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Biomedical subjects

I Binderman

Publications and source records attributed to I Binderman.

80 records · Page 5Linked to original sources
PubMed1974

Formation of bone tissue in culture from isolated bone cells.

A system is described for the formation of bone tissue in culture from isolated rat bone cells. The isolated bone cells were obtained from embryonic rat calvarium and periosteum or from traumatized, lifted periosteum of young rats. The cells were cultured for a period of up to 8 wk, during which time the morphological, biochemical, and functional properties of the cultures were studied. Formation of bone tissue by these isolated bone cells was shown, in that the cells demonstrated osteoblastic morphology in light and electron microscopy, the collagen formed was similar to bone collagen, there was mineralization specific for bone, and the cells reacted to the hormone calcitonin by increased calcium ion uptake. Calcification of the fine structure of the cells and the matrix is described. Three stages in the calcification process were observed by electron microscopy. It is concluded that these bone cells growing in vitro are able to function in a way similar to such cells in vivo. This tissue culture system starting from isolated bone cells is therefore suitable for studies on the structure and function of bone.

Alkaline Phosphatase↗
PubMedDate not supplied

The dental status of children with chronic renal failure.

We evaluated the dental status of thirty children with chronic renal failure (CRF): 15 managed conservatively, 9 on dialysis replacement therapy and 6 after kidney transplant. Dental age was delayed, but to a lesser extent than bone age; this delay was most marked where CRF occurred before 7 years of age. Eruption age was only minimally delayed. Eighteen patients (60%) showed enamel defects, mainly hypoplasia, the location of which was related to the age at which major metabolic changes of uremia appeared. In 9 children (30%) there was intrinsic discoloration of the teeth--this was also related to the severity and duration of CRF. Compared to normal Israeli children our patients showed poor oral hygiene and gingival condition, but a significantly lower prevalence of caries. Seven patients (23%) showed mild radiologic changes in the jawbones (mainly loss of lamina dura), the severity of which was related to the severity and duration of CRF. None of the above findings could be related to specific metabolic disturbances.

Adolescent↗
PubMedDate not supplied

Mechanical properties of bone-implant interface: an in vitro comparison of the parameters at placement and at 3 months.

Four biomechanical parameters--peak force, vertical displacement, interface stiffness, and strain energy--were defined to evaluate bone-implant interface properties. These parameters were measured at placement and after 3 months of healing during push-in tests on commercially pure titanium implants placed in the mandibles of dogs in a one-phase nonsubmerged procedure. Comparison of the results showed that peak force, interface stiffness, and strain energy increased after 3 months of healing, but vertical displacement decreased. These findings suggest that the interface stiffness, which is considered a major factor for implant success, increases during 3 months of healing in dogs, which corresponds to a 4- to 6-month healing period in human mandibles.

Alveolar Process↗