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I Altunkova

Publications and source records attributed to I Altunkova.

7 recordsLinked to original sources
PubMed1998

Immune mechanisms of the occupational sensitization with methylen-dyphenyl diisocyanate (MDI).

The aim of this study was to objectify and to clarity some mechanisms of the immune response of the professional sensitization with MDI. 26 workers were tested for sensitization of immediate type (ST with a broad set of indoor allergens and serum MDI-IgE) and of delayed type (ST with a standard battery of antigens for cellular immunity and with MDI), also the lymphocyte sub-populations and their functional state by flow cytometric analysis. The most frequent allergic complaints were: rhinits (70%), skin manifestations (53%), conjunctivitis (35%) and initial bronchial asthma in two cases (12%). We found indoor sensitization in 41% and normal cellular immune reactivity in all the workers tested. Specific MDI sensitization of immediate type was found in 28.5% of the workers and of delayed type--in 70% of the workers with allergic complaints. The laboratory immune indices suggest prevalence of cell--mediated mechanisms for the workers with allergic symptoms--production of INF gamma, responding to stimulation and deficient or insignificant production of IL-4, as well as linear correlation between the data for CMI, INF gamma, and IL-4. Our results suggest the participation of more than one mechanism of immune injury in the clinically manifested allergic reactions.

Adult↗
PubMed1993

Role of fibronectin in immune glomerulonephritis.

There is already a considerable amount of evidence suggesting that fibronectin (Fn) plays an important role in the pathogenic process in some forms of glomerulonephritis (GN). It has been postulated that Fn may participate in the progression or regression of glomerular diseases. The Fn is presented in the kidney as a normal component of the mesangium, and it is increased in the expanded mesangium in various forms of GN. This paper reports our efforts to investigate the role of Fn in plasma and kidney in patients with GN. Using monoclonal antibodies against human Fn in the ELISA and immunohistoperoxidase techniques to evaluate Fn, we investigated its quantity in connection with clinical state and morphological findings. We studied 93 patients with GN and 26 renal biopsies. The patients with active forms of mesangial proliferative, membranoproliferative and membranous GN showed increased plasma Fn, and the highest levels were in patients with nephrotic syndrome. Increased tissue Fn correlated with mesangial expansion and with IgG and C3 deposits. We speculate on possible mechanisms of the involvement of Fn in human chronic GN.

Adult↗
PubMed1987

[Cell subpopulations of pyelonephritis patients studied using monoclonal antibodies].

The paper is devoted to a very important problem of immune mechanisms participation in the origination and maintenance of the inflammatory processes in kidneys and urinary ducts. The results from the study of lymphocyte subpopulations, making use of monoclonal antibodies in patients with clinical-laboratory data about chronic pyelonephritis without chronic renal insufficiency, as compared with healthy controls, are reported. Significantly reduced total T-lymphocyte (OKT1+) were established as well as T-helpers lymphocytes (OKT4+) and increased number of monocytes (OKM5+). The values are presented as weighted geometrical mean. A likely interpretation of those data is rather difficult at the present stage.

Adult↗