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I A Toropchina

Publications and source records attributed to I A Toropchina.

11 recordsLinked to original sources
PubMed1985

[Analysis of 99mTc-HIDA kinetics using an adaptive model].

The paper is concerned with the results of assaying hepatocyte function on the basis of an adaptive pharmacokinetic model worked out by the authors. Hepatoscintigraphy with 99mTc-HIDA was used in 3 phases: the vascular phase of RP transport (the 1st min of investigation, scintigrams with a 2 s interval), the parenchymatous phase (with a 20 s interval in subsequent 10 min), the biliary phase (with a 3 min interval). The hepatocytic phase of 99mTc-HIDA transport was evaluated on the basis of the adaptive 5-compartmental model calculating the value of transport constants. In terms of differential diagnosis, the intercompartmental constants K1,2 (blood-liver) and K2,1 (liver-blood) turned out to be the most informative. Thus the assaying of hepatocyte transport function using the proposed adaptive model helps to define the degree of liver involvement in a pathological process, to choose the therapeutic tactics and method, to evaluate its efficacy and to predict possible complications.

Biliary Tract Diseases↗
PubMed1977

[Study of a multifield equivalent cardiac generator].

The electric field of the isolated dog heart immersed into a liquid volumetric conductor was subjected to a thorough investigation. Measurements and subsequent calculations showed that in precordial leads the quantitative description of the cardiac generator by a multipole equivalent generator of the 1st order (dipole) is rough approximation. Addition of a multipole component of the 2nd order (quadripole) to the equivalent generator increases but relatively little the accuracy of description. It is suggested that in this problem the multipole expansion proves to be a slowly convergent series. For this reason, application of multipole equivalent cardiac generator fixed in the electrical center of the heart in the clinical electrocardiography is to be considered as having no prospect.

Action Potentials↗