HLA system & renal diseases.
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Biomedical subjects
Publications and source records attributed to I Andreev.
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A specific conjugate of a hyperimmune serum, obtained from rabbits with the use of the reference Phelps-CELO strain, was employed in a direct immunofluorescence method to investigate more than 320 lamelles with cell cultures infected with 4 field CELO virus strains and the reference Phelps-CELO strain. It is stated this method is specific and prompt for the early diagnosis and identification of adenoviruses (CELO viruses).
Four CELO virus strains, isolated in this country, were used to infect 3-day-old chicks via the trachea, muscularly, orally, subcutaneously, and cerebrally. The chicks were killed on the 2nd, 4th, 6th, 9th and 16th day following inoculation. Material was taken from each chick for morphologic, virologic, and serologic examination. The clinical course of the disease was also followed up. Prior to killing some birds showed infirmity, difficult breathing, slightly expressed diarrhia, going off food, and more sporadically there was fecal mass around the cloaca matting the plumage. Some manifested nervous symptoms similar to those observed in cases of Newcastle disease and encephalitis of birds. In some of the chicks there were hyperemia of the lungs, trachea, and intestins as well as necrotic foci in the liver.
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