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Biomedical subjects

I Chiaramonte

Publications and source records attributed to I Chiaramonte.

At least 19 recordsLinked to original sources

Hemorrhagic unilateral moyamoya: report of one case.

A 29 year old woman presented with an intracerebral hemorrhage. Angiographic findings were consistent with unilateral moyamoya. The patient was managed non-surgically and discharged with the indication of periodical followup angiography. Moyamoya is a rare entity that must be considered in the differential diagnosis of ischemic or hemorrhagic cerebrovascular events. At present, the natural history of unilateral moyamoya is not well established in relation to the progression to a bilateral form and to rebleeding risk. Periodical follow-up angiography (conventional or MRI) seems a reasonable management strategy.

Adult↗

Cervical spinal epidural abscesses. A report on five cases.

The authors report a series of five cases of non tuberculous cervical spinal epidural abscesses. There were neither patients suffering from immunodeficiency syndromes nor drug addicts; all the patients were in their seventh decade; two patients were affected by diabetes mellitus refractory to medical treatment. Retropharyngeal abscess was the main etiological risk factor (two cases); Staphylococcus aureus was cultured in two cases. Gadolinium MRI was necessary for a preoperative diagnosis, planning surgical approach and postoperative prognosis. Surgical debridement was performed via an anterior approach in those cases where the collection was located lower than C4 and did not span more than three vertebral segments; posterior approach, via a laminectomy, was performed in a case of C1-C2 location of the lesion and in a case of involvement of the whole cervical spine. Surgical results were poor in those patients affected by diabetes mellitus, a lesion involving the high cervical segments (higher than C4) or a lesion spanning more than three levels. Medical treatment with MRI follow-up was not undertaken in any of the patients and we opted for surgical drainage in all the cases due to the possibility of a sudden neurological deterioration, caused both by spinal cord mechanical compression and vascular compromission.

Abscess↗

Spinal malignant melanotic schwannoma. Case report.

The authors report a rare case of spinal cord compression syndrome due to a malignant melanotic schwannoma. Pathogenesis, diagnostic difficulty and therapeutical problems are discussed. The authors conclude that such tumours should be surgically treated due to the possibility of a benign clinical behaviour even in those cases showing malignant histological features.

Adult↗

Cervical epidural abscess: serial MRI study.

Cervical epidural abscess (CEA) at first often goes unrecognized and it is to be suspected in patients suffering by spinal ache, root pain, neurological deficit and fever. Staphylococcus aureus is the most frequent etiologic agent. At present MRI is the study of choice for the diagnosis of CEA. We suggest a serial MRI study in close time in at first doubtful cases of CEA. When the responsible organism is not identified and there are also compressive signs of the spinal cord, the treatment of choice is surgical decompression followed by selective antibiotic therapy. The duration of antibiotic therapy may be established not only by clinical judgement, but also by serial MRI study, which gives direct information about disease evolution.

Abscess↗

Infected cerebral hemorrhage by ruptured infectious anterior communicating artery giant aneurysm in a patient with T cell acute lymphoblastic leukemia. Case report.

Although the majority of infectious (bacterial) intracranial aneurysms occur in patients with subacute bacterial endocarditis, septic cerebral embolization and infectious intracranial aneurysm formation can also occur in immunocompromised patients. We report the case of ruptured bacterial aneurysm occurring in a 19 years old man immunocompromised by vigorously treated acute lymphoblastic leukemia. This case confirms very poor prognosis for infectious aneurysms in immunocompromised patient reported in literature, suggesting that a high index of suspicion needs for early diagnosis and that a conservative approach (high dose antibiotic therapy with possible delayed surgery) should be preferred unless intracerebral hemorrhage or abscess with significant mass effect provides a clear indication for operative intervention.

Adult↗

Idiopathic middle cerebral artery occlusion in children: report on three cases.

Three cases of middle cerebral artery occlusion in children are reported. The origin of M1 was the site of occlusion in two cases, while occlusion 1 cm after the origin of M1 was found in the third. The possible etiological diagnosis was infectious arteritis in the first two cases, cranial trauma in the third. In no case were serious contralateral motor deficits detected in follow-up examinations. Follow-up digital subtraction angiography showed complete regression of arterial lesions in the second case. The authors conclude that middle cerebral artery occlusion may have a benign clinical course in children; surgical revascularization is indicated only in highly selected cases.

Arteritis↗

Distal posterior inferior cerebellar artery saccular and giant aneurysms: report of two new cases and a comprehensive review of the surgically-treated cases.

