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Biomedical subjects

I Altorjay

Publications and source records attributed to I Altorjay.

At least 37 records · Page 2Linked to original sources
PubMed1981

Congenital deficiency of cyclo-oxygenase in a woman with generalized atherosclerosis.

The case of a 52-year-old woman with congenital cyclo-oxygenase deficiency, signs of generalized atherosclerosis and a moderate bleeding tendency is reported. Secondary platelet aggregation was absent. Platelet aggregation induced by arachidonic acid failed totally while that induced by calcium ionophore was normal. No malondialdehyde formation could be detected in her platelet-rich-plasma. The life-long deficiency of cyclo-oxygenase had not protected her from progressive vascular disease. This case suggests that the chronic intake of large doses of aspirin cannot prevent arterial disorders.

Arteriosclerosis↗
PubMed1980

LDH isoenzymes in muscle diseases.

The LDH isoenzyme pattern was investigated in biopsy material of muscles of children suffering from progressive muscular dystrophy and other neurogenic muscular disorders. An absence or pronounced activity loss of LDH 5 was observable in most of the cases. The proportion of subunits was the same in the diseased and the control muscles. Comparing the measured isoenzyme patterns with those expected from a random coupling of of the subunits, a lower percentage of LDH 5 and a higher one of LDH 4 was detected. The cause of the absence of LDH 5 is not a disturbance of M subunit synthesis but the post-translational inhibition of the tetramer forming process of the synthetised M subunits.

Adolescent↗