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Biomedical subjects

I D Kosachev

Publications and source records attributed to I D Kosachev.

At least 19 recordsLinked to original sources
PubMed1992

[Characteristics of chemotherapy of infectious diseases associated with gunshot wounds and trauma].

The experience in treating infectious diseases in wounded and traumatized persons from the contingent of the Soviet Troops in ++Afghanistan is described. The syndrome of the joint effect of the injury and infection is characterized. Features of the chemotherapy of the injured patients with viral hepatitis, malaria, typhoid fever and enteric and ++extra-enteric amebiasis under the ecological and professional stress and with an account of the etiology of the wound infection are presented. The favourable effect of the developed methods for chemotherapy of the joint affections was shown.

Afghanistan↗
PubMed1991

[The surgical aspects of the lessons of the war in Afghanistan].

There were no two identical wars in human history. From the medical point of view, the civil war, which is still going on in Afghanistan, also has its own face. The structure of sanitary losses, the character, gravity, and peculiarities of gunshot pathology give the possibility to call it as a mine war, because of its massive and, above all, effective mine warfare. The war in Afghanistan conclusively proves the predominance of blast injuries over other sanitary losses in the structure of combat surgical pathology, that may be considered as a common feature for the wars of century XX. The mine blast trauma must be regarded as a combat heavy concomitant trauma or gunshot blast polytrauma. This statement is the basic one for the rest of medical lessons gained from the war in Afghanistan. Using the comparative analysis of the different functions of medical service of two armies, the article shows the priority of organizational aspects for care and treatment of the wounded in war.

Afghanistan↗
PubMed1990

[Antibiotics in the treatment of wounds in the victims of the earthquake in the Armenian SSR].

Purulent wounds in 88 victims of the Armenian earthquake with the syndrome of long-term squeezing were examined microbiologically and the experience with using antimicrobial drugs for their treatment was analyzed. In all the cases microbial associations were detected, coliform and nonfermenting gram-negative bacilli, enterococci, anaerobes and yeast-like fungi being isolated from 80, 20, 15 and 25 per cent of the patients respectively. 130 bacterial strains were studied in detail. 80 to 100 per cent of the bacterial isolates were resistant to the antibiotics routinely used in surgical practice, i.e. benzylpenicillin, tetracycline, levomycetin, kanamycin, cephalothin and cefazolin and highly sensitive to new antimicrobial drugs belonging to ureidopenicillins (mezlocillin), quinolones (ciprofloxacin) and cephalosporins of the 3rd generation (cefoperazone and ceftazidime). Retrospective estimation of the antibiotic therapy revealed its inadequacy in 55.7 per cent of the patients for the most part because of the isolates resistance. The 19 variants of the antibiotic use prescribed by the physicians mainly included penicillins, aminoglycosides and their combinations (in 67.2 per cent of the cases). The use of the highly efficient drugs of the groups of ureidopenicillins and quinolones was extremely rare which was likely due to lacking of information on the drugs.

Anti-Bacterial Agents↗
PubMed1983

[Morphology of healing of an experimental gunshot wound following primary surgical treatment].

The time-course of healing of a perforating gunshot wound of soft tissues after primary surgical treatment was studied histologically, histochemically and electron microscopically in 24 rabbits. Throughout the observation period (1-28 days) disorders of the microcirculation, inflammatory reaction, degenerative and necrotic changes, disorders of the ultrastructure and metabolic processes in cells were observed in the wound tissues. Morphological changes developed in the zone of molecular concussion the presence of which delayed healing of the gunshot wound and reduced the efficiency of the primary surgical treatment. The experimental results extend current knowledge of the morpho-functional features of healing of gunshot wounds and indicate the proper choice of rational methods for surgical treatment.

Animals↗
PubMed1977

[Use of oxyglucocycline in surgical practice].

A new antibiotic -- oxyglycocycline was applied in 107 cases of different surgical diseases. In 52 patients the antibiotic concentration in the blood and tissues was studied, and it was shown that the therapeutic concentration of the drug remains in the blood and tissues for 12 hours. Good tolerance to the drug was proved. There were no unfavourable effects upon the organism related to the use of the antibiotic. Oxyglycocycline is recommended for broad use in surgical practice being a good therapeutic and prophylactic preparation in case of surgical infection.

Adolescent↗