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Biomedical subjects

I Dimopoulos

Publications and source records attributed to I Dimopoulos.

7 recordsLinked to original sources
PubMed2003

Can high resolution computed tomography predict lung function in patients with chronic obstructive pulmonary disease?

High-resolution computed tomography (HRCT) is a useful method for quantifying the extent of emphysema. Few reports have mentioned the relationships between HRCT scans and pulmonary function tests in chronic obstructive pulmonary disease (COPD). For diagnosis, COPD requires chronic airflow limitation and emphysema and/or chronic bronchitis. We examined 20 who were previous smokers with middle to moderate COPD. All were normocapnic with mean arterial oxygen pressure (PaO2) 77,52 +/- 16,789 mmHg. Forced spirometry, somatic plethysmography and cardiopulmonary exercise test were performed in each patient. HRCT was performed in both full inspiration and full expiration at three levels through the upper (at the aortic arch), lower (2 cm above the diaphragm), and middle lung (midpoint between upper and lower) levels. During expiration all pulmonary function parameters correlated with the HRCT grade in the middle right and left part of the lungs. The middle right part of the lung during expiration correlated statistically significant with MVV (r = -0.681, p = 0.001), forced vital capacity (FVC) (r = -0.477, p = 0.027), forced expiratory volumein 1 sec (FEV1) (r = -0.632, p = 0.002), resistance (r = 0.674, p = 0.001), residual volume (RV) (r = 0.733, p = 0.001), total lung capacity (TLC) (r = 0.696, p = 0.001), functional residual capacity (FRC) (r = 0.752, p = 0.001) and peak oxygen consumption during exercise (VO2) (r = -0.493, p = 0.023). The middle left part of the lung during expiration correlated statistically significant with MVV (r = -0.673, p = 0.001), FVC (r = -0.493, p = 0.027), FEV1 (r = -0.629, p = 0.003), resistance (r = 0.593,p = 0.005), RV (r = 0.601, p = 0.005), TLC (r = 0.546, p = 0.012), FRC (r = 0.594, p = 0.006) and peak VO2 (r = -0.525, p = 0.015). Forced expiratory volume in 1 sec (FEV1), which is a well-established measure of airflow obstruction, correlated with the HRCT grade (1) in the middle left part of the lung during inspiration (r = -0.468, p = 0.035) and during expiration (r = - 0.629, p = 0.003) (2) in the lower right lung during inspiration (r = -0.567, p = 0.007) and during expiration (r = -0.558, p = 0.008) (3) in the lower left lung during inspiration (r = -0.542, p = 0.011) and during expiration (r = -0.558, p = 0.008) (4) in the upper right lung during expiration (r = -0.469, p = 0.037) (5) in the upper left lung during expiration (r = -0.463, p = 0.035) and (6) in the middle right lung during expiration (r = -0.632, p = 0.002). According to our results HRCT was a valuable tool for evaluating the severity of COPD--especially the middle right and left part of the lungs, during expiration--and correlated well with pulmonary function tests.

Exercise Test↗
PubMed2003

Asymptomatic adult cystic lymphangioma of the spleen: case report and review of the literature.

In the present report we describe a case of an asymptomatic splenic cystic lymphangioma in a 43 year-old female. Only a few cases of this benign tumor have been reported in adult patients so far. Clinical examination revealed a tender mass in the upper left quadrant of the abdomen. Abdominal ultrasound and CT-scan revealed a large well-defined splenic cystic mass surrounded by multiple peripheral cysts, all divided by thin septa. MRI confirmed these findings and excluded the possibility of malignant degeneration. Histologic examination permitted the accurate diagnosis to be made. Different imaging findings of this tumor have been described but only a few reports have focused on the value of MRI imaging.

Adult↗
PubMed1990

[The use of homologous coagulated blood for prevention of pneumothorax following percutaneous lung biopsy (experimental study)].

We performed 52 percutaneous lung biopsies on 34 animals (NZ rabbits) using a coaxial needle system. In 19 animals we introduced homologous clotted blood through the outer plastic cannula in order to prevent a pneumothorax. CT was used to demonstrate the pneumothorax. The aim of the experiment was to see whether clotted blood would reduce the incidence of pneumothoraces. In addition we wanted to determine the complications of this method. We found that, correctly used, clotted blood significantly reduced the incidence of pneumothoraces (31.57% as against 64.70% in the control group). It also reduced the extent of the pneumothorax. The method has no complications.

Animals↗
PubMed1989

Is natural infection with M. tuberculosis protective against cancer?

In order to investigate the effect of natural infection with M. tuberculosis on cancer incidence, a case-control study was undertaken on 108 recently diagnosed cancer cases (all sites) and 317 controls. After removal of cancer cases or controls considered immunoincompetent (25% and 17% respectively), the remaining subjects were tested by intradermal injection of tuberculin (5 I.U.). Results were compared separately for each sex. It was observed that the proportion of tuberculin-negative subjects was higher in cancer patients than in controls within each sex (males 31.3% vs 20.1%, females: 59.2% vs 37.3%) the difference in females being statistically significant (p less than 0.02). Odds ratio for negative tuberculin test was 1.80 and 2.44 for males and females respectively. The results are discussed on the basis of cell-mediated immunity produced by infection with M. tuberculosis and its relations with tumor growth.

Cohort Studies↗
PubMed1989

[MRT of the status following augmentation plasty of the anterior cruciate ligament using carbon fibers].

In 19 patients treated with carbon-fiber ligament augmentation for the anterior cruciate ligament, the clinical findings were compared via MRI. Visualization of the intra- and extra-articular portion of the graft was possible in 84%. The integrity of the ligaments was be shown in an equal percentage. Thus, MRI is a useful diagnostic tool for non-invasive imaging for repeated follow-ups in patients with carbon-fiber ligament augmentation.

Adolescent↗
PubMedDate not supplied

Fibrin glue for sealing the needle track in fine-needle percutaneous lung biopsy using a coaxial system: Part II--Clinical study.

PURPOSE: Following percutaneous lung biopsy (PLB), we used fibrin glue as a sealant in 26 patients for the purpose of decreasing the incidence of pneumothorax. METHODS: All 26 patients (group A) had chronic obstructive pulmonary disease (COPD). The results for group A were compared with a control group of 32 patients (group B), also with COPD and in whom fibrin glue was not used. All biopsies were conducted under computed tomography (CT) using a coaxial needle system consisting of 19-gauge and 22-gauge needles. RESULTS: Pneumothorax developed in five patients (19.2%) in group A and in one instance, drainage was required (3.8%). In group B, pneumothorax developed in 13 patients (40.6%) and in six instances (18.8%) drainage was required. Comparing the use of chest-tube drainage in the two groups, a statistical significance was observed, p < 0.0025). No adverse reactions related to the fibrin glue were observed. CONCLUSION: Our results indicate that fibrin glue is a safe sealing material for lung PLB and serves to decrease the incidence and, in particular, the severity of pneumothorax, especially in high-risk patients.

Aged↗