Biomedical subjects

I Beno

Publications and source records attributed to I Beno.

At least 37 records · Page 2Linked to original sources

PubMed1992

[The effect of body weight reduction on apolipoprotein levels in obese patients].

In 16 obese male patients lipid and apolipoprotein A-I and B in serum were assessed before and after weight reduction. The mean age of the subjects was 34.7 +/- 2.7 years, the mean body weight 124.4 +/- 4.0 kg and the mean BMI 39.1 +/- 1.5 kg/m2. After 10 weeks on a low-energy diet of 2500-6000 kJ/day a decline of body weight was observed on average by 14% of the initial value. The total triacylglycerolaemia declined by 46% (p less than 0.02). The total cholesterol level declined by 12% (ns), HDL-cholesterol by 7% (ns), LDL-cholesterol by 8% (ns). The apo A-I did not change during weight reduction, apo B declined by 13% (ns). The ratio of apo B to apo A-I declined by 12.5% (p less than 0.05). The presented results indicate that after weight reduction of obese patients by a low-energy diet the risk of atherosclerosis declines as the apo B/apo A-I ratio declines.

Adult↗

PubMed1992

[Obesity and osteoarthritic changes in the lower extremities].

The purpose of the radiologic examination carried out in 124 obese subjects was to determine degenerative changes on the coxae and knees and entesopathy on the calices in relation to the degree and duration of obesity and the age of the subjects examined. The direct correlation established between the degree of obesity and each of the three parameters studied was most marked with respect to the knees of obese women. In a considerable number of subjects, changes of the coxae were found to develop also at a relatively low overweight. The highest rate of pathological changes was recorded in obese subjects with overweight lasting several decades or even throughout life. In the younger age group pathologic changes were observed in 10-30% of subjects, whereas of those in the 6th decade of life up to 96% were affected. The findings clearly show a direct relationship between the degree and duration of obesity as well as the age of the subjects and the extent of pathologic changes on the skeleto-tendinous apparatus of the lower extremities. Overweight appears to be a potential etiological and definitely a contributing factor of osteoarthrosis of the lower extremities and particularly of the knee. (Tab. 3, Fig. 3, Ref. 10).

Adult↗

PubMed1991

[Pain and osteoarticular changes in obese persons].

Obesity was confirmed as a possible aetiological and certainly promoting factor in the development of osteoarthritis (OA). One of the first clinical symptoms of OA is pain which does not always correspond with the X-ray picture of the damaged joint. The authors examined 11,124 obese subjects where they investigated X-ray changes of the hip joints, knees and heels and selected clinical symptoms. They correlated them with the degree of obesity, the duration of obesity and the subjects age. They revealed a direct correlation between the development of OA and all the investigated parameters. An alarming finding was that arthritis changes developed in the hip joints also in half the subjects with minor overweight and in particular that in one third of the obese subjects in the second and third decade pathological changes of the joints are present without causing subjects complaints. During a prolonged reducing regime attention must be paid to the possible development of osteopenia which may be also the source of pain. Obese subjects suffer pain also from nodes of non-inflammatory proliferated subcutaneous adipose tissue, venous insufficiency and trophic skin changes.

Adult↗

PubMed1991

[Serum lipids in obese persons in a selected population in the Slovak Republic].

Serum lipid levels were determined in 287 obese subjects and the findings were compared with the mean values recorded in a representative series of the population of the Slovak Republic (n = 3433). Comparison of serum lipid values in age-matched groups from the two series showed the following results: significant increase of triacylglycerols in obese men aged 15-55 y, in obese women aged 15-35 y; significant increase of total cholesterol in obese men aged 26-55 y, in obese women aged 26-35 y; significant reduction of HDL cholesterol in obese men after 25 years of age and in obese women after 35 years of age. Obesity was found to increase significantly serum lipid levels, particularly in men with predominant central-abdominal type of obesity.

Adolescent↗

PubMed1990

[Obesity and hyperlipoproteinemia. I. Changes in lipid levels in obese persons].

The authors investigated changes in serum lipid levels in 115 obese men and 172 obese women. The body mass index (BMI) of the subjects was 29-50 kg/m2. The group was subdivided by sex and age as follows: 15-18 years, 19-25 years, 26-35 years, 36-55 years. It was revealed that with advancing age and increasing body weight the mean tiacylglycerol levels in men increased from 1.74 mmol/l to 4.40 mmol/l, in women from 1.37 mmol/l to 1.84 mmol/l. The mean levels of total serum cholesterol increased in men from 4.58 mmol/l to 6.82 mmol/l, in women from 5.09 mmol/l to 5.96 mmol/l. In the rise of serum cholesterol in men the LDL and VLDL fractions participated, in women mainly the LDL fraction. Conversely the HDL fraction declined in men from 1.60 mmol/l to 1.20 mmol/l, in women from 1.71 mmol/l to 1.26 mmol/l. The mean value of the atherogenic index in men increased from 2.88 to 5.68, in women from 2.99 to 4.73. The results indicate the adverse changes of serum lipid levels in obese subjects which appear in men already after the age of 25 years, in women 10-20 years later. The authors discuss the causes of hyperlipoproteinaemia and the risk of atherosclerosis in obesity.

Adolescent↗

PubMed1990

[Obesity and hyperlipoproteinemia. II. The effect of a low energy diet on lipid levels in the blood of obese persons].

In 287 obese men and women with BMI values of 29-50 kg/m2, divided by sex and age, the effect of a low-energy diet on triacylglycerol (TG), total cholesterol (TC) and HDL-cholesterol (HDL-C) serum levels was investigated. On a diet of 2500 kJ/day (4 weeks) and 4000-7000 kJ/day (6 weeks) the body weight declined by 10-11% from the initial value. There was a significant drop of TG in obese men above 25 years and in obese women above 35 years of age. The mean TC values did not change significantly after weight reduction. The mean HDL-C levels increased significantly after weight reduction, as compared with initial values in both sexes in the groups aged 26-35 years. In this group there was also an increase of the relative ratio of HDL-C in TC and the value of the atherogenic index declined. The authors draw attention to the fact that with regard to preserving normal blood lipid levels, in particular in obese men, it is necessary to reduce or normalize body weight in the course of the third decade.

Adolescent↗

PubMed1986