Prostacyclin-thromboxane system (PTS) and platelet-vascular hemostasis have been studied in the preoperative period in 35 ischemic patients. A marked PTS disbalance with predominance of plasma thromboxane has been found. It has been established that in patients with postinfarction cardiosclerosis plasma prostacyclin content was significantly higher than in patients without myocardial infarction. The study of platelet function has demonstrated normal platelet aggregation rate and an increased level of beta-thromboglobulin in the blood of ischemic patients. Acetylsalicylic acid (250 mg/daily) was used for the correction of the disturbances observed, it reduced platelet aggregation, but had no effect on PTS and platelet release.

Adult↗
PubMedDate not supplied

[Hygienic evaluation of the combined effect of portable water chloroform].

The paper considers the significance of complex entrance of chloroform from portable water into the human body (enterally, inhalationally, and through the intact skin). It shows it necessary to toughen the maximum permissible concentration (MPC) of chloroform in the portable drinking, by taking into account of the multiplicity of routes of its action on the population. The authors present the results of their own investigations of the levels of chloroform in the air of bath and shower rooms before and after taking a shower and filling the bath with water, as well as in the airspace layer above the water of an indoor swimming pool, by using chromatographic mass-spectrometry.

Carcinogens↗
PubMedDate not supplied

[The status of the renin-angiotensin-aldosterone system in patients in the early period following aortocoronary bypass surgery].

The state of renin-angiotensin-aldosterone system has been studied in 43 patients after aortocoronary bypass surgery. Renin activity, angiotensin II and aldosterone content have been studied, using radioimmunoassay, in comparison with hemodynamic findings and water-electrolyte balance parameters. The study was performed in patients with uncomplicated postoperative period and in patients with acute circulation disturbances just after surgery and 3, 6, 18 and 48 hours after surgical intervention. It has been shown that in uncomplicated postoperative period there is a 6-8-fold increase in plasma renin content and a 1.5-2-fold increase in aldosterone concentration. Despite an increase in aldosterone activity clinical signs of hyperaldosteronism became evident by the 18-48th hour postoperatively. A persistent increase in renin-angiotensin-aldosterone system activity in patients with acute circulation disturbances is considered as a compensatory body reaction directed at stabilization of the circulating blood volume and heart performance.

Adult↗
PubMedDate not supplied

[Changes in regional pulmonary hemodynamics and levels of vasoactive substances in man in a state of antiorthostatic hypokinesia].

A comparative evaluation of rheographic changes in regional pulmonary hemodynamics and renin-angiotensin and kinin-kallikrein activities was carried out on 9 volunteers exposed to antiorthostatic hypokinesia (-8 degrees) for 14 days. It was found that pulmonary circulation shifted in the apical direction due to increase in arterial tonicity and phasic variations of venous lumen. During the study blood renin increased significantly (P less than 0.05) whereas prekallikrein and kallikrein inhibitor varied insignificantly. It was concluded that the renin-angiotensin system played and important role in the changes of functional topography of pulmonary circulation in simulated microgravity conditions.

Aprotinin↗