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Biomedical subjects

I Baba

Publications and source records attributed to I Baba.

At least 19 recordsLinked to original sources
PubMed1991

Characterization of platelet aggregation induced by the human melanoma cell line HMV-I: roles of heparin, plasma adhesive proteins, and tumor cell membrane proteins.

We investigated the in vitro mechanism of platelet aggregation induced by HMV-I human melanoma cells. HMV-I cells, in the absence of exogenous plasma proteins, induced platelet aggregation, followed by the release reaction. Heparin at an anticoagulant concentration had no effect on the aggregation. Calcium ion was essential for this tumor cell-platelet interaction and could not be replaced by magnesium. Among the adhesive proteins containing RGD sequences that have been reported to enhance experimental metastasis, fibrinogen and thrombospondin significantly enhanced the aggregation induced by HMV-I cells, fibronectin and von Willebrand factor inhibited it, and vitronectin had no effect. To identify the platelet-aggregating factor(s) of the tumor cells, we have developed a monoclonal antibody against HMV-I cells that can inhibit HMV-I cell-induced platelet aggregation. Immunoprecipitation analysis revealed that this antibody recognized an Mr 71,000 membrane protein. These results suggest that the association between the tumor cells and platelets is mediated by the Mr 71,000 membrane protein recognized by this monoclonal antibody.

Antibodies, Monoclonal↗
PubMed1990

[A well differentiated fibrosarcoma arising in left neck region].

The frequency of a fibrosarcoma, based on current criteria, is less than 10% of soft tissue sarcomas. It is most common in the region of extremities and the trunk and relatively rare in the head and neck region. Therefore, of interest is a case of a well differentiated fibrosarcoma arising in left neck region of a 69-year-old woman that is reported. The excised tumor consisted of a firm, partially lobulated mass with a fibrous capsule that measured 8 cm at its greatest diameter. Histologically, the tumor tissue was rather uniform and often had a fasciculated growth pattern consisting of spindle shaped cells and interwoven collagenous fiber in a parallel fashion. To achieve a diagnosis, it was necessary to differentiate this type of fibrosarcoma from aggressive fibromatosis and myogenic tumor (leiomyoma or leiomyosarcoma).

Aged↗
PubMed1980

H-reflex of the upper extremities in cervical myelopathy.

A study was made of the H-reflex in the upper extremities to express objectively the degree of spastic paralysis in cases of cervical myelopathy. This reflex cannot normally be elicited in healthy persons. The H-reflex was elicited in 63 out of 80 patients with advanced symptoms of cervical myelopathy and was most frequently recorded from the median nerve. The H/M amplitude ratio is used to express the degree of spastic paralysis, the higher the ratio the more severe the dysfunction. The longer the clinical history the greater the tendency for the H-type of reflex to change to the HF-type and the higher the H/M amplitude ratio. The decrease rate of the pre- and post-operative H-reflex was high amongst soft disc cases whilst that in spondylosis and ossification of the posterior longitudinal ligament was low compared to the improvement in symptoms. It is concluded that the H-reflex in the upper extremities is a good method of expressing the degree of spastic paralysis in cervical myelopathy.

Aged↗
PubMed1975

[Studies on the relationship between dental plaque and the hard tissues of healthy and diseased teeth].

1. Dental plaques were detected in all the teeth under investigation, with the exception of impacted teeth. 2. The appearance of the plaques is regular. They occur chiefly in certain zones of the tooth crown and in retention areas. The film thickness ranges from 10 to 60 mum. 3. No alterations of the structure or of the primary texture of the hard tissues were observed on healthy and periodontally diseased teeth. The plaques infiltrate but slightly into the surface. 4. Carious teeth have a different appearance. The plaques infiltrate more or less deeply. They even penetrate into the macroscopically free zones of the enamel as well as of the dentine. The infiltrate is diffuse, especially in regions where the relationship between mineral and organic constituents is distrubed.

Dental Caries↗