Biomedical subjects
Publications and source records attributed to I Beloev.
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The changes in the basic hemdynamic indices and in the phase structure of the cardiac cycle in patients with acute infarction prior to and post treatment with beta-blockers (Obsidan and Trasicor) were studied. Manifested changes in the hemodynamics were established, namly: pulse rate and cardiac flow decrease, the total peripheral resistance grows; veloqcilty of blood flow is slowed down. The preparations used have a negative effect upon the phase structure of left ventricle as well. The authors underline that beta-blockers administration in acute myocardial infarction should be evaluated very carefully and in the presence of clinical signs for cardiac insufficiency, it should be carried out on the background of cardiotonic treatment.
Hospital lethality was studied in myocardial infarction which was 24.9 per cent for the period 1973--1976 with a decreasing tendency during the last two years. The study covers 134 deceased of myocardial infarction at an average age of 70,78, their pathologoanatomical findings in the coronary arteries and localization of the nectrotic zone. In 49,26 per cent the case was that of repeated myocardial infarction, thus raising the lethality in the first 24 hours after hospital admission with 70,9 dead up to the 7th day. The analysis of the lethality causes revealed that according to the relative share they were as follows: acute cardiovascular failure, cardiac rupture, acute rhythm and conductivity disturbances, pulmonary embolism, inflammatory lung diseases, etc. No correlation was found between arterial hypertension, cigarette smoking and diabetes mellitus and the leading lethality cause.
The authors observed 40 patients (7.79%) with the morbid sinus node syndrome among the treated 526 patients with acute myocardial infarction at the department of intensive care during the period 1973--1976. Thirty one were males and nine--females. The syndrome was manifested, in all patients followed up, during the first 14 days after the onsed of the coronary incidence. One case was with a lethal end. Ten patients (1.90%) were observed with the syndrome "transitory collapse of R-deflection" in the separate precordial leads. Half of them had a combination of both syndromes. The collapse of R-deflection was manifested between the 3rd and 14th day in all cases. The character and incidence of rhythm-conductivity disturbances accompanying both syndromes are discussed.
The authors studied in dynamics the concentration of uric acid in 84 patients in the acute stage of myocardial, in 28 patients with non-stable stenocardia. The average value of uricemia, in the first 1--2 days post infarction is 6.35 +/- 2.23 mg%, considerably higher than that in case of non-stable stenocardia--4.75 +/- 1.25 mg%. In all the patients with myocardial infarction, 34.04 per cent have uricemia over 6 mg% (upper limit of the norm). The hypouricemia was normalized by the 14--15 day after the onset of infarction--4.25 mg%. The highest values of uric acid (up to 13 mg%) were found in case of severely progressing infarctions. A parallelism was established between serum concentration of uric acid and the creatinine-phosphokinase level. The possible pathogenic mechanisms of hyperuricemia in the acute stage of myocardial infarction are discussed.
The alveolar-capillary gas metabolism was studied in 60 patients with acute myocardial infarction. Arterial hypoxemia and hypocapnia were observed in the majority of the patients. Those disturbances are more pronounced in the presence of cardiac insufficiency. The combination of shunt effect with the diminution of cardiac volume is admitted to be the possible pathogenetic mechanism for arterial hypoxemia. The first mechanism is associated with the disturbances of the systemic hemodynamics. Both types of hemodynamic disturbances are conditioned by the weakness of the left ventricle.
The basic hemodynamic indices: cardiac volume, volume of circulating plasma and blood, total peripheral vascular resistance and velolity of blood flow were studied in 60 patients with myocardial infarction, subacute stage in progress, prior to and post veloergometric loading. A decreased tolerance to physical loading was established: cardiac index--insignificantly increased, beat volume-decreased, volume of circulating plasma and blood--tendency to increase. The results show a dependence on the clinical development of the disease--the signs of a latent insufficiency being manifested in the cases with extensive localization of the infarction, transmural affection and with a formed aneurisma after a dosed loading.
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The authors present a case diagnosed while still living, as an annular thrombus in the left atrium with the presence of a "pure" mitral stenosis. At necropsy, two thrombi were found, one of them "traveling", situated very close to each other, providing conditions for a complete obstruction of the mitral opening and imitating the respective clinical picture.
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Explore the source record for details and available documents.