Biomedical subjects

I Brajkovich

Publications and source records attributed to I Brajkovich.

3 recordsLinked to original sources

PubMed1986

Effect of hypercapnia on fluid filtration rate during forward and reverse perfusion of isolated rabbit lungs.

Fluid filtration rate (FFR) was measured under predominantly zone-three conditions in isolated rabbit lung perfused at constant flow. During forward and reverse perfusion, alveolar hypercapnia significantly increased mean pulmonary artery pressure but did not change FFR. We conclude that the pulmonary vasoconstriction induced by alveolar hypercapnia occurs on both arterial and venular sides of the pulmonary circulation.

Animals↗

PubMed1985

Positive end-expiratory pressure may decrease arterial oxygen tension in the presence of a collapsed lung region.

The effect of positive end-expiratory pressure (PEEP) on PaO2 during collapse of a single pulmonary lobe was investigated in seven dogs. Increasing PEEP to the ventilated region of lung increased the proportion of cardiac output flowing to the collapsed lobe and decreased PaO2 and pH. PaCO2 increased at the onset of lobar collapse but was not significantly altered by changes in PEEP. In impaired lungs, the benefits of PEEP may be offset by an increase in blood flow to the unventilated region and hence lead to a decrease in PaO2.

Analysis of Variance↗

PubMed1985

Effect of plasma colloid osmotic pressure on fluid filtration rate in isolated rabbit lungs.

The relationship between fluid filtration rate (FFR) and plasma colloid osmotic pressure (COP) was studied in isolated rabbit lungs perfused at constant flow. A 50% to 60% decrease in COP increased FFR more when left atrial pressure (LAP) was 12.8 to 15 mm Hg than when it was 7.5 to 9 mm Hg. When LAP was zero, FFR did not increase until COP had been reduced from 18.8 to 7 mm Hg. The increase in FFR produced by step increases in LAP was eliminated by similar increases in COP.

Animals↗