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Biomedical subjects

I Boxen

Publications and source records attributed to I Boxen.

29 records · Page 2Linked to original sources
PubMed1990

Lymphoscintigraphy for cystic hygroma.

We present the case of an infant with a cystic hygroma investigated by lymphoscintigraphy. The source of lymph flowing into the hygroma was identified as were some ectatic lymphatics feeding it. Lymph flow was very rapid. The implications for therapy are discussed. Lymphoscintigraphy can assess many aspects of lymph flow not accessible by other means.

Antimony↗
PubMed1989

Endothelial hypoxia induction of atherosclerosis: an explanation of patency rates for internal mammary artery and other coronary artery bypass grafts.

The major etiological factors of atherosclerosis are reviewed and the case strengthened for endothelial hypoxia being the major initiator. Hypoxia is also shown to be the major cause of coronary artery bypass graft occlusions. The pathophysiological differences between pedicle and free arterial grafts and venous grafts are discussed. Arguments are presented to explain why pedicle internal mammary artery grafts have longer lasting a patency then saphenous vein grafts. It is proposed that free grafts using other systemic arteries should also give very acceptable results and may, in certain circumstances, be desirable over pedicle internal mammary artery grafts. The differences between single, Y and sequential grafts are also discussed to explain differences in patency rates.

Arteriosclerosis↗
PubMed1988

Comparison of the iodogen and the microelectrochemical techniques for the radioiodination of monoclonal antibody 140.240.

The Iodogen technique was compared with the microelectrochemical technique for the radioiodination of submilligram quantities of monoclonal antibody 140.240. The titre of the antibody against cultured melanoma cells was decreased five-fold after iodination with 0.80-0.85 atoms of iodine per molecule of antibody with both techniques. The Iodogen technique resulted in 82.1% incorporation of iodine into the antibody, somewhat higher than the 78.0% obtained with the microchemical technique (P = 0.10). Therefore, the Iodogen technique is the preferred method based on efficiency and convenience.

Antibodies, Monoclonal↗
PubMed1985

Mechanisms of atherogenesis: endothelial hypoxia proposed as the major initiator.

The major atherosclerosis risk factors hypertension, diabetes, hyperlipidemia and cigarette smoking are examined along with blood vessel anatomy, hemodynamics, histopathology and known experimental results. A common factor of blood vessel hypoxia, specifically endothelial and intimal hypoxia, is shown to exist. Arguments are presented suggesting endothelial hypoxia as the commonest initiating event for atherosclerosis. Cholesterol appears to be a secondary and opportunistic villain. Explanations are given for the lack of increased atherosclerosis risk in familial lipoprotein lipase deficiency (type I hyperlipoproteinemia) and for the increased incidence and severity of atherosclerosis in the human abdominal aorta in comparison with the thoracic aorta. It is suggested that effective prevention of atherosclerosis can be accomplished by lowering blood pressure and blood glucose, among others, even though these may be within acceptable normal limits. Suggestions are given for experiments to test the hypothesis of hypoxia being the major initiating factor in atherosclerosis.

Arteries↗
PubMed1985

Inadvertent lymphoscintigraphy?

Several examples of what is believed to be lymph node uptake of the bone imaging agent Tc-99m imidodiphosphate (Tc-99m IDP) are presented. This agent may prove to be useful for lymphoscintigraphy.

Adult↗
PubMed1982

Charcoal as a phase separating agent in ligand assays: mechanism of action and the effect of dextran and various proteins on the adsorption of of small molecules.

In ligand assays, charcoal mixed with dextran is sometimes used to separate free from bound ligand. This is done with the view that dextran "coats" the charcoal and produces a sieve effect on its surface. To further elucidate the mechanism of differential adsorption of small molecules to charcoal, studies were made on the interaction between a number of commonly measured ligands and charcoal, either unmixed or mixed with dextran, albumin, immunoglobulin (IgG) or insulin. "Coating" with dextran was shown not to have any effect on subsequent adsorption of the various ligands. However, coating charcoal with albumin, IgG or insulin did have an effect and even augmented subsequent adsorption of small molecules under certain conditions. It is concluded that the use of "dextran coating" of charcoal to give a sieve effect for the separation of small molecules from large ones is unnecessary and has no basis in fact. This is not the case for coating charcoal with proteins.

Animals↗
PubMed1981

Gallium in the sac.

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Gallium Radioisotopes↗