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Biomedical subjects

I Borg

Publications and source records attributed to I Borg.

At least 37 records · Page 2Linked to original sources
PubMed1984

Immunological aspects of humidifier fever.

An epidemiological investigation was made of eight employees working in a defined section of an office building who complained of febrile reactions accompanied by respiratory tract symptoms and fatigue. Culture of the water from the humidifier for their section yielded strains of Pseudomonas acidovorans and an unidentified Pseudomonas species. In vitro studies showed that these strains activated the alternative pathway of the complement system in Mg-EGTA supplemented serum, as evidenced by properdin depletion and conversion of C3-proactivator (Factor B) and C3. Whereas the employees with symptoms had significantly reduced properdin values during the symptomatic phase, a slight C3 conversion and antibodies to Pseudomonas spp., staff working in another part of the building with a different ventilation system did not. It was concluded that staff with humidifier fever symptoms had been exposed to Pseudomonas spp. through the faulty ventilation system, and their symptoms were most likely a result of complement activation.

Adult↗
PubMed1979

[A procedure for analyzing metric asymmetric proximity matrices (author's transl)].

A method is discussed and illustrated which yields a geometric representation of asymmetric proximity matrices. Assuming the observations are metric the data matrix is uniquely decomposed into a symmetric and a skew-symmetric matrix-valued component. The former entails a spatial configuration vis some MDS technique; the formation contained in the latter can then be integrated into this space in various ways.

Mathematics↗
PubMed1977

Efficacy and tolerance of Flunixin (SCH 14714) in the treatment of postoperative pain, with observations on the methodology of postoperative pain studies.

A new anti-inflammatory, antipyretic and analgesic drug 2(2'-methyl-3'-trifluoromethylanilino)-nicotinic acid (Flunixin, Sch 14714) was compared with aspirin and a placebo in a double-blind study of pain after four different types of operation. Sch 14714 proved to be superior to the two other drugs after herniorraphy and venous surgery of the leg. The frequency of adverse effects after this drug was, at most. 1.2% which did not differ from the side-effect rates of aspirin or placebo. The second and third days after operation yielded a very high rate of optimal pain relief scores resulting in poor discrimination. Thus cross-over studies seem to be superfluous in the study of pain-relieving drugs in the period following surgery. The patients' rather low demand of analgesic drugs indicated that more stringent enrollment criteria should be adhered to. It was also shown that radical venous surgery constituted a good model for pain studies.

Aniline Compounds↗
PubMed1975

The insulin test: negative and positive tests versus numerical values.

The result of the insulin test is commonly expressed as negative or positive according to different criteria. In 42 male duodenal ulcer patients subjected to selective vagotomy and pyloroplasty (SV + PP), negative and positive tests according to different criteria were compared with respect to the acid response to insulin and 2-deoxy-D-glucose (2DG), and to the percentage reduction of the response to insulin by SV + PP. The mean response to insulin and 2DG was smaller, and the mean reduction greater in negative than in positive tests according to any criterion. There was, however, a considerable over-lapping of the responses, or reductions, or both, between negative and positive tests. In tests negative to 4 or more criteria, insulin and 2 DG stimulated secretion by less than 0.50 mEq/30 min, but the reduction varied from 60 to 100 per cent. Accordingly, in individual patients the terms negative and positive test to most single criteria give no information about the acid response after the vagotomy nor about the effect of the vagotomy, unless the test is negative to 4 or more criteria. It is suggested that the result of the insulin or 2DG test should be reported in numerical values as basal and stimulated acid output and concentration instead of stating that the test is negative or positive.

Adult↗