Adult New Zealand white does were intubated orally with single daily doses of 0, 5, or 10 mg of photomirex (8-monohydromirex) per kg body weight from the 6th through to the 18th day of gestation. Pregnancies were interrupted at term by cesarian section and fetuses removed and evaluated by following routine teratologic methods. Both maternal and fetal tissues were analyzed for residues of photomirex. None of the treated does showed any sign of toxicity. Except for a significant reduction in the mean fetal weight of the 10 mg/kg group all other parameters which evaluated fetal survival and fetal development were within the control range. Photomirex was found in all tissues examined. In the doe, the highest levels were found in fat followed by liver, kidney, spleen, heart, brain and blood. Photomirex was readily transferred across the placenta and accumulated in the fetus. However, in the fetus the highest levels were found in the heart, followed by liver, brain and blood. There were no teratogenic effects at the doses used in this study.

Animals↗

PubMed1978

Metabolism of nitrilotriacetic acid (NTA) in the mouse.

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Acetates↗

PubMedDate not supplied

Ninety-day toxicity of photomirex in the male rat.

Photomirex (8-monohydromirex) is a demonstrated environmental contaminant and was observed in previous short-term studies to produce lesions in the liver, thyroid and testes of male rats. The present study was undertaken to confirm those observations and to determine the effects after a longer period of exposure. Male rats were fed photomirex for 13 weeks at levels of 0.20, 1.0, 5.0, 25 and 125 ppm in the diet. Deaths were observed in animals receiving the highest dose. Decreased body weight gain and food intake were also observed in that group. Liver weights were increased at 5.0 ppm photomirex and higher. Photomirex caused changes in several biochemical parameters including serum sorbitol dehydrogenase and hepatic aniline hydroxylase activities. Dose-related histological abnormalities were observed in the thyroid and liver starting at the lowest dose level. These results confirm earlier findings and show that photomirex is a potent hepato- and thyrotoxin.

Aniline Hydroxylase↗

PubMedDate not supplied

Photomirex: synthesis and assessment of acute toxicity, tissue distribution, and mutagenicity.

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Animals↗

PubMedDate not supplied

The accumulation of mono-2-ethylhexylphthalate (MEHP) during storage of whole blood and plasma.

The accumulation of the plasticizer di-2-ethylhexylphthalate (DEHP) in blood and blood components has been of considerable concern for some time. We have followed the accumulation of DEHP and one of its major metabolities, mono-2-ethylhexylphthalate (MEHP) during storage of whole blood, platelet-rich plasma, platelet concentrates, and platelet-poor plasma for periods ranging from 72 hours to four weeks. Both phthalates showed a progressive increase in concentration with time. While the levels of DEHP were much greater than those of MEHP, there was nonetheless a significant and continual increase in MEHP in all preparations. The highest concentrations of both DEHP and MEHP were found in the platelet-poor plasma, indicating that platelets do not have a major role in the accumulation of the phthalates in blood. The accumulation of MEHP was shown to be a direct result of the metabolism of DEHP by plasma protein(s) rather than leaching from the blood bag.

Blood Platelets↗

PubMedDate not supplied

Metabolism and tissue distribution of mono-2-ethylhexyl phthalate in the rat.

The absorption, distribution and metabolic excretion of mono-2-ethylhexyl [7-14C]phthalate (MEHP) were studied in the rat. This compound was readily absorbed from the gastrointestinal tract. Radioactivity following intravenous administration of 14C-MEHP was rapidly distributed in all tissues, with the highest levels occurring in the liver, kidney, and urinary bladder. Excretion of radioactivity was rapid and approximately 80% of the dose was eliminated 24 hr after oral administration, 72% in the urine and 8% in feces. MEHP was extensively metabolized after oral administration, and the major urinary metabolites were identified as an alcohol, a ketone, and an acid resulting from the side-chain oxidation of MEHP. A trace of o-phthalic acid was also identified.

Animals↗

PubMedDate not supplied

The absorption, distribution and excretion of photomirex in the rat.

The absorption, distribution, and excretion of photomirex were investigated in the rat. Photomirex was absorbed slowly after oral administration, appeared in the blood at 1.5 hr, and reached the peak concentration 4 hr after dosing. Elimination from the blood was studied in rats receiving single intravenous doses; the semilog-arithmic decay curve was found to be triphasic. The highest concentrations were present in the rat, liver, and skin. Approximately 38--42% of the orally dosed photomirex was excreted in the feces in the first 3 days and 51--55% was eliminated in 28 days. Only trace amounts of photomirex were found in the urine (less than 0.09% of the total dose in 24 hr). Photomirex constituted about 95% of the total radioactivity found in the tissues and feces. No metabolite was detected in the radioactive material extracted from tissues or feces.

Animals↗