Aneurysms of the distal posterior inferior cerebellar artery are rare comprising less than 0.5 to 3% of all aneurysms. The authors report two cases of distal PICA aneurysms: a case of a ruptured saccular aneurysm arising on the tonsillomedullary segment of the PICA and a case of a giant aneurysm arising on junctional site of lateral-medullary and tonsillo-medullary segments. In the first case subarachnoid and intraventricular hemorrhage was diagnosed by CT and four vessel-angiography visualized the aneurysm which was clipped successfully. In the second case MRI was suggestive for posterior fossa giant aneurysm; four vessel angiography confirmed the suspicion, detected distal PICA origin of the giant aneurysm and disclosed the association with a middle cerebral artery saccular aneurysm. Because of lacking of a clippable neck and important perforating vessels to brainstem, the aneurysm was trapped and excised successfully. The literature is exhaustively reviewed. Discussion regarding to distal PICA aneurysm distribution (location, age, sex, multiplicity and associated vascular anomalies), pathophysiology, clinical presentation, neuroradiological findings, surgery and outcome is presented.

Adolescent↗

Craniofacial pain and incomplete oculomotor palsy associated with ipsilateral primitive trigeminal artery. Case report.

A case is reported of persistent primitive trigeminal artery associated with recurrent facial pain and noncomitant strabismus by partial ipsilateral oculomotor palsy. Transcranial Doppler disclosed indirectly persistent carotid-basilar anastomosis. CT and angiography allowed complete diagnosis excluding a posterior communicating artery aneurysm, a Tolosa-Hunt syndrome and an ophthalmoplegic migraine. Steroid therapy is recommended treatment. Surgery should be considered when symptoms are intractable to medical therapy.

Adult↗

Failed lumbar disk syndrome.

The Authors report 8 cases of Failed Lumbar Disk Syndrome (FLDS), on 210 patients operated for slipped disk. Risk factors and the concept that an abnormality involving either neurons in the substantia gelatinosa or internucial fibers in Lissauer's tract is responsible for pain in patients with FLDS are discussed. Since iatrogenic deafferentation pain response to almost all current forms of therapy is generally poor, the most rational approach remains prevention.

Back Pain↗

Intracerebral mass lesions in patients affected by AIDS.

"Toxoplasma gondii" cerebral abscess is a common opportunistic infection in patients affected by AIDS. Making a reliable diagnosis of acute cerebral toxoplasmosis is difficult in AIDS patients because of the lack of specificity of serological data and neuroradiological findings. Brain biopsy is the only procedure which enables a reliable diagnosis to be made a trial of specific medical therapy for toxoplasmosis in patients affected by AIDS and intracranial mass lesion can be advisable before performing brain biopsy. The authors report the cases of three patients affected by AIDS and cerebral toxoplasmosis. Tissue diagnosis was made in the first patient from autopsy material while a presumptive diagnosis was made in the other two cases since specific medical therapy resulted in a dramatic improvement of the neurological status. Despite the good possibilities in the treatment of this complication AIDS, however, carries a poor prognosis.

Acquired Immunodeficiency Syndrome↗

Neurocysticercosis treated with praziquantel. Long-term follow-up of a case.

The Authors report a case of neurocysticercosis treated with praziquantel and ventriculoperitoneal shunt. The patient presented, at CAT, multiple intracranial calcifications and cysts located in the cerebral parenchyma, ventricular system and subarachnoid cisterns. Praziquantel was orally administered at a daily dosage of 50 mg/kg. Two 15 day cycles of therapy were administered with an interval of one month between them. No significant side effects were observed during the treatment. Serial follow-up CAT scans demonstrated a gradual decrease in size and, finally, total disappearance of the cystic lesions. No neurological disfunction was observed at the last follow-up examination 4 years after treatment.

Brain Diseases↗

A case of thrombosed aneurysm of the vein of Galen associated with superior sagittal sinus thrombosis.

A case of thrombosed aneurysm of the vein of Galen associated with superior sagittal sinus thrombosis is reported. Clinical course was characterized by multiple intraparenchimatous hemorrhages and hydrocephalus. NMR showed dural sinuses thrombosis better than CT even though cerebral angiography was more effective for the diagnosis. Intracranial hypertension due to hydrocephalus was relieved with a ventriculoperitoneal shunt. The authors suggest that the abnormal hemodynamic patterns due to the drainage of the malformation into the vein of Galen and dural sinuses led to venous occlusion and multiple intracranial hemorrhages.

Cerebral Angiography↗

Craniocerebral gunshot wounds in civilians. Report on 40 cases.

The Authors report an analysis on 40 cases of craniocerebral gunshot wounds treated in a civil hospital over a 8-year period. The important role of CT for a correct diagnosis and treatment planning is stressed even though patients with a G.C.S. lower than 4 die regardless of their CT findings; subdural and intracerebral hematomas are not a serious complication unless patient's neurological status is poor; timing of surgical treatment plays a major role in order to avoid infection of the wound.

Adolescent↗