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Biomedical subjects

I Aursnes

Publications and source records attributed to I Aursnes.

At least 19 recordsLinked to original sources
PubMed1992

Low dose infusion of adenosine diphosphate prolongs bleeding time in rats and rabbits.

The effect of intravenous infusion of adenosine diphosphate (ADP) on haemostatic and thrombotic mechanisms was studied in rats and rabbits. Infusion of ADP (0.2-1 microMol/kg/min) in rabbits prolonged the skin capillary bleeding time threefold after between 1/2 and 2 hours of infusion. Prolongation of the bleeding time was parallelled by reduced in vitro sensitivity of platelets to ADP in citrated platelet-rich plasma. No major changes in respiratory frequency and heart rate were observed. On the other hand, infusion of adenosine (1 microMol/kg/min) did not affect the bleeding times. Intravenous ADP (0.1 microMol/kg/min) significantly prolonged the bleeding time in anaesthetized rats. Platelet and red cell counts before and during the ADP infusion indicated slight, reversible platelet aggregation. After 75 min the ratio between red cells and platelets resumed a steady pre-experimental level. Platinum wires placed in the abdominal aorta of rats to monitor thrombus formation during ADP infusion indicated an antithrombotic effect of prolonged, low dose infusion of ADP. Since infusion of adenosine did not affect the haemostatic mechanisms, these observations may indicate that ADP infusion desensitized the platelet responsiveness to aggregating stimuli in vivo, and/or that prostacyclin production by endothelium was stimulated by infusion of ADP.

Adenosine↗
PubMed1992

[What can be achieved by treatment with antihypertensive agents? Report from a hearing].

Today it is considered a primary goal to reduce morbidity and mortality from stroke. It will probably also be possible to reduce other pressure-related illnesses, such as heart failure and renal failure. Coronary morbidity is influenced to some extent only, and involves risk of over-treatment. There is most probably a J-shaped relationship between achieved reduction of pressure and mortality. Treatment with drugs is considered when diastolic pressures exceed 90 mm Hg, provided that the patient has been observed when treated in other ways than by drugs for several months. If no other risk factors are present, 5-10 mm Hg higher diastolic blood pressure levels can be accepted. However, all patients with diastolic pressure above 100 mm Hg should be treated. In patients with coronary disease it is advisable not to lower diastolic blood pressure below 85 mm Hg. One should hesitate to give antihypertensive drugs to individuals with high pressures at the doctor's and normal pressures at home. They should preferably receive intense non-drug treatment aimed at reducing total cardiovascular risk.

Antihypertensive Agents↗
PubMed1991

[Effect measures and confidence intervals].

In order to exemplify the use of effect measures and confidence intervals in epidemiology, it is assumed that a group of patients treated with antiflogistic drugs were compared by repeated gastroscopy with a control group. The effect measures "incidence rate difference" and "incidence rate ratio" are used to compare ulcer incidence in the two groups of patients, and the corresponding confidence intervals are stated. On the other hand, if the registered parameter is prevalence rather than incidence rate, for instance the occurrence of prepyloric erosions at a certain time, the effect measures employed are "risk difference" and "risk ratio". An alternative to the latter is "odds ratio".

Confidence Intervals↗
PubMed1991

Degree of coronary artery disease predicted by exercise testing.

The ability of exercise testing to predict the extent of coronary artery disease was examined in 268 male patients undergoing both coronary angiography and bicycle testing with electrocardiography before coronary artery bypass surgery. When maximal ST-depressions limited by symptoms increased from 0 to 4 mm or more, the percentage of patients with 'serious' coronary disease, defined as either triple vessel disease or left main stem stenosis, increased from 50% to 80% (P = 0.0001). The patients in the lowest third of physical work capacity showed only a slightly increased risk of serious disease. This tendency was abolished in patients who were using beta-blockers, whereas the relationship between ST-depression and disease was not affected by this medication. The probability of finding left main stem stenosis in a patient increased from 5 to 30% with increasing ST-depression: beta-blockers did not affect this relationship, but there was no additional predictive effect of implicating the level of physical work capacity. It is concluded that traditional electrocardiography during exercise is of value when selecting patients for angiography, but that the physical work level obtained during the test does not predict the degree of coronary pathology.

Adrenergic beta-Antagonists↗
PubMed1990

[Drug therapy of acute myocardial infarction and unstable coronary syndrome].

Questionnaires were sent to 61 Norwegian hospitals treating acute coronary syndromes, and 90% replied. Thrombolytic drug treatment is now the routine when the history of chest pain is short and ischemia appears in ECG. Use of glyceryl trinitrate and beta blocking drugs varies considerably, as does the use of oral anticoagulants and platelet inhibitors. Practice also varies in unstable angina. However, a combination of aspirin, intravenous nitrate, and betablockers is common. Several treatment regimens have an uncertain scientific foundation. The varying practice reflects international scientific debate.

Adrenergic beta-Antagonists↗
PubMed1990

[Drug therapy of acute coronary syndrome. Summary of a hearing arranged by the Norwegian Cardiologic Society and the Institute of pharmacotherapy].

Acute coronary syndrome is defined as unstable angina or acute myocardial infarction. A discussion on drug treatment of these conditions was arranged by the Norwegian Society of Cardiology and the Department of Pharmacotherapeutics, University of Oslo, soon after preliminary results of the GISSI II study were available. Relatively simple rules were agreed for the use of analgetics, nitrates and fibrinolytic agents. The last are used only after established myocardial injury. Consensus was also reached on the restricted use of calcium antagonists, inotropic agents and diuretics. There was disagreement concerning the dosage of heparin and the exact use of betablockers, aspirin, warfarin, ACE-inhibitors, magnesium and antiarrhythmics.

Adrenergic beta-Antagonists↗
PubMed1990

[Mastitis in general practice. Is bacteriologic examination useful?].

For a period of 22 months, postpartial women in Oslo were asked to consult one of several specific general practitioners in the event of mastitis. Clinical symptoms, bacteriological findings in breast milk and treatment were recorded in 43 patients. Patients with a favourable (n = 35) and with an unfavourable outcome (n = 8) defined as abscess, relapse and/or relief of symptoms after more than seven days, were compared. Unfavourable outcome was characterized by higher score of clinical symptoms and a higher isolation frequency of Staphylococcus aureus. The occurrence of fever did not differ between the groups. Bacteriological findings in milk from both breasts were compared with the findings from 100 milk donors. Staphylococcus aureus was more frequently isolated in milk from affected breasts than from unaffected and control breasts (17/40 versus 4/40 versus 4/100). Most of the Staphylococcus aureus strains (70%) were betalactamase producers. Coagulase negative staphylococci were a frequent finding in all milk samples, whereas Gram-negative bacteria were frequent only in the controls. The presence of pathogenic bacteria, as well as high bacterial counts, were associated with a higher number of symptoms. However, the predictive value of the bacteriological examination was low. Our study indicates that bacteriological examination of breast milk is justified only in patients with severe, acute symptoms and recurrences when betalactamase producing Staphylococcus aureus are suspected.

Family Practice↗
PubMed1989

[ACE inhibitors].

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Angiotensin-Converting Enzyme Inhibitors↗