Biomedical subjects

I Cobeta

Publications and source records attributed to I Cobeta.

21 records · Page 2Linked to original sources

PubMedDate not supplied

[Pathophysiological basis of aminoglycoside-induced ototoxicity].

Recently proposed etiopathological mechanisms of aminoglycoside-induced toxicity were reviewed, including calcium, phosphatidylinositol, Na-K dependent ATPase, and neuronal sites of antibiotic action. Difficulties in evaluating the true clinical incidence of this aminoglycoside-induced ototoxicity and risk factors were analyzed. The relation between new dosing regimens (single daily dose) and ototoxicity are discussed.

Aminoglycosides↗

PubMedDate not supplied

[Harmonic/noise ratio and spectrographic analysis in vocal abuse pathology].

Vocal abuse lesions disturb voice production by increasing the presence of noise in the voice. The harmonic-to-noise ratio (H/N) and spectrography are two different ways to evaluate noise components in the voice. A study was made of 52 patients (32 polyps, 11 Reinke's edema and 9 nodules) who underwent microlaryngeal phonosurgery. The grade of glottic closure was determined by stroboscopy; H/N and the long-term average spectrum (LTAS) at low-frequency (0-2000 Hz) were measured with a CSL-4300 instrument. Stroboscopy and acoustic analysis were made before surgery and two week and one month after surgery. Before surgery, the LTAS revealed weak harmonics, as shown by H/N values. After surgery, H/N values and harmonic energy increased. Preoperative and postoperative differences were significant (p < 0.05). Improved glottic closure after surgery improved the acoustic parameters.

Edema↗

PubMedDate not supplied

[Surgery of the laryngeal framework: type I thyroplasty].

Eight type I thyroplasties were performed. All the patients had a breathy voice related with unilateral vocal cord paralysis. Several causes were involved. All 8 patients achieved good glottic closure and the free edges of the vocal cords mi closed uniformly. Acoustic parameters were studied using Dr. Speech version 2.0 for Windows. The SPSS program was used for statistical analysis. The study showed significant improvement in maximum phonation time, shimmer, and normalized noise energy. Modifications in the surgical technique are discussed.

Adult↗