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Biomedical subjects

I Ahmad

Publications and source records attributed to I Ahmad.

At least 19 recordsLinked to original sources
PubMed2006

Intrathecal donor lymphocyte infusion for the treatment of suspected refractory lymphomatous meningitis: a case report.

A 43-year-old female with large T-cell non-Hodgkin's lymphoma and central nervous system (CNS) involvement underwent HLA-identical-sibling peripheral blood stem cell transplantation (SCT) during her third complete remission. She presented a possible refractory CNS relapse 5 months after the transplant. She was then treated with intrathecal (IT) donor lymphocyte infusions (DLI). No side effects were observed after three DLI injections. The patient died 13 months later from infectious complications with no evidence of progressive disease. To our knowledge, this is the first case report of IT DLI for possible refractory lymphomatous meningitis.

Adult↗
PubMed2006

Measurements of the half-life of 246Cm and the alpha-decay emission probabilities of 246Cm and 250Cf.

The alpha-decay half-life of Cm246 has been measured to be T(1/2)=4706 (40)yr by means of the alpha-counting of ingrowth activity following the decay of a mass separated source of the Cf250 parent nuclide. The alpha-decay emission probabilities of Cm246 and Cf250 have also been determined with high precision and have been compared with results from previous measurements. A new alpha-decay branch of Cm246 to the 4(+) level of the ground-state band of the Pu242 daughter nucleus has been identified and characterized.

Journal Article↗
PubMed2006

Anomalous isomeric decays in 174Lu as a probe of K mixing and interactions in deformed nuclei.

A K(pi)=13+, 280 ns four-quasiparticle isomer in the odd-odd nucleus 174Lu has been identified and characterized. The isomer decays to both K(pi)=7(+) and K(pi)=0(+) rotational bands obtained from the parallel and antiparallel coupling of the proton 7/2+[404] and neutron 7/2+[633] orbitals. K mixing caused by particle-rotation coupling explains the anomalously fast transition rates to the 7+ band but those to the 0+ band are caused by a chance degeneracy between the isomer and a collective state, allowing the mixing matrix element for a large K difference to be deduced.

Journal Article↗
PubMed2006

K isomers in 254No: probing single-particle energies and pairing strengths in the heaviest nuclei.

We have identified two isomers in 254No, built on two- and four-quasiparticle excitations, with quantum numbers K pi = 8- and (14+), as well as a low-energy 2-quasiparticle Kpi = 3+ state. The occurrence of isomers establishes that K is a good quantum number and therefore that the nucleus has an axial prolate shape. The 2-quasiparticle states probe the energies of the proton levels that govern the stability of superheavy nuclei, test 2-quasiparticle energies from theory, and thereby check their predictions of magic gaps.

Journal Article↗
PubMed2006

40Ca(alpha, gamma)44Ti reaction in the energy regime of supernova nucleosynthesis.

The 44Ti(t1/2=59 yr) nuclide, an important signature of supernova nucleosynthesis, has recently been observed as live radioactivity by gamma-ray astronomy from the Cas A remnant. We investigate in the laboratory the major 44Ti production reaction 40Ca(alpha, gamma)44Ti (Ec.m. approximately 0.6-1.2 MeV/u by direct off-line counting of 44Ti nuclei. The yield, significantly higher than inferred from previous experiments, is analyzed in terms of a statistical model using microscopic nuclear inputs. The associated stellar rate has important astrophysical consequences, increasing the calculated supernova 44Ti yield by a factor approximately 2 over previous estimates and bringing it closer to Cas A observations.

Journal Article↗
PubMed2006

Management of iron deficiency in patients admitted to hospital: time for a rethink of treatment principles.

BACKGROUND: Iron deficiency is very common in patients admitted to hospital. Its management is changing with new insights into iron absorption and therapeutic options. AIMS: The aims of this study were to develop guidelines for the correction of iron deficiency in patients admitted to hospital and to compare these with current practice. METHODS: Based on current published evidence, guidelines were developed. All patients in whom iron deficiency was detected during hospital admission over a 2.5 year period were retrospectively studied. Their management was compared with that of the guidelines developed. RESULTS: Three clinical scenarios were identified--(A) urgent attention to haemoglobin required: blood transfusion followed by i.v. iron recommended, (B) Semiurgent iron repletion: i.v. iron recommended and (C) non-urgent iron repletion: oral or i.v. repletion recommended. A total of 119 patients was identified, age 18-99 (median 77) years, 29% men, and haemoglobin 33-130 (87) g/L. Of 66 given blood transfusion, 17 had subsequent i.v. iron, 25 oral iron and 24 no other form of iron repletion. Of the other 53, nine had i.v. iron, 32 oral iron and 12 had no treatment. Fifty-five per cent of patients were managed according to the proposed guidelines and this occurred less frequently (9%) in those presenting with cardiovascular problems than in those with anaemia, gastrointestinal bleeding or other medical problems (all >60%; P < 0.0001, Fisher's exact test). CONCLUSION: Current management is haphazard, with underutilization of i.v. iron and failure to initiate any regimen for iron repletion being common. It may be time for a change in approach to repletion of iron in ill patients.

Administration, Oral↗
PubMed2006

Safety of iron polymaltose given as a total dose iron infusion.

