PubMed Health⌕ Search

Biomedical subjects

I Chambers

Publications and source records attributed to I Chambers.

38 records · Page 3Linked to original sources

Medical information from referral letters.

The letters of referral to the hospital with respect to 70 dental patients with medical problems relevant to dental treatment were studied for information about the medical history. The relevant medical history had been documented in fewer than 40% of the referrals. Referrals from medical practitioners more frequently contained relevant histories (57%) than did those from dental practitioners (34%). Some important problems, such as the tendency to bleed and the predisposition to infective endocarditis, were documented in most instances but other problems, such as a history of corticosteroid treatment or of respiratory disease, were often omitted. Dental practitioners should appreciate that their documentation of medical problems is not superfluous since it helps by providing another line of defense against error.

Adolescent↗

The structure of the mouse glutathione peroxidase gene: the selenocysteine in the active site is encoded by the 'termination' codon, TGA.

Glutathione peroxidase (GSHPx) is an important selenium-containing enzyme which protects cells from peroxide damage and also has a role in leukotriene formation. We report the identification of a genomic recombinant as encoding the entire mouse GSHPx gene. Surprisingly, the selenocysteine in the active site of the enzyme is encoded by TGA: this has been confirmed by primer extension/dideoxy sequencing experiments using reticulocyte mRNA. The same site of transcription initiation is used in three tissues in which the GSHPx mRNA is expressed at high levels (erythroblast, liver and kidney). Like some other regulated 'house-keeping' genes, the GSHPx gene has Sp1 binding site consensus sequences but no 'ATA' and 'CAAT' consensus sequences upstream of the transcription initiation site. Moreover, there is a cluster of two Sp1 binding site consensus sequences and two SV40 core enhancer sequences in the 3' region of the gene, close to the previously mapped position of a DNase I-hypersensitive site found only in tissues expressing the GSHPx mRNA at high levels.

Amino Acid Sequence↗