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Biomedical subjects

I Dehnert

Publications and source records attributed to I Dehnert.

10 recordsLinked to original sources
PubMed1986

[Results of hyposensitization with bee and wasp venom].

The immunotherapy with purified bee and wasp venom is indicated for patients with severe general reactions after insect stings, positive prick test and positive RAST. One hundred seventy four persons were treated for three years with bee venom (SSW Dresden) and 34 patients with wasp venom (Reless). Challenge by a stinging bee after treatment proved in 90 per cent complete protection. There were no general reactions during hyposensitization with wasp venom, but in 46 per cent occurred general reactions during immunotherapy with bee venom. Therefore rush desensitization should be performed in indoor patients till a top dose of 100 micrograms/ml is reached. Booster injections can be given to outdoor patients. All individuals with systemic reactions after insect stings have to get an emergency treatment kit and must be familiar with its application.

Bee Venoms↗
PubMed1984

[Morphologic findings on the formal genesis of pulmonary alveolar proteinosis].

Cytological, cytochemical and immunopathological investigations were carried out at lung washings in a case of pulmonary alveolar proteinosis. There was an increased activity of alveolar epithelial cells of type II (AEZ II) with increased production of surfactant lipids. Abundant lipids of the surfactant system are also visible in the extracellular material rich in protein and lipids. Alveolar macrophages showed increased enzymatic activity with high levels of acid phosphatase and nonspecific esterase, but no phagocytosis of surfactant lipids. Immunopathological investigations exhibit a high content of IgG, IgM and IgA in the exudate. These findings demonstrate, that exudation of blood serum in alveoli and overproduction of surfactant material are two important processes in the formal genesis of alveolar proteinosis, dependent on each other.

Acid Phosphatase↗
PubMed1984

[Detection of the incidence of increased sensitization to molds in patients with bronchial asthma and allergic rhinitis].

The incidence of sensibilization against extracts of moulds produced by VEB SSW Dresden was investigated by intracutaneous tests in 354 persons (controls and patients - adults and children - with bronchial asthma and allergic rhinitis). Even in the nonallergic controls the tests were positive in 20-30%. Patients with asthma and rhinitis were significantly more often positive than controls with Mucor, Cladosporium and mixed-mould. There was no difference between the groups with Aspergillus and Penicillium. Testing with extract of mixed-mould is not effective. Positive results with the individual moulds were not excluded although the test with mixed-mould was negative. There was no essential difference in the incidence of sensibilization between adults and children with bronchial asthma using mould extracts of VEB SSW Dresden.

Adolescent↗
PubMed1984

[Implementation and evaluation of the inhalation antigen test in the diagnosis of exogenous allergic alveolitis].

By the aid of antigen inhalation challenge test 16 patients with precipitating antibodies to bird antigens (pigeons, hens, budgerigars) and the supposed diagnosis of extrinsic allergic alveolitis (EAA) were examined. Criterions for the evaluation of the objective parameters (FEV1, FVC, Ros, body-temperature, number of leukocytes) were established. The combination of objective parameters and subjective symptoms leads to the evaluation of the challenge test. Different types of bronchial response (monophasic and dual-responses) were observed after inhalation of antigens. In 7 cases the diagnosis of EAA was proved to be true according to the challenge test results. If there are no typical alterations in chest-x-rays and no alterations of ventilatory function, the antigen inhalation challenge test is the method of choice in the diagnosis of EAA.

Adolescent↗
PubMed1980

[Suggestions for diagnosis and differential diagnosis of bronchial asthma (author's transl)].

The diagnosis of bronchial asthma is difficult because dyspnea as the leading symptom is ambiguous. Often other diseases with dyspnea are called asthma. For long term treatment it is necessary to know the pathogenesis of asthma and the factors triggering attacks. This in many cases needs special investigations. In the present paper some proposals are given to make a preliminary diagnosis on the basis of history and simple clinical findings, giving the indication for consecutive investigations respectively referring the patient to a specialist.

Allergens↗
PubMed1979

[Morphological investigations of bronchial biopsy material in chronic bronchitis and asthma bronchiale (author's transl)].

Morphological investigations (light microscopy, enzyme histochemistry, immunopathology) were carried out in cases with asthma bronchiale and chronic bronchitis. According to the histological picture no additional parameters were found with enzyme histochemical and immunopathological methods to specify the diagnosis asthma bronchiale and chronic bronchitis. The most important diagnostic factors in chronic bronchitis are hyperplasy of mucous bronchial glands and atrophy of serous bronchial glands with a loss of activity of acid phosphatase. Diffuse thickenings of basal membrane were more often in asthma bronchiale, localized thickenings more often in chronic bronchitis. Hypertrophy of goblet cells, infiltrations with round cells and metaplasia are found both in asthma bronchiale and chronic bronchitis in different degree. Correlations exist between the activity of leucine aminopeptidase in the stroma of the bronchus and degree of cellular infiltration with lymphocytes and plasma cells.

Asthma↗