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Biomedical subjects

I D Stewart

Publications and source records attributed to I D Stewart.

7 recordsLinked to original sources
PubMed2001

Nonsteroidal anti-inflammatory drug-induced strictures of the colon: report of a case and review of the literature.

The phenomenon of strictures of the colon induced by nonsteroidal anti-inflammatory drugs is a newly recognized pathologic entity that has gained little exposure in the surgical literature to date. A further case is reported and the clinical features of this entity are discussed. Most patients present with symptoms suggestive of malignancy, namely anemia, obstructive symptoms, or weight loss. Pathologic changes are characterized by diaphragm-like strictures with submucosal fibrosis. Surgical resection to exclude malignancy and treat symptoms along with cessation of the nonsteroidal anti-inflammatory drug is the treatment of choice.

Anemia↗
PubMed1991

Pancreatobiliary diversion enhances experimental pancreatic carcinogenesis.

Since compensatory hyperplasia promotes experimental carcinogenesis in the gut, we tested the ability of two surgical models of pancreatic growth to promote pancreatic carcinogenesis. Male Wistar rats (n = 60) weighing 250-300 g underwent pancreatobiliary diversion (PBD), 90% small bowel resection (PSBR) or triple transection and reanastomosis of the small intestine (controls). Postoperatively, each group received azaserine (20 mg kg-1 wk-1 i.p.) for 6 weeks. Surviving rats were killed at 6 months, pancreatic wet weight was measured and histological sections were examined for atypical acinar cell foci (AACF), the putative precursor of carcinoma. Median relative pancreatic weight (mg pancreas/g body weight) was 2.20 for controls (n = 18), 4.08 for PSBR (n = 11) (P less than 0.001) and 6.86 for PBD (n = 16) (P less than 0.001). PSBR did not affect the development of acidophilic AACF, but PBD produced an enormous increase in their number per cm3 (median 96 vs. 0; P less than 0.001) and a 7-fold increase in their volume (P less than 0.001). Both operations cause pancreatic growth, but only PBD promotes carcinogenesis, possibly because of its unique hormonal effect.

Animals↗
PubMed1986

Urinary tract lymphoma.

Urinary tract involvement by non-Hodgkin's lymphoma is uncommon and whilst extranodal disease may be the first manifestation of NHL in 15% of patients, the primary site of origin of NHL in the urinary tract is very rare. At the time of diagnosis, apparently primary urogenital lymphoma is often widely disseminated, with a correspondingly poor prognosis.

Adult↗
PubMed1981

Rugby injury survey 1979.

In a prospective study 1085 rugby players and their injuries were recorded in the 1979 playing season. The age, grade, position, fitness and ground conditions did not affect the injury pattern. The majority of injuries were insignificant requiring no hospital follow up. The tackle accounted for 44 percent of all injuries. Set play does not contribute significantly to the number of injuries. The head and neck was the most frequently involved site, followed by the lower limbs. Foul play was implicated in 15 percent of all injuries. More stringent refereeing and coaching of the tackle could aid in reducing the number and severity of rugby injuries.

Age Factors↗