PubMed Health⌕ Search

Biomedical subjects

I Boldur

Publications and source records attributed to I Boldur.

52 records · Page 3Linked to original sources
PubMed1985

Serum antibodies to Legionella agents in bronchial asthma.

The prevalence of seropositivity to Legionella species was studied in 184 children with bronchial asthma and 80 control children, age and sex matched, without respiratory tract infections. The sera were examined by indirect immunofluorescence with antigens of six Legionella species. The asthmatic children showed a significantly high percentage of seroreactions to L pneumophila compared with the control children. In the asthmatic children, no association was found between age, sex, onset of asthmatic symptoms, living conditions, corticosteroid treatment, or exposure to aerosols and seropositivity to Legionella. No relation could be found between the asthma severity score and the titre of serum antibodies to L pneumophila. None of the 32 sera with titres of 1:256 or higher were reactive for Legionella specific IgE antibodies. A high prevalence of antibodies to L pneumophila was found in children suffering bronchial asthma. Further studies are necessary to clarify the clinical relevance.

Adolescent↗
PubMed1985

Legionnaires' disease: new etiologic agents.

Two patients with pneumonitis due to legionellosis are described. The etiologic diagnosis was based on high titers of immunoglobulin (Ig)M class antibodies (1/2048 and 1/512) detected by indirect immunofluorescence. The etiologic agents were presumed to be Legionella bozemanii in one case and either L. bozemanii or L. longbeachae in the other. Both patients made an uneventful recovery. Infections with these organisms have not been described in Israel previously.

Aged↗
PubMed1984

A prevalence study of antibodies to Legionella spp. in geriatric institutions.

The prevalence of seropositivity to Legionella spp. was studied in inmates and staff members of two geriatric hospitals (Rahel and Sinai); attendants to a geriatric Day Club; and 26 old people with entirely independent households. The sera were examined by indirect immunofluorescence with antigens of six Legionella species (L. pneumophila, L. longbeachae, L. micdadei, L. gormanii, L. dumoffii and L. bozemanii). A titre of greater than or equal to 256 to at least one antigen was obtained in 30.5% of patients and 35.7% of staff members from Rahel; 12.1% of patients and 17.2% of staff members from Sinai; 9.1% of attendants to the Day Club; and none of 26 old people with their own households. All the positive patients from Rahel reacted with L. pneumophila, but only four of seven of the positive patients from Sinai did so; none of the seropositive subjects from the Day Club reacted with this agent. The results indicate intramural exposure to agents of legionellosis, at least for the Rahel Hospital.

Aged↗
PubMed1984

Septicemia due to Corynebacterium haemolyticum.

A 65-year-old man in generally good health presented with symptoms of sepsis and mental confusion. Corynebacterium haemolyticum was isolated from three blood cultures, and a significant increase in the titer of immunofluorescent antibodies to the infecting organism was observed. Antigen of C. haemolyticum was demonstrated by double immunodiffusion in samples of cerebrospinal fluid and urine. The patient recovered after i.v. administration of 20 Mu/day penicillin. This is, to the best of our knowledge, the third reported human infection with C. haemolyticum with involvement of the central nervous system.

Aged↗
PubMed1982

Legionnaires' disease: a case acquired in Israel.

What is probably the first case of presumably nosocomial Legionnaires' Disease (LD) in Israel is described in a 56-yr-old man hospitalized for acute myocardial infarction. The patient developed bilateral pneumonia and hemorrhagic pleural effusion. The diagnosis of LD was confirmed by serological examinations that showed a significant increase and decrease in IgM- and IgG-type antibodies to Legionella pneumophila serogroups 1 and 3. The patient recovered on antibiotic treatment which included erythromycin.

Anti-Bacterial Agents↗
PubMed1982

Legionnaires' disease in Israel: a serological study of hemodialysis patients.

A serological survey was performed in three Israeli hospitals in order to evaluate the risk of nosocomial spread of the agent of Legionnaires' Disease or antigenically related organisms. Five out of 79 chronic hemodialysis patients had titers (1:512 to 1:2,048) of indirect immunofluorescence antibodies considered indicative of past infection. None of 44 healthy subjects, 37 ambulatory patients or 16 patients with acute gram-negative sepsis due to unrelated organisms showed a seroreaction of greater than or equal to 1:128.

