In 1984 the General Practitioner Hypertension Study Group undertook a rescreening of their patient population, looking for patients who still had untreated mild to moderate essential hypertension. Suitable patients were entered into a clinical trial comparing the safety and efficacy of nicardipine (a calcium antagonist) and amiloride + hydrochlorothiazide (HCTZ) (moduretic). The study included one year of long-term follow-up. Both drugs significantly lowered BP in both the short and long term. Numbers and percentages of patients from each group reporting adverse experiences were similar in the short term, but in the long term the frequency of adverse event reporting was much lower with nicardipine treatment than with amiloride + HCTZ treatment (2/10 versus 9/17). Treatment with amiloride + HCTZ led to elevations in serum levels of cholesterol, uric acid and urea, which were maintained at one year, whilst no abnormalities in blood biochemistry were seen in patients treated with nicardipine. In conclusion we have found that nicardipine compares very favourably with amiloride + HCTZ in the treatment of mild to moderate hypertensive patients.

Adolescent↗

PubMed1983

Induction of morphologically abnormal sperm in rats exposed to O-Xylene.

An analysis of sperm abnormalities can be used as a rapid method to determine the mutagenic potential of chemical agents as well as the toxic potential of chemicals on the whole animal. O-Xylene was investigated for its potential mutagenicity by the sperm abnormality assay. Sprague Dawley rats 10-16 weeks old were injected intraperitoneally (ip) with 0.5 and 1.5 ml/kg body weight of o-xylene in corn oil. Five weeks after treatment, animals were sacrificed and sperm examined for morphological abnormalities. Several morphologically abnormal sperm types were observed; among these were those with amorphous heads, and banana-like heads. Animals housed at room temperatures of 20-24 degrees C showed no significant increase in abnormal sperm over the control. Rats housed at temperatures between 24 and 30 degrees C after ip injection with 0.5 ml/kg o-xylene showed a significant increase in abnormal sperm.

Animals↗

PubMed1980

Outcome expectation ratings as predictors of success in weight reduction.

Identification of obese persons likely to benefit from weight reduction programs presents considerable difficulty. Neither biological (e.g., adipose cellularity) nor psychological (e.g., MMPI profiles) measures thus far have been shown to differentiate reliably between those who do and those who do not lose weight in such programs. Fifteen obese persons about to enter a group program intended to produce "conditioned satiety" were asked to estimate the number of pounds that they expected to lose. Their outcome expectation was found to correlate significantly with weight loss recorded 7 weeks later. However, the magnitude of expected weight loss exceeded the actual amount of weight lost.

Adult↗

PubMed1977

Point of order! How to streamline meetings.

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Governing Board↗