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Biomedical subjects

I Derakhshan

Publications and source records attributed to I Derakhshan.

At least 19 recordsLinked to original sources

Handedness and macular vision: laterality of motor control underpins both.

This article pursues the corollaries of the anatomy of handedness recently discovered. Specifically, it addresses the issues concerning central vision as it relates to the command center and the circuitry of the saccades. It presents data that support the directionality of callosal traffic in motor and sensory realms even further. Evidence is presented that denotes a relationship between the anatomy sustaining movement control and that responsible for the part of the vision handled by the maculae. The evidence shows bypassing of the callosum by fibers serving the central vision. This aspect has ramifications for surgical approach to the third ventricle by callosotomy, relaxing the earlier prohibitions advocated in approaching the third ventricle via splenectomy.

Brain Mapping↗

Callosum and movement control: case reports.

This article explores the role of directionality of callosal traffic (codified as handedness), based on personal clinical observations and a critical review of the literature. Based on this evidence, a technical definition of handedness is offered as opposed to the behavioral method in use until now. In the vast majority of right-handers neural and behavioral handedness match. The situation is the opposite in left-handers where two thirds of them are wired to be right-handers, causing the well-known heterogeneity seen in left-handed cohorts. The callosum-length proximity of the dominant side of the body to the command center in the major hemisphere is the source of its neurophysiological superiority compared to the nondominant side. Clinical syndromes in which the new scheme are manifested are reviewed, indicating the existence of an excitatory influence by the neuronal aggregate devoted to voluntary actions, housed in the major hemisphere, on their counterparts in the minor hemisphere. The latter is exclusively devoted to volitional movements occurring on the nondominant side. Thus, it is the directionality of callosal traffic that is responsible for cerebral asymmetries seen in the motor realm.

Adult↗

Subacute sclerosing panencephalitis: clinical and immunologic study of 23 patients.

Lymphocyte subpopulations ("active' T cells, total T cells, and B cells), leukocyte migration, lymphocyte transformation, complements (CH50, C3, and C4), and immune complexes in serum and cerebrospinal fluid were studied in 23 patients with subacute sclerosing panencephalitis. The percentage of active T cells was normal. The number of patients with positive migration inhibitory response to phytoyhemagglutinin was lower than controls, corresponding to the diminished percentage of total T cells in patients. C1q binding (immune complex formation) was found in the sera of 10 patients.

Adolescent↗

Holoprosencephaly. Computerized tomographic and pneumographic findings with anatomic correlation.

This report describes the computerized tomographic, pneumoencephalographic, and anatomic findings in a case of holoprosencephaly. Computerized tomography is suggested as the most accurate diagnostic method in defining the nature and extent of those anomalies related to the failure of cleavage of the prosencephalon. The value of this method in detecting less severely affected family members is evident.

Agenesis of Corpus Callosum↗