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I D Wootton

Publications and source records attributed to I D Wootton.

17 recordsLinked to original sources
PubMed1977

Data processing in pathology laboratories: the Phoenix system. 3. Further programs, staff training, and system performance.

This paper completes the description of the Phoenix system by outlining the additional programs necessary to maintain the data files in a satisfactory condition and prevent them from becoming overfilled. The standards of training required by the operating staff are discussed an assessment is made of the system performance in terms of cost/benefit. This was achieved by observing the time spent by staff during a period when the throughput of work was accurately measured. From these figures it is possible to estimate the needs of another laboratory. Finally, the continued extension of the computer facilities into other pathology disciplines and the provision of terminals in the hospital is described.

Chemistry, Clinical↗
PubMed1976

Intravenous fat-tolerance test in ischaemic heart disease and peripheral vascular disease.

1. The intravenous fat-tolerance test and serum lipid and lipoprotein measurements were carried out in ninety-three normal subjects, fifty-one patients with ischaemic heart disease and thirty patients with peripheral vascular disease. 2. The fractional turnover rate of exogenous triglyceride was significantly slower in patients with ischaemic heart disease and in patients with peripheral vascular disease than in normal men. The rate was also slower in normal men than normal women. 3. Serum triglyceride and cholesterol concentrations were higher in both vascular disease groups than in control subjects. 4. The proportion of both groups of patients who had a subnormal fractional turnover rate of exogenous triglyceride was 35%, and 32% of patients had hypertriglyceridaemia in the fasting state; 27% of patients were hypercholesterolaemic. 5. Although the intravenous fat-tolerance test did not provide significantly better discrimination between cardiovascular patients and control subjects than did measurement of serum triglyceride, the results suggest that hypertriglyceridaemia in such patients may be separable into a group in which impaired triglyceride clearance may be partly responsible, and a group in which overproduction of serum triglyceride may be the major mechanism of the hyperlipidaemia.

Adult↗
PubMed1974

Serum lipoprotein abnormalities in patients with ischaemic heart disease: comparisons with a control population.

The frequency and nature of abnormalities of serum lipoproteins have been studied, using quantitative techniques, in 143 patients with ischaemic heart disease (I.H.D.). Rigorous selection criteria were used. The findings were related to the distribution of lipoprotein concentrations in a carefully screened control population. Hyperlipoproteinaemia occurred in 55% of patients and in 11 out of 15 patients aged less than 40 years. Raised triglyceride and cholesterol concentrations in very low density lipoprotein were the most frequent abnormalities followed by raised cholesterol content of low density lipoprotein. In young patients high density lipoprotein levels were subnormal. Hyperlipoproteinaemia of W.H.O. types IIa, IIb, III, IV, and V all seemed to be over-represented in I.H.D. I.H.D. patients with type IIa, IIb, and IV abnormalities were all significantly younger than I.H.D. patients with normal lipoprotein levels.

Adult↗