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Biomedical subjects

I Börner

Publications and source records attributed to I Börner.

7 recordsLinked to original sources
PubMed2000

Prevalence of obsessive-compulsive disorder in schizophrenia and significance of motor symptoms.

To investigate the differences between schizophrenic subjects with and without obsessive-compulsive disorder (OCD), the authors systematically assessed 76 schizophrenic subjects for OCD. Subjects with and without OCD were then compared with regard to motor symptoms, including catatonia, and several measures of psychopathology. Treatment strategies were evaluated retrospectively. The 12 subjects with OCD (15.8%) had more motor symptoms, including catatonia, than non-OCD schizophrenic subjects. Some differences were found with regard to psychopathological symptoms. Treatment strategies also differed in the two groups. The high prevalence of motor symptoms in these subjects supports the hypothesis of a basal ganglia-frontal lobe connection linking OCD with schizophrenia.

Adult↗
PubMed1997

[Neuroleptic-induced supersensitivity].

Psychopharmacological agents may cause changes in receptor sensitivity. Long-term treatment with high doses of neuroleptics has been shown to lead to supersensitivity of postsynaptic dopamine and noradrenaline receptors. Receptor supersensitivity is seen more frequently with neuroleptics known to have a high receptor affinity. The mechanism by which psychoses of the supersensitivity type work is presented and is illustrated by two case reports. Possible pathophysiological mechanisms for the emergence of these psychoses and implications for the treatment of patients suffering from them are discussed.

Antipsychotic Agents↗
PubMed1983

[Schizophrenia and B-lymphocyte alteration--a hypothesis].

We studied the immunglobulin synthesis of peripheral blood lymphocytes of healthy blood donors and of patients suffering from acute schizophrenia and endogenous depression. The detection of cytoplasmic immunglobulins was performed by immunofluorescence. The schizophrenic patients showed an increased immunglobulin synthesis without cultivation of lymphocytes, after cultivation for 7 days and after pokeweed mitogen stimulation. This activation of B cells could be the result of disturbances in the prostaglandin formation and activation.

Antibody Formation↗
PubMedDate not supplied

The catatonia rating scale I--development, reliability, and use.

The study objective is to present reliability data on the Catatonia Rating Scale (CRS). The CRS is a 21-item clinician-administered rating scale. Items are individually defined and are scored from 0 (absent) to 4 (severe). A definition for each degree of severity is provided for each item. The diagnostic threshold for catatonia is 4 symptoms rated at least 2 (moderate). The CRS requires, at most, 45 minutes to administer. Reliability data were evaluated in a sample of 120 inpatients, 71 of whom were catatonic. Ratings were performed by 4 pairs of raters. Interrater reliability was high (Pearson correlation coefficient = .91 to .99, intraclass correlation coefficient = .94 to .99). Internal consistency was very good (Cronbach's alpha = .8890). Analysis of individual items showed that all were frequently endorsed and occurred across a wide range of severity. The CRS is a reliable rating scale for the diagnosis of catatonia. Advantages of the scale, areas of use, and clinical implications are discussed.

Adult↗