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Biomedical subjects

I B Voronov

Publications and source records attributed to I B Voronov.

18 recordsLinked to original sources
PubMed1991

[The effect of the heart rhythm on the respiratory rhythm in anesthetized cats].

In 27 anesthetized cats, histograms of the ECG respiratory cycle phases distribution revealed that in 89% of cases the histograms were significantly non-uniform. The heart rate (HR) was relatively constant: high probability of respiratory phases switching was conditioned by the HR influences on respiratory rhythm. The intensity of such influence was about 10% on the average. The influence of cardiac rhythm on respiratory rhythm was caused by relatively weak signals. The closer the relation of HR to respiratory rate (f) to whole figures, the higher the probability of cardiac rhythm influence on respiratory phases switching.

Anesthesia↗
PubMed1991

[The effect of the heart rhythm on a shift in the respiratory phases in cats].

The probabilities of inspiratory on- and off-switches during the ECG's R-R interval were studied in 27 anesthetized cats. The tops of the high-probability peaks were located in the middle or in the second half of the R-R interval for the inspiratory off-switches. The effect of heart rate on the respiratory rhythm seems to be transmitted through the inspiratory off-switch mechanism. The high-probability peaks of inspiratory on-switches are subsequent to the inspiratory off-switch peaks.

Animals↗
PubMed1985

[Features of the temporal structure of the respiratory cycle in the Tourette syndrome as a possible reflection of intensified dopaminergic processes].

The effect of dopamine blockers (chlorpromazine and haloperidol) and the dopaminomimetic piribedil on the structure of the breathing cycle was studied under conditions of the clinical employment of the drugs. It was found that piribedil increased the inspiration fraction (IF) in the respiratory cycle whereas neuroleptics diminished it. Twenty-six children with Tourette's syndrome (TS) and 24 with a temporal form of epilepsy were examined. Patients with TS showed two specific features of respiration regulation: a greater value of IF and a greater variability of respiratory parameters. Taking into account the pharmacological data, an increase in IF is considered as physiological evidence of dopaminergic hyperfunction in TS whereas a greater variability of respiratory parameters may reflect the paroxysmal activity of deep cerebral structures.

Adolescent↗
PubMed1984

[Pharmacological analysis of the regulation of the phase duration of the respiratory cycle].

The oxotremorine, arecoline, physostigmine, armine, hyoscine and amphetamine affected the inspiratory (Ti) and expiratory (Te) duration as well as the Ti/(Ti + Te) ratio in 20 anesthetized cats. M-cholinopositive agents decreased the Ti/(Ti + Te) ratio due to shortening of inspiratory duration and simultaneous lengthening of expiratory one. Changes in the blood pressure and Ti/(Ti + Te) patterns appeared to be similar. The difference between our data and the data obtained by means of iontophoretic application of the agents to identified respiratory neurons might be accounted for by the fact that the routine technique used to identify respiratory neurons was unreliable.

Animals↗
PubMedDate not supplied

Analysis of the action of the neuropeptide-inducing delta-sleep in cats and white rats.

Suboccipital administration of the oligopeptide to adult cats and white rats in a dose of 15 and 20 micrograms/kg induces the appearance of electrographic (delta-sleep) and behavioral sleep within 15-25 min. Administration of the oligopeptide induces a substantial increase in the thresholds of the response of the EEG to phonostimulation. A substantial lag (50-90 min) in the onset of paradoxical sleep is noted, which is considered by the authors as a manifestation of inhibition, exerted by the neuropeptide on the further development of the sleep mechanisms. On the basis of the data obtained it is concluded that natural sleep and that induced by the neuropeptide are nonequivalent.

Animals↗
PubMedDate not supplied

[The effect of arecoline on the structure of sleep and wakefulness in hens].

In chronic experiments on hens, studies have been made on the role of cholinergic mechanisms in regulation of the cycles "awakefulness-sleep". A cholinomimetic, arecoline, was used which stimulates M-cholinoreceptive brain neurons. Arecoline was injected intramuscularly in a dose 0.2 mg/kg of body weight. It was shown that cholinergic mechanisms are involved into the formation of "awakefulness-sleep" cycles in hens. Activation of these mechanisms facilitates paradoxical stage of sleep and expecially such its components as rapid eye movements, the decrease of tonus in neck muscles and, presumably, ponto-geniculo-occipital discharge. Arecolin affects not only the structure of paradoxical sleep, but both the awakefulness and mechanisms of slow-wave sleep stage.

Animals↗
PubMedDate not supplied

[Interaction of the cholinergic and adrenergic systems during generation of 2 forms of sleep in Rana temporaria frogs and Emys orbicularis turtles].

Universal role of cholinergic mechanisms has been revealed in triggering of activation during two forms of sleep in cold-blooded animals--the primary sleep (fish, amphibians) and intermediate sleep (reptiles). The intensity of activation phenomenon in the brain during these forms of the sleep is controlled by functional interaction between cholinergic and adrenergic systems of the brain. It is suggested that the vegetative nervous system is the most ancient regulatory system of the cycle awakefulness-sleep in vertebrates. The observed activation phenomenon, developing during sleep in the cold-blooded animals, with respect to its biological role plays presumably the same function as paradoxical stage during slow--wave sleep in warm-blooded animals.

Adrenergic Fibers↗
PubMedDate not supplied

[Muscarin-sensitive cholinoreactive systems in the respiratory center].

Muscarinic cholinergic drugs (arecoline, oxotremorine) which can easily overcome the blood-brain barrier inhibit the action potentials of the phrenic nerve in anesthetized or decerebrate curarized cats after a selective blockade of peripheral muscarinic cholinoreceptors with quaternary anticholinergic drugs (oxyphenonium, benzilycholine). These inhibitory effects are abolished by drugs blocking the central muscarinic cholinoreceptors (atropine, scopolamine, benactyzine). This suggests the existence of muscarinic cholinoreceptive neurons in the respiratory center of the cerebral ponto-bulbar region, the said neurons inhibiting the activity of the inspiratory motonerons.

Animals↗
PubMedDate not supplied

[Analysis of the action of a neuropeptide that induces delta-sleep in cats and white rats].

Suboccipital administration of the oligopeptide in a dose 15 or 20 micrograms/kg evokes within 15--20 min the electrographic (delta-sleep) and behavioural sleep in cats and albino rats. Oligopeptide administration significantly increases threshold reactions of EEG to sonic stimulation. Significant delay (for 50--90 min) of the development of paradoxical sleep was observed which is considered as a manifestation of inhibition of further development of sleep mechanisms due to the effect of neuropeptide. The data obtained indicate that natural sleep is not identical to that induced by the neuropeptide.

Animals↗
PubMedDate not supplied

[Central action of a new cholinesterase reactivator, diethyxime].

In anesthetized cats, whose peripheral muscarinic-cholinorecptors are blocked by m-cholinolytics (benzilyl choline) failing to penetrate into the brain, the cholinesterases reactivator diethyxime debars the centrally caused fall of the arterial pressure produced by armine, an inhibitor of cholinesterases readily gaining access into the brain. Diethyxime is also capable of abolishing the depression of the phrenic nerve action potentials produced by armine. Dipyroxime-a quaternary diethyxime analogue and also a quaternary cholinesterase reactivator fails to produce such an effect.

Action Potentials↗