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Biomedical subjects

I Carr

Publications and source records attributed to I Carr.

At least 73 records · Page 4Linked to original sources
PubMed1975

The ultrastructure of the abnormal reticulum cells in Hodgkin's disease.

The ultrastructure of tissues from 23 cases of Hodgkin's disease is described. The atypical neoplastic reticulum cell or Hodgkin cell has several features that suggest that it is of macrophage lineage. Rings of small lymphocytes are found round the neoplastic reticulum cell; less often macrophage processes are found closely related to it. The features may be those of a lymphoreticular reaction to the neoplastic reticulum cells. The fibrosis may also represent a host reaction.

Cell Nucleolus↗
PubMed1975

The fine structure of the reticulum cells in lymph-nodes from cyclophosphamide-treated thymectomised mice.

In mice depleted of lymphocytes by thymectomy and cyclophosphamide treatment the popliteal lymph nodes showed macrophages, fibroblasts, endothelial cells and a heterogeneous group of cells here described as reticulum cells. Some of these both within and outside the germinal centres had fine long processes, i.e., were dendritic, and some had deep cytoplasmic invagination. Interdigitating cells were not a feature of the nodes and there was little evidence of migration of cells through post-capillary venules.

Animals↗
PubMed1975

Cellular immunity to myelin basic protein in man and in animal model systems as measured by the macrophage migration inhibition test.

Lymphocytes from patients with neoplastic disease were tested for sensitization to encephalitogenic factor (EF) by the macrophage migration inhibition test. Sensitization to EF was demonstrated in 71% of patients with various forms of neoplastic disease. Sensitization to EF was also demonstrated for 31% of subjects with no evidence of neoplastic disease; these included patients with warts, chronic bronchitis and hernias. In contrast, healthy subjects showed no sensitization to myelin basic protein. These observations suggest that sensitization to EF may not be confined to patients with neoplastic disease. Lymphocytes from hamsters bearing a transplanted virus induced tumour were sensitized to EF prepared from both human and hamster brain. Sensitization was also seen in hamsters infected with influenza virus but not in animals with acute tubular necrosis produced by glycerol treatment. The development of an animal model system provides a method for the investigation of possible mechanisms of sensitization.

Animals↗