[Infections in foreign adoptive children].
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Biomedical subjects
Publications and source records attributed to I Atterholm.
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22 patients with various gram-negative infections were treated with tobramycin at a dose of approximately 3 mh/kg body weight/24 h for 7 to 53 (mean 16) days. Therapy was monitored with determinations of drug serum concentrations and renal and audio-vestibular function tests. In 16 patients either cure of clinical improvement were achieved. Two patients did not improve. In another 4 patients the effect of tobramycin therapy could nto be evaluated. One patient exhibited a subclinical vestibular dysfunction and one patient experienced transient tinnitus. In one patient, slight but clinically significant renal impairment occurred.
An outbreak of repeated chills, fever, respiratory-tract symptoms, and muscle pain, starting 4 h after a hot bath, involved 56 persons, nearly all of whom lived in an area supplied with water from the same source. The symptoms lasted for 6--15 h. A polymorphonuclear leucocytosis was a feature of the illness. The causal agent, which has not yet been identified, was found to enter the body by inhalation. Bacteriological and chemical studies and investigation of the water for endotoxins and algae revealed nothing unusual.