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Biomedical subjects

I Ciric

Publications and source records attributed to I Ciric.

36 records · Page 2Linked to original sources
PubMed1985

Pituitary tumors.

Great strides have been made in the understanding of anatomy, physiology, pathology, diagnosis, and treatment of pituitary adenomas. The single greatest credit should probably be given to the rapid advancement in surgical techniques that ushered in a new era of multispecialty interest in the pituitary and its disorders. The fate of patients with pituitary adenomas was thus greatly improved. Surgical treatment can offer a cure in a vast majority of patients. The morbidity and mortality following transsphenoidal surgery are low. In patients with certain hormonally active pituitary macroadenomas, multidisciplinary therapy including pre- and postoperative medical management with bromocriptine and postoperative radiation therapy have decreased the recurrence rate to a respectable 10 per cent.

Adenoma↗
PubMed1985

Lumbar spinal-lateral recess stenosis.

The syndrome of a lumbar spinal and lateral recess stenosis is characterized by pain and a variety of paresthetic symptoms occurring principally when the patient stands or walks. Sitting or lying down alleviate the symptoms promptly. The neurologic examination is characterized by a negative straight leg-raising test and a paucity of abnormal neurologic findings. The diagnosis is confirmed by a high-resolution CT scan. If conservative treatment fails, a myelogram is in order to establish a definitive diagnosis and assess the severity of neural compression prior to placing the indication for a surgical decompression of the stenotic spinal canal. The surgical procedure consists of a laminectomy and a partial facetectomy of the hypertrophied portion of the facet joint that compresses the adjacent lumbar nerve root from a dorsal direction. It is important to recognize all associated pathologic processes that must be dealt with accordingly at the same time in order to assure success of the operative procedure. The results of a surgical decompression for a lumbar spinal and lateral recess stenosis are excellent.

Cauda Equina↗
PubMed1983

Transsphenoidal microsurgery of pituitary macroadenomas with long-term follow-up results.

The authors have reported on 108 patients with pituitary macroadenomas (measuring 2 cm in at least one diameter) who underwent 117 transsphenoidal operations and five craniotomies, and were followed for periods ranging from 6 months to 14 years. Vision improved in 90% of the patients. Gross total tumor removal with no evidence of residual tumor tissue demonstrable on the postoperative computerized tomography scan was accomplished in 41% of cases. However, gross total tumor removal is not synonymous with complete tumor removal. Endocrine cure was possible in 25% of prolactin-secreting and 20% of growth hormone-secreting adenomas. The incidence of recurrence was 12%, with the majority occurring from 4 to 8 years postoperatively. Both the tumors with suprasellar extension of more than 2 cm and the hard fibrotic tumors had a higher recurrence rate. Postoperative administration of radiation therapy has been associated with a significantly lower recurrence rate than when this therapy was withheld. Transsphenoidal surgery of pituitary macroadenomas confined to the extra-arachnoid space is associated with a relatively small number of complications. The operative technique used in this series is described.

Adenoma↗
PubMed1981

Pituitary Cushing's syndrome and Nelson's syndrome: diagnostic criteria, surgical therapy, and results.

Eight patients with pituitary Cushing's syndrome and 2 with Nelson's syndrome were followed from one to ten years after removal of pituitary adenomas. A detailed assessment of the pituitary-adrenal axis was obtained in all patients when last seen, save the first, who had undergone a complete hypophysectomy ten years previously. Long-term observations have shown sustained endocrine cure in 7 of 8 patients with pituitary Cushing's syndrome. One patient with Nelson's syndrome was also cured. There was no operative morbidity or mortality. There were no instances of diabetes insipidus. The long-term results in this study indicate that patients with pituitary Cushing's syndrome have a better than 90% chance of being cured after transsphenoidal removal of the pituitary (micro) adenomas. Current diagnostic and therapeutic concepts in the management of pituitary Cushing's syndrome are discussed in detail.

Adrenocorticotropic Hormone↗
PubMed1981

Neuroradiological evaluation of lateral recess syndrome.

Fifty asymptomatic patients and 35 with surgically proved lateral recess syndrome (LRS) were studied retrospectively to determine the depth of the normal and abnormal lateral recess. Plain radiography, polytomography, CT, and myelography of the lumbosacral area were performed. The normal and abnormal ranges are presented and the role of the various radiographic procedures in the diagnosis of LRS is discussed.

Humans↗
PubMed1980

Spinal cord compression with paraplegia in myelofibrosis.

Paraplegia developed in a 70-year-old man with a 15-year history of polycythemia rubra vera and a two-year history of myelofibrosis, due to extensive epidural involvement by extramedullary hematopoiesis. Early diagnosis and aggressive therapy is essential if permanent paralysis is to be avoided.

