Severe cutaneous toxicity following treatment with gefitinib (ZD1839).
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Biomedical subjects
Publications and source records attributed to I Belinchón.
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Polycythemia vera is classified with myelogenous leukaemia, agnogenic myeloid metaplasia and primary thrombocythemia as a myeloproliferative syndrome. Cutaneous symptoms have been reported with polycythemia vera, including facial plethora, aquagenic pruritus, urticaria, purpura, Sweet's syndrome and pyoderma gangrenosum. However, polycythemia vera associated with systemic sarcoidosis has been rarely reported. An unusual case of polycythemia vera associated with cutaneous sarcoidosis is described.
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The first two patients with skin infections in the perineal area due to Staphylococcus lugdunensis are described. One had an abscess of the Bartholin gland, and the other presented with several cutaneous abscesses in the pubic area, which had a prolonged and recurrent clinical course despite appropriate antibiotic treatment. This report emphasizes the pathogenic role of Staphylococcus lugdunensis and the importance of identifying coagulase-negative staphylococci to species level in some instances.
A case of a sebaceous gland hyperplasia confined to the mammary areolae is reported. Review of the literature documented only two more similar cases in this striking location. We comment on the cases and their possible origin.
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BACKGROUND: Dermal melanocytosis is characterized by the presence of melanocytes in the dermis. There are several morphologic forms, such as the blue nevus, the mongolian spot, the nevus of Ota, and the nevus of Ito. In this article, we report an unusual case of dermal melanocytosis. OBSERVATIONS: A 28-year-old white woman was referred to us, as she had an extensive, speckled gray-blue pigmentation on the right aspect of her trunk that was in a segmental pattern. The lesion had been present at birth. Histologic and ultrastructural examinations revealed sparse, elongated dermal melanocytes. CONCLUSIONS: We comment on the differential diagnosis with classic recognized forms of dermal melanocytosis. We also review other isolated cases of unusual dermal melanocytosis. This is a distinct case, clinically different from previously reported cases in the literature; we propose the term "congenital segmental dermal melanocytosis" to name this case.
Two patients, a mother and son, with a conspicuous redundant unique scalp fold are reported. No underlying disorder was found. Light microscopy was unremarkable. An atypical familial form of cutis verticis gyrata is suggested.
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The concurrence of Reiter's syndrome and human immunodeficiency virus infection has recently been noted. In this report the evolution of Reiter's syndrome (arthritis, urethritis, and conjunctivitis) in a patient with a history of intravenous drug abuse and positive results of serologic tests for human immunodeficiency virus is described and the literature is reviewed.
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