An audit of the in-hospital safety and tolerability of 401 infusions of iron polymaltose in 386 patients has shown no cases of anaphylaxis or other cardiorespiratory compromise. The infusion was terminated prematurely because of adverse events in six patients (1.6%). No adverse events occurred within the first 15 min of the infusion. Premedication (in 24%) was not associated with fewer adverse events. Fear of anaphylaxis should not inhibit the use of total dose iron infusion and the practices of premedication and of medical supervision during the first 15 min of the infusion should be abandoned.

Adolescent↗
PubMed2006

A novel cationic cardiolipin analogue for gene delivery.

The optically active R and S isomers of cationic cardiolipin analogues (CCA) were synthesized and evaluated as a liposome based transfection reagent. Both isomers form stable liposomes with mean diameters of about 120 nm without any additional lipid ingredients. No significant change in particle size distribution profile was observed over one-month storage at room temperature (20-25 degrees C). The gel to liquid crystalline phase transition temperature (Tm) of cationic liposomes comprised of both R and S isomers was approximately 2 degrees C, as measured by differential scanning calorimetry (DSC). Both isomers also formed stable liposomes when combined with DOPE. In vitro transfection efficiency of the CCA/DOPE liposomes complexed to plasmid DNA was evaluated using a luciferase reporter gene. Both liposomes composed of R and S isomers of the cationic cardiolipin displayed higher transfection efficiency than commercially available Lipofectin. Further in vivo studies are warranted.

Animals↗
PubMed2005

Responses of European eel (Anguilla anguilla L.) circulating phagocytes to an in situ closed pulp mill effluent exposure and its association with organ-specific peroxidative damage.

The effect of bleached kraft pulp mill effluent (BKPME) persistent compounds on phagocyte activities and its organ-specific influence in gill, kidney and liver was studied in European eel (Anguilla anguilla L.). Eels were caged and plunged at 3 different sites-50 m (site 1), 100 m (site 2) and 2,000 m (site 3) away from the end of the closed BKPME discharging channel for 8 and 48 h. Gill, head kidney and peritoneum phagocytes oxidative burst activity (OBA) was measured by the nitroblue tetrazolium reduction assay whereas lipid peroxidation (LPO) in eel gill, kidney and liver was measured by thiobarbituric acid reaction. A significant gill OBA induction was found at 8h on site 2, and on sites 1, 2 and 3 at 48 h exposure. However, in head kidney and peritoneal exudate phagocytes, OBA induction was significant only at sites 2 and 3 after 48 h exposure. In those particular sites, a significant increase in gill, kidney and liver LPO was measured that is assumed to result from OBA induction. Considering OBA and LPO, gill is the most affected tissue compared to kidney and liver. Gill vulnerability towards peroxidative damage was demonstrated at 8h on site 2 and at 48 h on sites 1, 2 and 3, whereas in kidney was observed at sites 2 and 3 only at 48 h. Liver LPO increased at site 2 only after 48 h exposure. Our results demonstrate that the OBA activation pattern in gill and kidney is associated with the induced peroxidative damage extent in those organ, together with water pollution the exposure route, resulting from previous BKPME effluent sediment contamination which may affect the activation pattern of circulating fish phagocytes.

Anguilla↗
PubMed2005

Anterior dental aesthetics: gingival perspective.

The purpose of this series is to convey the principles governing our aesthetic senses. Usually meaning visual perception, aesthetics is not merely limited to the ocular apparatus. The concept of aesthetics encompasses both the time-arts such as music, theatre, literature and film, as well as space-arts such as paintings, sculpture and architecture.

Esthetics, Dental↗
PubMed2005

Anterior dental aesthetics: Dental perspective.

The purpose of this series is to convey the principles governing our aesthetic senses. Usually meaning visual perception, aesthetics is not merely limited to the ocular apparatus. The concept of aesthetics encompasses both the time-arts such as music, theatre, literature and film, as well as space-arts such as paintings, sculpture and architecture.

Age Factors↗
PubMed2005

Anterior dental aesthetics: dentofacial perspective.

The purpose of this series is to convey the principles governing our aesthetic senses. Usually meaning visual perception, aesthetics is not merely limited to the ocular apparatus. The concept of aesthetics encompasses both the time-arts such as music, theatre, literature and film, as well as space-arts such as paintings, sculpture and architecture.

Aging↗
PubMed2005

Structure of the odd-A, shell-stabilized nucleus 253/102No.

In-beam gamma-ray spectroscopic measurements have been made on 253/102No. A single rotational band was identified up to a probable spin of 39/2planck, which is assigned to the 7/2(+)[624] Nilsson configuration. The bandhead energy and the moment of inertia provide discriminating tests of contemporary models of the heaviest nuclei. Novel methods were required to interpret the sparse data set associated with cross sections of around 50 nb. These methods included comparisons of experimental and simulated spectra, as well as testing for evidence of a rotational band in the gammagamma matrix.

Journal Article↗
PubMed2005

Anterior dental aesthetics: facial perspective.

The purpose of this series is to convey the principles governing our aesthetic senses. Usually meaning visual perception, aesthetics is not merely limited to the ocular apparatus. The concept of aesthetics encompasses both the time-arts such as music, theatre, literature and film, as well as space-arts such as paintings, sculpture and architecture.

Attitude↗
PubMed2005

Anterior dental aesthetics: historical perspective.

The purpose of this series is to convey the principles governing our aesthetic senses. Usually meaning visual perception, aesthetics is not merely limited to the ocular apparatus. The concept of aesthetics encompasses both the time - arts such as music, theatre, literature and film, as well as space - arts such as paintings, sculpture and architecture.

Esthetics, Dental↗