The frequency of symptoms and signs in 52 patients with chronic Lyme borreliosis was analyzed in the study. The significantly higher frequency of: headache, myalgias, cranial neuritis, chronic dermatitis, ataxia and arrhythmia (p < 0.05) was found in the group of untreated (n = 31) in the early phase compared to the frequency of the same symptoms in the group that was treated (n = 21). The neuropathy of sensitive type was more frequently noticed in that group (p < 0.01). The treatment of patients with Lyme borreliosis in the early stage should be started as soon as possible and should be performed until the probable elimination of significant decrease of causative agents number in the tissues.

Adolescent↗

PubMedDate not supplied

[Tonsillo-pharyngeal form of tularemia].

Clinical, laboratory and serologic features of tonsillopharyngeal form of tularemia in 14 patients were analyzed in the study. The disease was ignored under the diagnosis of typical tonsillopharyngitis followed by cervical lymphadenopathy. Routine laboratory analyses results were non-specific and didn't reveal the disease etiology, while microagglutination test (MAT) of F. tularensis in the second week of disease was positive in 86% of patients. Skin tularin test was positive in all the tested patients during the first week of the disease. The best results in the treatment were achieved by administration of streptomycin and doxycycline. Well timed therapy prevented the lymph nodes colliquation, disease recurrence and infection generalization. The authors point out the significance of this clinical form of tularemia in the differential diagnosis of tonsillopharyngitis and cervical lymphodenopathy.

Antigens, Bacterial↗

PubMedDate not supplied

[Autoimmune hepatitis and autoimmune manifestations in patients with chronic viral hepatitis].

The study reviews pathogenesis of autoimmune hepatitis and role of hepatotropic viruses in this disease. For a long time it was not known for certain which antigen was autoantigen on the hepatocyte. The discovery of human asialo glycoprotein receptor as an autoantigen enabled distinguishing autoimmune hepatitis from other chronic active hepatitis of unknown etiology. Autoantibodies and other tissue antigens ensured differentiation of autoimmune hepatitis in regard to severity of clinical manifestations in patients of different age and sex. The paper deals with autoantibodies and their occurrence in virally induced chronic hepatitis and some other autoimmune manifestations.

Autoantibodies↗

PubMedDate not supplied

[Principles of treatment of Borrelia burgdorferi infection and Lyme borreliosis].

Explore the source record for details and available documents.

Humans↗

PubMedDate not supplied

The significance of immunoglobulins in the treatment of patients with sepsis and septic shock.

Inappropriate body response is, besides the infectious agent, responsible for the genesis of sepsis and septic shock. It is non-specific and in cascade of events it can hardly be controlled. The results of immunoglobulins administration compared to the disease course and outcome have been compared and analyzed in 135 patients with sepsis and septic shock. A hundred and four patients were treated for sepsis. Immunoglobulins were administered to 18, of whom 17 patients (94.55%) were cured, while one (5.55%) developed septic shock with lethal outcome. Out of the other 86 patients who did not receive immunoglobulins, 82 (95.35%) were cured, while in 4 (4.65%) patients the outcome was lethal. No difference was observed between studied groups. Among 31 patients with septic shock, 13 received immunoglobulins. Seven (53.85%) patients were cured, and 6 (46.15%) died. In relation to the favorable disease outcome the difference was observed (statistically non-significant) in the group that received immunoglobulins, compared to the group that did not (53.85% vs. 44.45%). The importance of immunoglobulins administration, in sepsis and septic shock should be emphasized.

Adolescent↗

PubMedDate not supplied

[Personal experience in the diagnosis and treatment of hepatic echinococcosis].

Human echinococcosis is endemic disease that occurs in some regions of Yugoslavia. It is caused by tapeworm Echinococcus granulosus, whose larva can develop cysts in liver and other organs. In the study were presented 119 patients with hepatic echinococcosis, 57 (47.9%) females of average age 41.4 years (9-80) and 62 (52.1%) males of average age 35.5 years (6.72). Primary echinococcosis was present in 75 (63%), and recurrent in 44 (37%) patients. Right lobe of liver was affected in 83 (69.7%), left in 17 (14.3%) and both lobes in 19 (16%) of cases. The complications of hepatic echinococcosis such as cyst infection, cholestasis, cyst rupture in biliary tract and liver fibrosis were observed in 20 (16.8%) patients. Indirect immunofluorescence antibody test was positive in 91 out of 119 (68.1%) patients, and hemagglutination inhibition test was positive in 56 out of 77 (72.7%) patients. Surgically were treated 57 (47.9%) patients, and 41 of them received antihelminithic drugs pre and/or postoperatively. Disease recurrence was observed in 4 (7%) patients. Percutaneous puncture and drainage of echinococcus cyst with simultaneous albendazole administration was performed in 12 (10%) patients. In three of them liver abscess was developed during drainage, and for that reason, two patients had to be surgically treated. Ten (83.3%) patients were completely cured. Medicamentous therapy as the only treatment was used in 31 (26.1%) patients, 9 patients received mebendazole, 19 received albendazole and 3 patients received praziquantel. The success was achieved in 10 (32.3%) patients. Out of the total number, 19 (16%) patients were not treated at all. Surgical removal of the cyst takes a leading place in the treatment of hepatic echinococcosis. However, in well-selected cases and in the patients with high surgical risk, antihelminithic therapy and percutaneous drainage of echinococcus cyst are of more significance.

Adolescent↗