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Biomedical subjects

I D Wolfe

Publications and source records attributed to I D Wolfe.

4 recordsLinked to original sources
PubMed1985

Multicentric reticulohistiocytosis and Sjögren's syndrome.

A 66-year-old man with an 18-year history of cutaneous multicentric reticulohistiocytosis (MRH) developed a chronic destructive symmetrical arthritis and xerostomia. Biopsies of synovium and minor salivary glands established a diagnosis of MRH polyarthritis and lymphocytic infiltrative Sjögren's syndrome, respectively. Anti-Ro(SSA) antibody was present. Hypothyroidism was also identified. This report of Sjögren's syndrome in MRH may enlarge the spectrum of autoimmune diseases associated with MRH.

Aged↗
PubMed1978

Epithelioma cuniculatum.

The cases of epithelioma cuniculatum in this report illustrate the unusual appearance and diagnostic difficulty of the lesion. Early diagnosis resulted in apparent cure with adequate local excision in some cases, whereas amputation was necessary for advanced or recurrent tumors. Distant metastasis may occur. Superficial biopsy specimens may yield inadequate tissue for proper diagnosis. Verrucous carcinoma should be considered as a diagnostic possibility in any atypical or recurrent "wart" on the sole.

Carcinoma, Squamous Cell↗
PubMed1976

Cutaneous protothecosis in a patient receiving immunosuppressive therapy.

A 30-year-old recipient of a renal transplant, who was receiving immunosuppressive therapy, developed cutaneous abscesses from which an organism of the genus Prototheca was cultured. The patient died of Klebsiella septicemia. At the time of death, pure cultures of Prototheca and Candida organisms were grown from separate skin lesions. Prototheca is a genus of achloric algae. Cultural, microscopical, and staining characteristics separate these organisms from the yeast and fungi. Cutaneous protothecosis was first described in 1964 by Davies et al in an otherwise healthy African rice farmer. Since that time, nine other cases have been reported. However, only a single case has been described in a patient receiving immunosuppressive drugs, a woman with carcinoma of the breast who was receiving chemotherapy with multiple agents.

Abscess↗