Adult↗
PubMed1974

Antigen specific for bacteria resistant to tetracycline.

Antisera produced against envelope fractions of tetracycline-resistant Escherichia coli and supernatant fluid of disrupted cells of tetracycline-resistant Salmonella typhi were adsorbed with the corresponding fractions of susceptible cultures. With these sera, cross-reacting antigens were demonstrated in the following fractions obtained from tetracycline-resistant strains: envelopes of E. coli, supernatant fluid of S. typhi, and envelopes and supernatant fluid of Pseudomonas aeruginosa. These antigens were not demonstrable in the corresponding fractions from tetracycline-susceptible strains.

Animals↗
PubMedDate not supplied

Legionella longbeachae pneumonia in a patient splenectomized for hairy-cell leukemia.

A 63-year-old man was admitted to the respiratory intensive care unit for pneumonia. Fifteen years earlier, hairy cell leukemia had been diagnosed and the patient underwent splenectomy. A clinical suspicion of legionellosis, later confirmed by both serology and isolation of the microorganism, prompted initiation of high dose erythromycin intravenously. The patient steadily deteriorated and passed away eight days later. This is the first reported case of hairy cell leukemia in which the diagnosis of Legionella longbeachae sero-group 1 infection was based on both serology and isolation.

Drug Therapy, Combination↗
PubMedDate not supplied

Chlamydia pneumoniae community-acquired pneumonia: a review of 62 hospitalized adult patients.

In a prospective study, Chlamydia pneumoniae was identified as the etiological agent in 62 (17.9%) of 346 adult patients hospitalized over the course of one year for community-acquired pneumonia at the Soroka Medical Center in Beer-Sheva, Israel. The diagnosis of C. pneumoniae infection was based on serological testing of antibodies by the MIF technique. In 43 of these patients (69.4%), at least one other etiological agent, in addition to C. pneumoniae for community-acquired pneumonia was identified. Streptococcus pneumoniae was identified in 34 patients with C. pneumoniae (54.8%), as an additional causative factor in infection. Community-acquired pneumonia patients with C. pneumoniae were significantly older than non-C. pneumoniae patients (p = 0.03), had a higher APACHE II score on admission (p < 0.05), a higher rate of positive blood cultures (p = 0.02), and longer periods of hospitalization (p = 0.022). Seven patients with pure C. pneumoniae infection recovered, despite treatment which is not considered to be specific for C. pneumoniae. It was concluded that C. pneumoniae is a common etiological agent for community-acquired pneumonia in our region, particularly in the elderly, and is characterized by a high rate of concomitant infections with other pulmonary pathogens. No specific clinical or radiological pattern was discerned that could distinguish between C. pneumoniae community-acquired pneumonia and non-C. pneumoniae community-acquired pneumonia.

Adolescent↗
PubMedDate not supplied

Experimental septic arthritis in rabbits treated by a combination of antibiotic and steroid drugs.

OBJECTIVES: Intraarticular steroid injection is traditionally contraindicated during acute septic arthritis. However, there is abundant evidence which proves that the damage to the joint is not only due to the direct effect of bacteria, but also to the local protective mechanisms evoked by the organism. There is, therefore, theoretical justification for a combined therapy of systemic antibiotics and intraarticular corticostertoids in septic arthritis. METHODS: Experimental arthritis was induced by the intraarticular injection of Staphylococcus epidermidis in rabbits. The experimental scheme included three groups of animals: animals that were infected but not treated (group 1); animals treated with systemic antibiotics (group 2); and animals treated with systemic antibiotics and intraarticular steroids (group 3). Nine days later the animals were sacrificed and joint histopathological-histochemical indices were calculated. RESULTS: Animals from groups 2 and 3 had a smaller pannus, reduced proteoglycan loss, no loss of cartilage height and diminished synovial inflammation in comparison to the animals from group 1. The animals from groups 2 and 3 were identical in terms of cartilage cellularity, surface erosion, chondrocyte cloning, pannus formation and proteoglycan loss. Synovial inflammation appeared to be less pronounced in group 3 animals when compared to animals of group 2. CONCLUSION: Concomitant antibiotic-steroid treatment of septic arthritis seems to be harmless in this experimental setting.

Animals↗