[How does polyvinylpyridine N-oxide decrease the cytotoxic effect of SiO2 particles?].
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Animals↗
Biomedical subjects
I B Deeva
Publications and source records attributed to I B Deeva.
[Major molecular mechanisms determining the cytotoxicity of fibrogenic dusts].
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Animals↗
[Decomposition of H2O2 by human cataractous lenses].
It was shown that human lens opacity was accompanied by the decrease in the lens ability to cleave H2O2 (10(-4) M), added to the lens-surrounding medium. The rate of peroxide decomposition at the stage of mature cataract in isolated human lenses was 3.5 times lower than that of the control human lenses (transparent lens, initial cataract). Specific catalase inhibitor--3-amino,IH-1,2,4-triazole showed no significant influence on the rate of H2O2 cleavage. Reduced glutathione (10 microM) added to the lens incubation medium induced a sharp increase in the rate of H2O2 detoxication. The results indicate that reduced glutathione metabolism is of primary importance in the maintenance of anti-peroxide activity in the lens.
Amitrole↗
[Biological significance of the surface properties of fibrogenic dusts].
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Animals↗
[Spin label study of structural changes at different depths of phospholipid membranes after their peroxidation].
Changes of structural organization of liposomal phospholipid membranes, after their Fe2+-induced peroxidation were studied at different depth using nitroxyl derivatives of stearic acid. It was established that during Fe2+-induced lipid peroxidation a strong rise in lipid polarity accompanied with immobilization of acyl chains of phospholipids at the depth of 0.6-0.8 nm from the surface was measured. At the same time no significant changes in the structural organization were seen at the depth of 20-22 nm.
Electron Spin Resonance Spectroscopy↗