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Biomedical subjects

I Dikov

Publications and source records attributed to I Dikov.

18 recordsLinked to original sources
PubMed2003

[Prevention of neural tube defects with folic acid].

Neural Tube Defects (NTD's) include a large number of congenital malformations produced when the open neural tube presents a very early stages in the development of the human embryo fails to close on or before the first month post conception. NTD's are considered to be one of the most common forms of malformations with varying degrees depending of genetic and environmental conditions. The studies prove that the additional taken of folic acid plays an important role against the NTD's. Numerous studies prove this "B" vitamin has an important protective effect not only for the recurrence of NTD's, but for new cases too. In light of these, in 1992 the US Public Health Services issued the recommendation that all women in child-bearing age should consume at least 0.4 mg (400 micrograms) of folic acid daily.

Female↗
PubMed2001

[Prophylaxis with tercef of infection-related complications after cesarean section].

The purpose of this prospective and case controlled study is to determine the effectiveness and safety of antibiotic prophylaxis with Tercef (ceftriaxone) in women undergoing cesarean section and to compare the results with those of 24 hours regiment of Cefazolin and also with a group without prophylaxis. The study includes 122 cases of elective and emergency CS: 41 with a single intravenous dose of 1.0 g Tercef after clamping of the umbilical cord; 41 cases of antibiotic prophylaxis with Cefazolin three times 2.0 g for 24 hours and 40 low infectious risk CS without antibiotic prophylaxis. We take in account the existing before the CS risk factors for postoperative infectious complications as: hours of PROM; length of labor, number of vaginal examinations before CS, previous sections, duration of the operation, anemia, bacteriuria and diabetes. For post CS infection-related complications we take: febrile morbidity, endometritis, wound infections, infection of urinary tract. The results show infection complication in the three groups as follow: 14.6% for tercef, 17.1% for cefazolin and 20.0% for the group without antibiotic. There is not statistically significant difference. According our study in cases of CS with increased risk of post-operative infectious complications the antibiotic prophylaxis reduce the rate of infection-related complications even below that of CS with low infectious risk. The single dose of 1 g tercef i.v. is effective and suitable in comparison with 24 hours regiment of cefazolin.

Antibiotic Prophylaxis↗
PubMed1996

[Hemorheological parameters in the prognosis of the risk of fetal retardation in pregnancy with arterial hypertension].

The haemorheological theory creates the notions of the interrelationship between the haemodynamic alterations in the blood flow and the whole-blood viscosity. The whole-blood viscosity is a variable parameter in close relation to the vessel geometry and blood flow rate, the blood plasma viscosity, the volume concentration of the blood cells, mostly of the red blood cells (the haematocrit) as well as to the hydrodynamically effective haemorheological phenomena of the aggregation and deformability of the erythrocytes. In the onward development of pregnancy in Bulgarian women with pre-eclamptic signs an increase of the haematocrit, the haemoglobin concentration and the erythrocyte aggregation were found. These data could be of benefit as reference point of possible risk-conditions for the mother during the pregnancy advance and in the same time of manifestation a retardation and/or stillbirth or neonatal death.

Erythrocyte Aggregation↗
PubMed1995

[The incidence of clinical forms of female endocrine sterility in 1990-1993 at the III Gynecological Clinic of the Maternity Home of the State Institutional Hospital].

The high frequency of the female endocrine sterility and the favorable therapy results are showing categorically the importance of the endocrine sterility as a medical and a social problem. For the period 1990-1993 in Third Gynaecological clinic--Sector of Gynaecological Endocrinology, were observed 584 patients with proved endocrine sterility. The present research has the goal to discuss the frequency of the different clinical forms of the endocrine sterility. The most frequent one is PCO--30.59%, followed by corpus luteum insufficiency--23.58%, and hyperprolactinaemia--20.05%. The results are interpreted on the basis of similar research for the period 1976-1985 with analog contingent. Conclusions are made for the essential directions of the diagnostic and therapy process in the clinic.

Bulgaria↗
PubMed1995

[The medicosocial aspects of contraception for teenagers].

The authors study and examine the influence of some medical and social factors on the teenagers use of contraceptives. The study is based on the questionnaires fulfill by 568 teenagers (aged 13-19). In the enquêtes are shown the role of the family status of the parents the involvement of the family and the school in the sex education, and also are indicated the favorite teenager's contraceptive methods. The positive attitude on contraception and on this kind of researches is very characteristic for 94% of the analyzed teenagers. The authors made a conclusion on optimizing the use of modern contraceptives for teenagers.

Adolescent↗
PubMed1990

[The use of the triphasic contraceptive preparation trisiston for therapeutic purposes].

After a brief review of the qualities of the new triphasic contraceptive preparation Trisistone and some of its advantages in comparison with the other combined contraceptive drugs the authors report on the results from the first study, carried out in our country, on the therapeutic effect of Trisistone. Thirty-eight women with various gynecological diseases were treated. The largest group was that of women with irregular bleedings. In this group the effect was not good in all women. It was found that Trisistone had limited possibilities to control irregular uterine bleedings, which most probably was connected with its comparatively low dose of steroid hormones. The side effects were comparatively slight and not quite frequently. The most frequent side effect was the occurrence of irregular bleeding in 9.5% of the treated women. The state without any side effects was improved in 30.1% of the patients. Best results were found in women with postcastration syndrome, hypoestrogenism and congenital anomalies in the development of ovaries--primary ovarian dysgenesis. Trisistone is especially suitable for substituted treatment in women with ovarian hormonal deficit.

Adult↗
PubMed1989

[Diagnostic and therapeutic problems in typhoid fever complicated by severe enterorrhagia (apropos a patient successfully treated by surgery)].

The case history of a 69-year-old patient with typhoid fever is described. The disease ran an atypical course; with early jaundice syndrome, severe enterorrhagia and late appearance of roseola. He was successfully treated by surgical intervention--hemicolectomy. The need of surgical treatment of patients with typhoid fever, who have severe, life-threatening enterorrhagia, is emphasized.

Acute Disease↗
PubMed1989

[Our experience in using the triphasic contraceptive trisiston for contraception].

The authors carried out studies on 80 women, using Trisistone, a preparation of Germed, Jenapharm, DDR, in the course of 250 cycles, taking into consideration the advantages of triphasic contraceptive preparations as well as the fact that till this moment there were not applied in our country. A good contraceptive efficiency was established. No case with conception was recorded. The side effects were mild and and their frequency varies between 2.4 and 9.7% Irregular bleedings were the only disadvantage of Trisistone, which caused refusal for its usage. It is proposed that Trisistone should be used as an initial contraceptive preparation like the preparations with "mini" doses. In cases with good tolerance women should continue to use it, but they should take another contraceptive preparation, when bleeding occurs.

Contraceptive Agents↗