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Biomedical subjects

I Angelova

Publications and source records attributed to I Angelova.

30 records · Page 2Linked to original sources
PubMed1985

[Mycoplasma as the causative agent of kidney infections].

A total of 185 patients were investigated for M. hominis and mycoplasmal infection was established in 28 patients. In 2 of the patients mixed infection with E. coli was established and I with Staphylococcus aureus. Fifteen had pyelonephritis and 6--arterial hypertension, without positive data for pyelonephritis. The patients were treated with gentamycin and tetracycline according to the data of antibiograms of the isolated microorganisms. The criteria for admittance of the presence of mycoplasmal pyelonephritis are discussed.

Adolescent↗
PubMed1985

[Causative agents of urologic infections and their sensitivity to the most frequently used antibiotics and chemotherapeutic agents (data from the Clinic for the Therapy of Internal Diseases and Clinical Pharmacology for 1984)].

The causative agents of uroinfections were studied among the patients at the Clinic of therapy of internal diseases and clinical pharmacology during 1984. Significant bacteriuria was established in 279 out of 485 patients, with 1475 urine inoculations performed, 14 with mixed flora. The highest is the share of E. coli--50,5 per cent, followed by Proteus--25,7 per cent. No essential change was established in the microbiological spectrum of the causative agents of uroinfections as compared with that from 1961-1970. Good susceptibility was established to ampicillin but only of Enterococcus, to chloramphenicol of E. coli, Klebsiella, Enterobacter. The susceptibility of all microorganisms to gentamycin and nalidixic acid was very good. The susceptibility to doxycycline was poor. The treatment is recommended only after precise microbiological study.

Anti-Bacterial Agents↗
PubMed1984

[Clinical trial of the herbal combination Dietosan in the species and disperg forms for treating patients with non-insulin-dependent diabetes mellitus].

Clinical studies were carried out on the herb combination Dietosan on 40 patients with diabetes mellitus, insulin-independent type. Twenty patients were treated with the species, and another 20--with the disperg. Eighteen patients, out of both groups have taken glybenclamide. A good compensation of diabetes was attained in 4 patients treated only with species and in 7, treated only with the disperg. Three of those treated with species and glybenclamide were well compensated, and two--of those treated with disperg and glybenclamide. A more distinct reduction of blood sugar was observed among those with good compensation treated with the disperg. No adverse and toxic effects were observed during the treatment with the combination at the clinic.

Aged↗
PubMed1984

[Septicemia caused by Mycoplasma hominis].

A patient with septicemia, caused by Mycoplasma hominis was described. Data were established for pyeloureteral anomalies in both ureters with disturbed left drainage with hydronephrosis II--II stage. Mixed flora was isolated from urine--Mycoplasma hominis and E. coli. Pure culture Mycoplasma hominis was isolated from the hemocultures. The patient was favourably affected by metacyclin treatment--600 mg daily.

Humans↗
PubMed1982

[Clinical trial of a Plantago major preparation in the treatment of chronic bronchitis].

Plantago major, according to literature data, has expectorant, antiphlogistic, pain-relieving effect. The experimental studies confirmed a spastic effect upon the smooth musculature of bronchi as well. Twenty five patients with chronic bronchitis were examined, with or without spastic character, with light and moderately severe deviations in ventilation indices. The treatment period was 25-30 days. A rapid effect on subjective complaints and objective findings was obtained in 80 per cent. Some indices of external respiration were favourably affected. The preparation is with a good tolerance, with no toxic effect on gastrointestinal tract, liver, kidneys, hemopoiesis.

Adult↗
PubMed1981

[Treanntment of duodenal ulcers and gastroduodenitis with a herbal combination of Symphitum officinalis and Calendula officinalis with and without antacids].

A total of 170 patients were treated--137 only with the herb combination (78 with duodenal ulcer and 59 with gastroduodenitis), 33--with the herb combination together with antacid (21 with duodenal ulcer and 12 with gastroduodenitis). As a result from the treatment, the spontaneous pains disappeared in 90 per cent of the patients--in the group with and in the group without antacid, the dyspeptic complaints faded in over 85 per cent but in the patients, treated with herbs and antacid the mentioned complaints disappeared several days earlier. The palpitation pains, in both groups, disappeared in more than 90 per cent of the patients within the same time. Gastric acidity, in both groups, showed a statistically insignificant tendency to decrease prior and post treatment. The gastroscopically control revealed that the ulcer niche, in both groups, was healed in almost the same percentage of the patients.

Adolescent↗
PubMed1981

[Treatment of chronic colitis with an herbal combination of Taraxacum officinale, Hipericum perforatum, Melissa officinaliss, Calendula officinalis and Foeniculum vulgare].

Twenty four patients with chronic non-specific colitis were treated with a herb combination. As a result from the treatment, the spontaneous and palpable pains along the large intestine disappeared in 95.83 per cent of the patients by the 15th day of their admission to the clinic. Defecation became daily in the patients with obstipation syndrome, but a combination of Rhamus frangula, Citrus aurantium, C. carvi was added to the herb combination already indicated. Defecation was normalized in patients with diarrhea syndrome. The pathological admixtures in feces disappeared.

Adult↗
PubMedDate not supplied

Drug-induced psoriasis. Recognition and management.

As psoriasis is a common skin disorder, knowledge of the factors that may induce, trigger, or exacerbate the disease is of primary importance in clinical practice. Drug intake is a major concern in this respect, as new drugs are constantly being added to the list of factors that may influence the course of the disease. Drug ingestion may result in exacerbation of pre-existing psoriasis, in induction of psoriatic lesions on clinically uninvolved skin in patients with psoriasis, or in precipitation of the disease in persons without family history of psoriasis or in predisposed individuals. In view of their relationship to drug-provoked psoriasis, therapeutic agents may be classified as drugs with strong evidence for a causal relationship to psoriasis, drugs about which there are considerable but insufficient data to support the induction or aggravation of the disease, and drugs that are occasionally reported to be associated with aggravation or induction. This review focuses on the most common causative agents for drug-induced, drug-triggered, or drug-aggravated psoriasis, such as beta-blockers, lithium, synthetic antimalarial drugs, nonsteroidal anti-inflammatory agents, and tetracyclines. Latency periods, pathogenetic mechanisms of action, clinical and histologic findings, and management guidelines for each drug are discussed to help clinicians to treat patients with suspected drug-influenced psoriasis.

Drug Eruptions↗
PubMedDate not supplied

A new class of antiulcer drugs. I. Antiulcer effect of AN5, a 4-phenyl-tetrahydroisoquinoline derivative, on different experimental models of ulcer in rats.

The action of AN5 on experimental models of gastric ulcers induced by water-immersion stress, indomethacin and reserpine, or by pylorus ligation in rats has been studied. AN5 supresses the formation of ulcers in all experimental models. The strongest antiulcer effect is shown in relation to water-immersion stress-induced ulcers. From the broad pharmacological studies of AN5 on this model it can be seen that even a dose of 0.100 mg/kg has a high antiulcer activity. The increase of the dose leads to a regular increase of the antiulcer activity, the highest suppression of the ulcer index being reached at a dose of 1 mg/kg (86.15%). The comparative studies with ranitidine and cimetidine on the same experimental models of gastric ulcers show that AN5 possesses an antiulcer activity many times higher than that of the above-mentioned drugs.

Animals↗