Treatment of hereditary trembling chin with botulinum toxin.
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Biomedical subjects
Publications and source records attributed to I Bora.
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OBJECTIVE: To investigate the overall effect of repeated ultrasound treatment in carpal tunnel syndrome (CTS). DESIGN: Patient-blinded, placebo-controlled, before-after treatment trial. SETTING: University hospital PM&R department outpatient clinic and neurology department electromyography laboratory. PATIENTS: Eighteen women with diagnosis of CTS in 30 hands. INTERVENTIONS: Three groups, each with 10 cases of CTS, were randomly established. Continuous ultrasound therapy, with intensities of 1.5W/cm2 (group A), 0.8W/cm2 (group B), and 0.0W/cm2 (group C), was applied to palmar carpal tunnel area for 5 minutes, 5 days a week, for 2 weeks. OUTCOME MEASURES: Patients were evaluated clinically and electrophysiologically before and after the treatment. RESULTS: At the end of treatment, statistically significant improvement was obtained in clinical parameters in all groups: pain (p < .05), pain/paresthesia at night/day (p < .05), and frequency of awakening at night (p < .05). Although there was no statistically significant before-after difference in electrophysiologic studies, slightly decreased motor nerve conduction velocity and increased motor distal latency were noted in groups A and B, but not in group C. CONCLUSION: Ultrasound therapy in CTS was comparable to placebo ultrasound in providing symptomatic relief, and the probability of a negative effect on motor nerve conduction needs to be considered.
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The aim of this study was to look for regional cerebral blood flow (rCBF) abnormalities in patients with a recent diagnosis of pseudotumour cerebri (PTC) and to compare 99Tcm-hexamethylpropylene amine oxime (99Tcm-HMPAO) cerebral single photon emission tomographic (SPET) findings with those of X-ray computed tomography (CT) and magnetic resonance imaging (MRI). Seventeen consecutive patients aged 14-50 years (mean = 29 years) without previous drug treatment for PTC underwent 99Tcm-HMPAO SPET, cranial CT and MRI studies. No patient had evidence of intracranial mass lesions on the CT or MRI scans. Qualitative analysis of the 99Tcm-HMPAO SPET studies revealed impaired rCBF in nine (53%) patients. The CT and MRI studies revealed an empty sella in two patients, dural sinus thrombosis in one and a slit ventricle in another. Eight of the 13 patients with normal CT and MRI results had rCBF abnormalities. In contrast, three patients with CT and MRI abnormalities had a normal 99Tcm-HMPAO scan. Our results suggest that patients with PTC have functional abnormalities that are revealed by 99Tcm-HMPAO brain SPET.
Paraneoplastic syndrome refers to a group of disorders caused by or associated with cancers that are not direct effects of the primary tumor mass or a metastasis to the involved organs. Neurologically, the phrase describes a group of disorders that are diagnosed with increasing frequency in cancer patients. In this study, we investigated 36 patients with malignant diseases and various neurological paraneoplastic syndromes. Lung cancer is the most frequent malignancy associated with neurological paraneoplastic syndromes, and polyneuropathy is the most important manifestation among them.
The likelihood of seizure recurrence after a first unprovoked seizure has profound social, vocational and emotional implications for the patients. Recurrence rates have varied between 27% and 71% in various studies, and the management of patients with a single unprovoked seizure is a controversial topic. In this prospective study we investigated the influence of age, sex, family history, EEG patterns, and anticonvulsant drug (ACD) therapy on seizure recurrence after a first unprovoked tonic-clonic seizure in adults. For this purpose, between October 1988 and January 1991, we studied adult patients who had experienced their after unprovoked tonic-clonic seizure within last 2 months before neurological consultation, and followed them until June 1993. There were 147 patients who met the criteria for inclusion. Overall cumulative recurrence rates were 31.8% by 6 months, 41.3% by 1 year, 44.1% by 2 years, 42.2% by 3 years, and 45.2% by 4 years. Among the risk factors that were evaluated, the time of the day at which the initial seizure occurred was associated significantly (P < 0.05) with seizure recurrence. In our series, 62 patients received ACD and 85 did not. We did not find a significant difference in recurrence rate with regard to ACD therapy. Our results are comparable with those of studies reported previously and suggest that the majority of recurrences after a first unprovoked seizure were seen in the first year (in our series 89% of all recurrences). In our study there was no significant predictor of seizure recurrence, except the time of day at which the initial seizure occurred.
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