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Biomedical subjects

I Assmann

Publications and source records attributed to I Assmann.

At least 37 records · Page 2Linked to original sources
PubMed1987

[Clinical and paraclinical findings on status following prosthetic heart valve replacement with special reference to the behavior of pulmonary pressure].

Retrospectively were evaluated clinical findings of 151 patients with condition after replacement of artificial cardiac valves (Björk-Shiley), who were treated in our department of cardiology in 1986. The patients with mitral valve replacement (MVR) and mitral valve and aortic valve replacement showed the highest rate of individualisation in comparison to aortic valve replacement. 18 patients showed complications and acute deteriorations, respectively, two of which had a fatal course. In 53 patients the bicycle-ergometric exercises were performed with measurement of the pulmonary pressure. Of these patients the majority indeed subjectively improved in their behaviour, however, the objective exercise tolerance was altogether low and the rate of invalidisation increased in comparison to the preoperative rate. The pulmonary pressure at rest in the majority of the patients was reduced mostly in dependence on the initial values. Increases appeared only sporadically. Under exercise, however, particularly the patients with mitral valve replacement showed pathological increases of pressure. Altogether the best results showed patients with aortic valve replacement also with regard to the shrinking of the radiologically established size of the heart.

Adolescent↗
PubMed1987

[Clinical aspects, diagnosis, therapy and course of unstable angina pectoris].

It is reported on 27 patients aged 32-77 years with an unstable angina pectoris, including coronary spasm. All patients showed an anamnesis of less than 3 months, nearly the half of less than 24 hours. The resting electrocardiogram during the attack was pathological in 22 patients, 7 patients showed a Prinzmetal reaction and 11 patients showed intermittent ventricular dysrhythmias. The exercise electrocardiogram in the stable phase was pathological in 16 of 17 patients. Of 23 patients who underwent a selective coronary angiography with laevocardiography 9 patients each showed a disease of one vessel and three vessels, respectively, and 5 patients a disease of two vessels. Only nearly 50% of the patients could be stabilized medicamentously (nitrates, calcium antagonists, rarely beta-blockers). In three patients still during the unstable phase a surgical revascularization was carried out, in 11 patients after stabilization. Five patients suffered an early infarction; one of them died. Altogether, the unstable angina pectoris is even nowadays to be regarded as a clinical picture with a relatively bad prognosis, which demands rapid action.

Adult↗
PubMed1987

[Mechanocardiography findings and hypertrophic and dilated cardiomyopathy].

On 71 patients with hypertrophic cardiomyopathy with and without measurable left-ventricular outflow tract gradients, with typical and atypical morphology (ascertained by catherisation of the right and the left heart and angiocardiography as well as selective coronarography) as well as also by catheter investigation including the cardiography of ascertained dilatative cardiomyopathy in 19 patients mechanocardiographic (systolic time analysis from the carotid sphygmogram as well as parameters of the diastole from the apex cardiogram) investigations concerning the heart function and the course were performed. The hypertrophic cardiomyopathy is characterized particularly by a restricted diastolic function, when a good or very good pumping function is present. On the basis of the mechanography the dilatative cardiomyography particularly shows a bad pumping function with also restricted diastolic function. The two forms of cardiomyopathy are clearly to be separated by means of the methods used. Prognostic statements are possible only with reservation. Apexcardiographic parameters are here better suitable.

Adolescent↗
PubMed1985

[Long-term therapy with amiodarone in tachyarrhythmias--report on various experiences with special reference to its side effects].

In 23 patients with symptomatic severe supraventricular and ventricular tachyarrhythmias the effectiveness and the side effects of a long-term therapy with the class III antiarrhythmic drug Amiodarone (Cordarone) in a dosage of 100-800 mg/die in monotherapy and combination therapy were investigated. In these cases it proved to be an excellently effecting antiarrhythmic drug in tachycardiac dysrhythmias at atrial and ventricular level with an altogether good tolerance. In 16 patients side effects appeared and above all concerned corneal micro-deposition without any clinical symptoms (10 patients). In 3 patients nuclear-medically insignificant changes of the function of the thyroid gland were found--also without clinical relevance. Three times a photosensitisation was conspicuous, only in one patient the therapy was finished on account of epigastric trouble after three months. Av-blockings of higher degree, particularly with bundle-branch block and severe sinus bradycardias as well as disturbances of the thyroid function are regarded as contraindications without preceding pacemaker implantation.

Adult↗
PubMed1984

[Long-term therapy of hypertrophic obstructive and non-obstructive cardiomyopathy with nifedipine in comparison to propranolol].

On 24 patients with ascertained hypertrophic obstructive cardiomyopathy and hypertrophic non-obstructive cardiomyopathy in a long-term experiment over 6 months the effect of 30 mg Nifedipin per day on subjective and objective parameters was investigated and compared with Propranolol. The subjective symptoms were in a larger extent improved by Propranolol than by Nifedipin. In contrast to Propranolol Nifedipin had no influence on the systolic function on the basis of the systolic time intervals. The diastolic heart function, assessed by means of the cardiographic criteria of the apex, was improved by Nifedipin in circa the same extent as by Propranolol. The results altogether allow the conclusion that the application of Nifedipin seems to be reasonable in patients with contraindication to beta-receptor-blockers or Verapamil or when there is no reaction to these preparations. When there is no satisfying result, a combination with beta-blockers should also be attempted.

Adolescent↗
PubMed1983

[Pathophysiology of ventricular tachyarrhythmias].

On 11 patients at the age between 11 and 60 years with ventricular tachyarrhythmias (6 times relapsing ventricular tachycardia, twice relapsing ventricular fibrillation, 3 times massive polytopic ventricular extrasystoles) complex intracardiac electrophysiological and haemodynamic examinations, including heart catheterization with angiography (and in 6 patients selective coronarography) were performed. In no case we succeeded in evoking a ventricular tachycardia by stimulation. Also the spontaneous long-lasting ventricular tachycardias could not be interrupted by a single or manifold stimulation. By multiple right- and left-ventricular potential deviations we succeeded in differentiating the ventricular tachycardia and ventricular extrasystoles, respectively, according to the place of origin in all patients. As cause of the ventricular tachycardia and of the ventricular fibrillation, respectively, in 4 patients an ectopic focus with increased impulse formation, in the other patients, apart from an increased ectopic automatism, also reentry tachycardia is assumed.

Action Potentials↗