Adolescent↗
PubMed1980

The lateral recess syndrome. A variant of spinal stenosis.

Sixteen patients with a surgically proven lateral recess stenosis were studied retrospectively. Lateral recess stenosis should be suspected in patients with disabling intermittent neurogenic claudications. The neurological examination is usually unremarkable. the diagnosis is assured when the lateral recess measures less than 2 mm in height. A lateral recess of 5 mm or more rules out the possibility of a lateral recess stenosis. Surgical decompression of the lateral recess requires removal of the horizontal portion of the superior articular facet.

Aged↗
PubMed1978

[Metastatic breast carcinoma in the pituitary gland (author's transl)].

Metastatic carcinoma was found in 9 pituitary glands (24%) of 37 patients undergoing transphenoidal hypophysectomy for diffuselly metastatic breast carcinoma. In all cases the preoperative neurological examination was negative, as were neuroradiological studies, including skull X-ray, tomograms of the sells turcicabrain scan, and angiography. Diabetes insipidus, however, was seen more frequently in patients with pituitary metastasis preoperatively (3 of 9) and postoperatively (8 of 9). Four of the nine patients with pituitary metastasis developed severe diabetes insipidus, which continued more than one month, while similar severe disease was seen in three of twenty-seven cases with no pathological evidence of pituitary metastasis. The prognosis in patients with pituitary metastasis was poor, with seven of the nine dying with an average survival of eighteen months. Pathological studies disclosed metastatic lesions in the anterior lobe (78%), posterior lobe (44%), and stalk (11%). The study emphasized that pituitary metastases, usually considered to be rare, occurred in 24% of patients with diffusely metastatic breast carcinoma. Such metastases correlate with the development of severe diabetes insipidus and with poor prognosis.

Adult↗
PubMed1977

On the origin and nature of the pituitary gland capsule.

Observations under the operating microscope confirming the presence of a pituitary capsule are reported. This capsule envelops the anterior lobe of the pituitary, the neurohypophysis, and the pituitary stalk. It merges along the stalk with the intracranial pia mater. The origin and nature of this capsule are discussed in light of the known facts of development of the pituitary gland and surrounding structures. It is concluded that the pituitary gland capsule is a derivative of the primitive pia mater.

Humans↗
PubMed1976

Hemangiomas of the internal auditory canal.

Three patients who presented with symptoms and signs of acoustic tumors are described: one of them had an arteriovenous malformation and the other two had cavernous hemangiomas. The common feature in all these patients was the presence of marked facial weakness with or without fasciculations and a complete loss of hearing in the presence of a small tumor. The cerebrospinal fluid protein was normal in these patients. Polytomography and Pantopaque cisternograms were used to make the diagnosis. Since these lesions are circumscribed, they are suitable for removal using microneurosurgical techniques.

Adult↗
PubMed1975

Neuroepithelial (colloid) cysts of the septum pellucidum.

The authors present two cases of neuroepithelial (colloid) cysts found above the diencephalic roof, occupying the space between the two fornices and the two leaves of the septum pellucidum, and describe the clinical history, neurological, and neuroradiological findings. Both lesions were removed through a right transventricular-transseptal approach. No other report of such a lesion in this location could be found in the review of literature. The pathogenesis of these cysts, both above and below the diencephalic roof, is discussed in light of the developmental anatomy of the area under consideration. In view of their origin from the neuroepithelium in the diencephalic roof, whether by a process of invagination into the third ventricle or by evagination into the velum interpositum, the so-called colloid cysts are more appropriately termed neuroepithelial cysts.

Adult↗
PubMedDate not supplied

Magnetic resonance imaging of cerebral aspergillosis.

Aspergillosis of the central nervous system is rare. It most commonly occurs in patients with long-standing immunosuppression. To our knowledge this is the first reported case describing the magnetic resonance imaging (MRI) findings in cerebral aspergillosis. The computed tomography (CT) scan findings are also included.

Adult↗
PubMedDate not supplied

Autopneumonectomy with compensatory lung growth.

A 23-year-old female immigrant from Ethiopia presented with a history of hemoptysis and an abnormal chest x-ray. A computed tomography scan showed that her left lung was greatly shrunken and her right lung was very large but structurally normal. She had a history of multiple respiratory infections as a young child but had been well since the age of five years. Her lung function was within normal limits except for an increased residual volume. It is very likely that her left lung was destroyed early in childhood and that her right lung underwent compensatory growth. She did not show airways obstruction, which is usually seen when compensatory lung growth occurs after surgical removal of lung tissue; this may indicate that, in those cases, the surgery compromised airway function.

Adult↗