Biomedical subjects
Publications and source records attributed to I B Ershova.
As many as 617 patients with measles were examined. Of these, 306 subjects presented with a complicated form of the condition. A way is suggested for the prognostication of complications, relying on clinical factors and on a method for non-uniform sequential statistical procedure. A correct prognosis involving a diagnostic table made up 61%.
Immunological indices were compared in 138 patients with angina and concomitant bronchitis; 86 of them received antibiotics, splenin and vylosen; 52 received routine treatment. It was established that use of a combination of splenin and vylosen produces a pronounced immunodulating effect in primary immunodeficiency states due to recurrences of angina and concomitant pathology of the bronchopulmonary in workers of a large industrial enterprise. Immunomodulators are indicated in the treatment of repeat and relapsing angina, especially in the presence of concomitant bronchitis.
Materials are submitted concerning the use of thymohexine in the treatment of measles. Efficacy of thymohexine in 133 children with grave and complicated forms of measles was assessed. Thymohexine was found out to reduce the duration of the infectious toxicosis and local inflammatory events. Under the influence of the above drug the total counts of T- and B-lymphocytes (CD11, CD8, CD4, CD22) returned to normal as did the immunoregulatory index (D4/CD8), levels of circulating immune complexes, their molecular composition.
The association of the HLA system with measles morbidity in transmissive children was studied. The study revealed that the ability of contacting measles has genetic predisposition expressed in positive or negative association with different antigens of the HLA system. This association has polygenic character and determines the clinical course of measles.